Influence of temperature on the compaction of an organic powder and the mechanical strength of tablets

Abstract

The purpose of this work consists in following the dependence of physical properties on the temperature during the compaction of an organic component. A special thermo-regulated die has been developed to realize uniaxial compression at different constant temperatures. This study has shown that a temperature change modifies the microstructures and the mechanical behaviour of the tablets. The measurement of the tablet porosity during the compression cycle allows us to conclude that temperature influences mainly the phenomena occurring during the isobaric stage of the compression cycle and not the ones during the pressure increase. On the other hand, during the pressure increase, the acoustical activity of the powder is reduced when temperature increases. The tensile strength of tablets realized at different temperatures was also studied and shows a maximum around 60 °C that can be explained by the SEM analysis of the microstructure of the tablets.

Temperature Evolution during Compaction of Pharmaceutical Powders

“…Despite its potential significance, however, it has attracted only limited attention, particularly in view of its potential effects on tablet properties. Among other possible effects, the temperature of a tablet during compaction may affect compressibility and strength,2 the performance of lubricants, die wall friction, and ejection force3 as well as physicochemical changes in drug substance, for example, chemical stability and crystallinity or polymorphic state 4. Early results showed a clear dependency of the postejection temperatures of tablets on compaction rate (e.g.,5, 6), which indicates that the level of temperature in compaction may also be important for process scale‐up.…”

Critical Review on Engineering Mechanical Quality of Green Compacts using Powder Properties

“…Compact's mechanical strength is influenced by many parameters including temperature (Rouèche et al, 2006) or properties of particle including particle size (Narayan and Hancock, 2005) in case of tensile strength. Finer particles tend to result in stronger compacts owing to higher surface area (Alderborn and Nystrom, 1996).…”

A Review of the Advancements in Probiotic Delivery: Conventional vs. Non-conventional Formulations for Intestinal Flora Supplementation

“…Furthermore, with tablets and capsules being easier to administer to patients and due to their increased storage stability over liquid preparations, capsules and tablets are currently the preferred dosage forms for the delivery of probiotics to the human body (65). The concern with tablets, however, is the heat production that occurs during compression with temperatures reaching up to 60°C, which can destroy bacteria that are most viable at their optimal temperatures (52,66). Other conventional delivery systems for probiotics include microcapsules and beads, which have been shown to drastically increase the number of viable bacteria surviving the formulation process, storage period, and subsequent delivery to the intestinal system (32,47).…”