Influence of smoking on caffeine elimination in healthy volunteers and in patients with alcoholic liver cirrhosis

Joeres, R.; Klinker, Hartwig; Heusler, H.; Epping, J.; Zilly, W.; Richter, E.

doi:10.1002/hep.1840080323

Cited by 78 publications

(35 citation statements)

References 18 publications

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“…Experimental work in animal and human subjects has found evidence for causal effects in both directions. Smoking may increase caffeine use causally because nicotine in inhaled cigarette smoke increases the metabolism of caffeine 26, 27, 28. In the other direction, it was found that rats consuming caffeine in their drinking water self‐administered significantly more nicotine than did controls.…”

Section: Discussionmentioning

confidence: 99%

Associations between smoking and caffeine consumption in two European cohorts

et al. 2016

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AimsTo estimate associations between smoking initiation, smoking persistence and smoking heaviness and caffeine consumption in two population‐based samples from the Netherlands and the United Kingdom.DesignObservational study employing data on self‐reported smoking behaviour and caffeine consumption.SettingAdults from the general population in the Netherlands and the United Kingdom.ParticipantsParticipants from the Netherlands Twin Register [NTR: n = 21 939, mean age 40.8, standard deviation (SD) = 16.9, 62.6% female] and the Avon Longitudinal Study of Parents and Children (ALSPAC: n = 9086, mean age 33.2, SD = 4.7, 100% female).MeasurementsSmoking initiation (ever versus never smoking), smoking persistence (current versus former smoking), smoking heaviness (number of cigarettes smoked) and caffeine consumption in mg per day through coffee, tea, cola and energy drinks.FindingsAfter correction for age, gender (NTR), education and social class (ALSPAC), smoking initiation was associated with consuming on average 52.8 [95% confidence interval (CI) = 45.6–60.0; NTR] and 59.5 (95% CI = 51.8–67.2; ALSPAC) mg more caffeine per day. Smoking persistence was also associated with consuming more caffeine [+57.9 (95% CI = 45.2–70.5) and +83.2 (95% CI = 70.2–96.3) mg, respectively]. Each additional cigarette smoked per day was associated with 3.7 (95% CI = 1.9–5.5; NTR) and 8.4 (95% CI = 6.9–10.0; ALSPAC) mg higher daily caffeine consumption in current smokers. Smoking was associated positively with coffee consumption and less strongly with cola and energy drinks. For tea, associations were positive in ALSPAC and negative in NTR.ConclusionsThere appears to be a positive association between smoking and caffeine consumption in the Netherlands and the United Kingdom.

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Section: Discussionmentioning

confidence: 99%

Associations between smoking and caffeine consumption in two European cohorts

et al. 2016

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“…Participants (N = 16) were nonsmoking college-age women of average body weight who reported low to moderate daily caffeine consumption (i.e., ≤200 mg/day) and no hypersensitivity to caffeine. Only nonsmokers of average body weight (i.e., BMI ≤25) were recruited to avoid the effects of cigarette smoking (Joeres et al, 1988) and obesity (Kamimori, Somani, Knowlton, & Perkins, 1987) on the rate of caffeine metabolism. Participants who reported low to moderate daily caffeine consumption were recruited to minimize tolerance of the effects of caffeine among habitual consumers of caffeine (Laska et al, 1984).…”

Section: Participantsmentioning

confidence: 99%

Effect of Caffeine on Leg-Muscle Pain during Intense Cycling Exercise: Possible Role of Anxiety Sensitivity

Gliottoni¹,

Motl²

2008

International Journal of Sport Nutrition and Exercise Metabolism

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This experiment examined the effect of a moderate dose of caffeine on perceptions of leg-muscle pain during a bout of high-intensity cycling exercise and the role of anxiety sensitivity in the hypoalgesic effect of caffeine on muscle pain during exercise. Sixteen college-age women ingested caffeine (5 mg/kg body weight) or a placebo and 1 hr later completed 30 min of cycling on an ergometer at 80% of peak aerobic capacity. The conditions were completed in a counterbalanced order, and perceptions of leg-muscle pain were recorded during the bouts of exercise. Caffeine resulted in a large reduction in leg-muscle pain-intensity ratings compared with placebo (d = −0.95), and the reduction in leg-muscle pain-intensity ratings was larger in those with lower anxiety-sensitivity scores than those with higher anxiety-sensitivity scores (d = −1.28 based on a difference in difference scores). The results support that caffeine ingestion has a large effect on reducing leg-muscle pain during high-intensity exercise, and the effect is moderated by anxiety sensitivity.

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“…The diterpenes cafestol and kahweol (non-triglyceride lipids present in coffee) are shown to be responsible for the hypercholesterolemic effects of boiled coffee 9,12) , and cafestol has been shown to decrease serum liver enzymes 9) . We did not obtain information regarding brewing methods of coffee, but instant coffee is most popular in Japan, followed by brewed (mostly filtered) coffee, whereas use of unfiltered coffee is virtually absent 13) .…”

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confidence: 99%