Influence of sodium alginate and methylcellulose on hydrolysis and physicochemical properties of α-TCP based materials

Czechowska, Joanna; Zima, Aneta; Siek, D.; Ślósarczyk, A.

doi:10.1016/j.ceramint.2018.01.055

Cited by 19 publications

(14 citation statements)

References 34 publications

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“…EDS analysis revealed that the layer was constituted by calcium and phosphorus (Figure ). Similar observations were described by Martinez, Meseguer‐Olmo, Bernabeu‐Esclapez, Velasquez, and De Aza () and Czechowska et al () in the case of α‐TCP‐based bone cements. The ionic exchange initiated at the implant interface is crucial in the integration process of the bone substitute in vivo.…”

Section: Discussionsupporting

confidence: 87%

“…Another important feature in the case of bone implant materials is their microstructure, including a surface topography and a bulk porosity. CaP bone cements generally possess bimodal pore size distribution with pore sizes between 6 nm up to 2–5 μm (Czechowska et al, ; Czechowska, Zima, Siek, & Ślósarczyk, ). The addition of hybrid granules resulted in biomicroconcretes possessing multimodal porosity and macropores up to 30 μm.…”

Section: Discussionmentioning

confidence: 99%

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In vivo behavior of biomicroconcretes based on α‐tricalcium phosphate and hybrid hydroxyapatite/chitosan granules and sodium alginate

Zima

Czechowska

Szponder

et al. 2020

J Biomedical Materials Res

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The current studies provide insights into how predictions based on results of physicochemical and in vitro tests are consistent with the results of in vivo studies. The new biomicroconcrete type materials were obtained by mixing the solid phase, composed of hybrid hydroxyapatite/chitosan granules and highly reactive α‐tricalcium phosphate powder, used as the setting agent. This approach guaranteed a good adhesion of the continuous cement phase to the surface of granules. It has been demonstrated that developed biomicroconcretes are surgically handy, possessed favorable physicochemical and biological properties and can be considered as effective bone implant material. The hierarchical porosity and compressive strength (2–6 MPa) similar to cancellous bone made them suitable for low‐load bearing applications. Despite the fact that final setting times of biomicroconcretes were longer than recommended in the literature (i.e., exceeded 15 min), their short cohesion time allows for a successful implantation in a rabbit femoral defect model. Histological analysis and Raman studies revealed newly formed bone tissues around the sides of implanted materials. Furthermore, the process of neovascularization and reconstruction of the bone tissue, as well as a reverse scaffolding process, was visible. No signs of inflammation or adverse tissue reactions were observed during the experiment.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

In vivo behavior of biomicroconcretes based on α‐tricalcium phosphate and hybrid hydroxyapatite/chitosan granules and sodium alginate

Zima

Czechowska

Szponder

et al. 2020

J Biomedical Materials Res

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“…The αTCP material showed a typical brittle behavior, whereas the biomicroconcretes presented rather a composite-type characteristic, where the granules suppressed or stopped crack propagation. The compressive strength of developed biomicroconcretes is lower in comparison with αTCP-based bone cements and biomicroconcretes studied in our previous research [ 7 , 8 , 38 ]. However, the obtained values fell within a range of values for the compressive strength of cancellous bone (2–12 MPa), and therefore may be sufficient for non-load bearing applications.…”

Section: Resultsmentioning

confidence: 56%

Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes

et al. 2021

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Bioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-modified and modified with gold nanoparticles (AuNPs), were designed. The developed biomicroconcretes were supposed to combine the dual functions of antibacterial activity and bone defect repair. The chemical and phase composition, microstructure, setting times, mechanical strength, and in vitro bioactive potential of the composites were examined. Furthermore, on the basis of the American Association of Textile Chemists and Colorists test (AATCC 100), adapted for chemically bonded materials, the antibacterial activity of the biomicroconcretes against S. epidermidis, E. coli, and S. aureus was evaluated. All biomicroconcretes were surgically handy and revealed good adhesion between the hybrid granules and calcium phosphate-based matrix. Furthermore, they possessed acceptable setting times and mechanical properties. It has been stated that materials containing AuNPs set faster and possess a slightly higher compressive strength (3.4 ± 0.7 MPa). The modification of αTCP with silicon led to a favorable decrease of the final setting time to 10 min. Furthermore, it has been shown that materials modified with AuNPs and silicon possessed an enhanced bioactivity. The antibacterial properties of all of the developed biomicroconcretes against the tested bacterial strains due to the presence of both chitosan and Au were confirmed. The material modified simultaneously with AuNPs and silicon seems to be the most promising candidate for further biological studies.

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“…The alginate addition to α-tricalcium phosphate increased the compressive strength to a greater extent than the addition of methylcellulose. The results indicate that these biomaterials have a potential for bone regeneration applications (Czechowska et al, 2018).…”

Section: New Approaches For Alginate-based Biomaterialsmentioning

confidence: 86%

“…The above-mentioned results are summarized in Table 5. (Shaheen et al, 2019) hydroxyapatite-alginatechlorhexidine increased degree of swelling and decreased shape stability due to alginate content (Sukhodub et al, 2018) poly(lactic-co-glycolic acid)magnesium oxide-alginate coreshell microspheres enhanced MC3T3-E1 pre-osteoblasts viability and new bone formation (75% bone volume) with good Young's modulus of the regenerated bone in Sprague-Dawley female rats (Lin et al, 2018) -tricalcium phosphate-alginate increased compressive strength (Czechowska et al, 2018) alginate/sulfated alginate bioinks good rheologic properties, improved release and activity of BMP2 (MC3T3-E1 osteoblasts -enhanced proliferation and osteogenesis), good results regarding metabolic and ALP activity and calcium deposition; (Park et al, 2018) Calcium/Strontium-alginate enhanced stability and improved proliferation of the hMSCs for higher content of Sr 2+ (Catanzano et al, 2018) Calcium carbonate-alginate improved hydrogel stability and enhanced cell viability for alginate with intermediate content of G blocks (Diaz-Rodriguez et al, 2018) silica-alginate and 3glycidoxypropyl trimethoxysilane rapid silicon release for high contents of 3-glycidoxypropyl trimethoxysilane and decreased dissolution time due to the addition of calcium ions (Vueva et al, 2018) 4.3. Gelatin-based biomaterials…”

Section: New Approaches For Alginate-based Biomaterialsmentioning

confidence: 99%

A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

2018

Biomater Tissue Eng Bull

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Bone diseases and injuries have a major impact on the quality of life. Classical treatments for bone repair/regeneration/replacement have various disadvantages. Bone tissue engineering (BTE) received a great attention in the last years. Natural polymers are intensively studied in this field due to their properties (biocompatibility, biodegradability, abundance in nature, high processability). Unfortunately, their mechanical properties are poor, which is why synthetic polymers or ceramics are added in order to provide the optimal compressive, elastic or fatigue strength. Moreover, growth factors, vitamins, or antimicrobial substances are also added to enhance the cell behavior (attachment, proliferation, and differentiation). In this review, new scientific results regarding potential applications of chitosan-, alginate-, and gelatin based biocomposites in BTE will be provided, along with their in vitro and/or in vivo tests.

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Influence of sodium alginate and methylcellulose on hydrolysis and physicochemical properties of α-TCP based materials

Cited by 19 publications

References 34 publications

In vivo behavior of biomicroconcretes based on α‐tricalcium phosphate and hybrid hydroxyapatite/chitosan granules and sodium alginate

In vivo behavior of biomicroconcretes based on α‐tricalcium phosphate and hybrid hydroxyapatite/chitosan granules and sodium alginate

Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes

A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

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