Temperature Evolution during Compaction of Pharmaceutical Powders

Zavaliangos, Antonios; Galen, Steve; Cunningham, J. C.; Winstead, Denita

doi:10.1002/jps.21229

Cited by 54 publications

(43 citation statements)

References 30 publications

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“…A coupled mechanical and thermal analysis of powder compaction was performed using the finite element method (FEM) by Zavaliangos, Galen, Cunningham & Winstead (2007), who examined the evolution of the temperature distribution when a microcrystalline cellulose (MCC) powder (grade Avicel PH102) was compressed with flatfaced punches to make flat-faced tablets. The temperature variation on the surface of the tablet was also experimentally measured using an infrared thermoviewer, in order to validate the numerical analysis.…”

Section: Michrafy Et Al (2005)mentioning

confidence: 99%

Finite element analysis of thermomechanical behaviour of powders during tabletting

Krok

García‐Triñanes

Peciar

et al. 2016

Chemical Engineering Research and Design

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Section: Michrafy Et Al (2005)mentioning

confidence: 99%

Finite element analysis of thermomechanical behaviour of powders during tabletting

Krok

García‐Triñanes

Peciar

et al. 2016

Chemical Engineering Research and Design

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“…Decreased particle size increases the surface to volume ratio of the plant material 13–20 fold, which could enhance biochemical surface reactions in the material. When tablets are formed in a compression die, heat is generated, albeit for only a fraction of a second; this aids particle adherence and increases with the force of compaction (Bechard and Down, 1992; Zavaliangos et al, 2008). Compaction force of 20 kN can raise tablet surface temperature 5–30°C (Bechard and Down, 1992) with even greater increases during actual production as heat accumulates in the machinery during a long production run.…”

Section: 0 Results and Discussionmentioning

confidence: 99%

Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use

Weathers

Towler

2014

Industrial Crops and Products

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Artemisia annua L., long used as a tea infusion in traditional Chinese medicine, produces artemisinin. Although artemisinin is currently used as artemisinin-based combination therapy (ACT) against malaria, oral consumption of dried leaves from the plant showed efficacy and will be less costly than ACT. Many compounds in the plant have some antimalarial activity. Unknown, however, is how these plant components change as leaves are processed into tablets for oral consumption. Here we compared extracts from fresh and dried leaf biomass with compressed leaf tablets of A. annua. Using GC-MS, nineteen endogenous compounds, including artemisinin and several of its pathway metabolites, nine flavonoids, three monoterpenes, a coumarin, and two phenolic acids, were identified and quantified from solvent extracts to determine how levels of these compounds changed during processing. Results showed that compared to dried leaves, artemisinin, arteannuin B, artemisinic acid, chlorogenic acid, scopoletin, chrysoplenetin, and quercetin increased or remained stable with powdering and compression into tablets. Dihydroartemisinic acid, monoterpenes, and chrysoplenol-D decreased with tablet formation. Five target compounds were not detectable in any of the extracts of this cultivar. In contrast to the individually measured aglycone flavonoids, using the AlCl3 method, total flavonoids increased nearly fivefold during the tablet formation. To our knowledge this is the first study documenting changes that occurred in processing dried leaves of A. annua into tablets. These results will improve our understanding of the potential use of not only this medicinal herb, but also others to afford better quality control of intact plant material for therapeutic use.

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“…18 This could represent an important mechanism for energy dissipation and the mechanical heating that has been observed during compaction. [28][29][30][31][32] This phenomenon is widely known in the pharmaceutical industry, although it has received relatively little research attention. Moreover, since it could affect many aspects of the tabletting process, including compaction behaviour, strength, lubrication, friction, ejection forces and the crystal form or chemical stability of the drug, this merits further investigation.…”

Section: Discussionmentioning

confidence: 99%

Variations in Compaction Behaviour for Tablets of Different Size and Shape, Revealed by Small-Angle X-Ray Scattering

Laity

Han

Elliott

et al. 2010

Journal of Pharmaceutical Sciences

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Temperature Evolution during Compaction of Pharmaceutical Powders

Cited by 54 publications

References 30 publications

Finite element analysis of thermomechanical behaviour of powders during tabletting

Finite element analysis of thermomechanical behaviour of powders during tabletting

Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use

Variations in Compaction Behaviour for Tablets of Different Size and Shape, Revealed by Small-Angle X-Ray Scattering

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