Influence of solvents and gas chromatographic injector conditions on the detectability of nitroaromatic compounds

Emmrich, Monika; Lahrz, T.; Spyra, Wolfgang

doi:10.1016/s0021-9673(01)00758-0

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…In earlier studies, the glass wool material has been reported to decrease the detectability of, e.g. theophylline [31] and nitroaromatic compounds [32] as the glass wool either adsorbs or decomposes the analytes. In the present study, the use of empty inlet liners substantially increased the sensitivity of the method.…”

Section: Optimization Of the Methodsmentioning

confidence: 99%

Development and validation of a gas chromatographic–mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration

Turunen

Lehtonen

Järvinen

et al. 2008

Journal of Chromatography B

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Section: Optimization Of the Methodsmentioning

confidence: 99%

Development and validation of a gas chromatographic–mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration

Turunen

Lehtonen

Järvinen

et al. 2008

Journal of Chromatography B

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“…Sensitive detection methods are therefore required. GC and LCcombined with several detection methodshave been used most often, − but MEKC separations with bile salts in the separation buffer have also been reported. , Nitromonoaromatic compounds are also known for their toxicity; they are targeted in environmental analysis and for explosives detection using GC, , LC, and MEKC. , …”

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confidence: 99%

Quenched Phosphorescence Detection in Cyclodextrin-Based Electrokinetic Chromatography

et al. 2002

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Quenched phosphorescence detection is a sensitive detection method recently introduced in capillary zone electrophoresis. It is based on the dynamic quenching interaction of the analytes (quenchers) with a phosphorophore, 1-bromo-4-naphthalenesulfonate (BrNS), present in the separation buffer. In this study, it is shown that this detection method can also be used in cyclodextrin-based electrokinetic chromatography (CD-EKC) despite the presence in the buffer solution of cyclodextrins, which are known to reduce the luminescence quenching rate constants. Experiments indicate that BrNS mainly resides in the aqueous phase, while the analytes are distributed between both phases. In principle, the observed quenching might arise from the interaction of BrNS with uncomplexed as well as complexed analytes. However, from the dependence of the fractional quenching on the capacity factor (the normalized fractional quenching was found to be equal to the fraction of analyte in the aqueous phase), it was concluded that only aqueous-phase quenching contributes significantly to the observed quenching. Nevertheless, separation and detection can be regarded as fully compatible, because the capacity factors encountered in CD-EKC are generally low (in this study they ranged from about 0.1 to 2.5). Indeed, with nitroaromatic compounds as the target analytes, limits of detection in the 10(-8) M range were achieved.

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Effect of residues remaining in the injection liner of a gas chromatograph on the quantification of polycyclic aromatic hydrocarbons by isotope dilution mass spectrometry using deuterium-labeled internal standards

Itoh¹,

Numata²,

Aoyagi³

et al. 2006

Journal of Chromatography A

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Influence of solvents and gas chromatographic injector conditions on the detectability of nitroaromatic compounds

Cited by 5 publications

References 9 publications

Development and validation of a gas chromatographic–mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration

Development and validation of a gas chromatographic–mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration

Quenched Phosphorescence Detection in Cyclodextrin-Based Electrokinetic Chromatography

Effect of residues remaining in the injection liner of a gas chromatograph on the quantification of polycyclic aromatic hydrocarbons by isotope dilution mass spectrometry using deuterium-labeled internal standards

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