Influence of sol–gel derived strontium–cerium co-substitution in fluorohydroxyapatite and its in-vitro bioactivity

Sanyal, Vijayalakshmi; Raja, C. Ramachandra

doi:10.1007/s10971-017-4460-6

Cited by 10 publications

(6 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with the observations of some researchers about substituting larger Sr 2+ ions for Ca 2+ ions (Li 2010;Gallo 2011;Wang et al 2019). This is while Sanyal and Raja (2017) reported that FHA and Sr-Ce-FHA compounds synthesized by the sol-gel method had a crystallite size of 60.5 nm and 65.4 nm, respectively. Shokri et al ( 2014) also showed FHA crystallite size that was synthesized by the sol-gel method was 50 nm.…”

Section: X-ray Diffraction Analysissupporting

confidence: 91%

Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment

et al. 2021

View full text Add to dashboard Cite

Titanium and its alloys are considered as appropriate replacements for the irreparable bone. Calcium phosphate coatings are widely used to improve the osteoinduction and osseointegration ability of titanium alloys. To further improve the performance of the calcium phosphate-coated implants, strontium (Sr) was introduced to partially replace the calcium ions. In this study, the effect of Sr ion addition on the fluorohydroxyapatite (FHA)-coated Ti6Al4V alloy was investigated and all the coatings were treated under hydrothermal condition. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to investigate the phases and microstructures, respectively. Shear tests were done to evaluate the bond strength of the coating layer. MTT, adhesion, and alkaline phosphatase tests were performed to evaluate the biocompatibility and osteogenic behavior of the samples. Results showed that the average crystallite size for the strontium-doped FHA samples was 48 nm and the bond strength had increased 13.15% in comparison with FHA-coated samples. Analysis of variance showed p value for all MTT tests at more than 0.322 and there was not any evidence of cell death after 7 days. The results of the ALP test showed that the increase of the cell activity in Sr samples from day 7 to 14 is three times higher than the FHA ones.

show abstract

Section: X-ray Diffraction Analysissupporting

confidence: 91%

Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition to porous scaffolds, HAp has been used as granules, nanocrystals, and injectable pastes, such as the commercially available Ostim® 45 . The in vivo bioactivity of HAp has been improved by substitution with ions, such as Zn, 77 silicon, 78 strontium, 79 and lithium 80 . Some studies have indicated that HAp can effectively substitute autologous grafts 81,82 .…”

Section: Classificationmentioning

confidence: 99%

A novel classification of bone graft materials

2022

View full text Add to dashboard Cite

Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

show abstract

“…Interestingly, Ce-doped (9 at.%) HA coatings, deposited on titanium substrates by DC pulse micro-arc oxidation, exhibited a good biocompatibility in mouse skull MC3T3-E1 cell cultures at 48 h [346]. It is worth noting that the cytotoxicity of Ce could be alleviated by adding Sr as co-dopant [344,387]. Biocompatible Ce-HA could also find applications as a fluorescent probe for cellular imaging or as an antioxidant agent.…”

Section: Cation-substituted Hydroxyapatitesmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

View full text Add to dashboard Cite

High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

show abstract

Influence of sol–gel derived strontium–cerium co-substitution in fluorohydroxyapatite and its in-vitro bioactivity

Cited by 10 publications

References 44 publications

Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment

Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment

A novel classification of bone graft materials

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Contact Info

Product

Resources

About