Influence of sex-based differences on oral anticoagulation control in patients taking coumarin derivatives: a systematic review protocol

Viana, Catiane Costa; Praxedes, Marcus Fernando da Silva; Sousa, Waleska Jaclyn Freitas Nunes de; Bartolazzi, Frederico; Silva, José Luiz Padilha da; Martins, Maria Auxiliadora Parreiras

doi:10.11124/jbies-20-00168

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…18 We complied with the Joanna Briggs Institute's methodology for systematic reviews of effectiveness evidence 19 and the study protocol has been described elsewhere. 20 The protocol was published on the PROSPERO website (https:// www.crd.york.ac.uk/prospero/) under registration code CRD42019 128329. (5) oral anticoagulation with warfarin or other coumarin derivative used for ≥3 months; (6) any indication for long-term use; (7) quality of oral anticoagulation measured by TTR, calculated by the Rosendaal method, reported separately for men and women.…”

Section: This Systematic Review Followed the Recommendations Of Preferredmentioning

confidence: 99%

Sex‐influence on the time in therapeutic range (TTR) during oral anticoagulation with coumarin derivatives: Systematic review and meta‐analysis

Viana

Praxedes

Sousa

et al. 2021

Brit J Clinical Pharma

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Aims: We sought to investigate the association between sex and oral anticoagulation control employing coumarin derivatives.Methods: Electronic sources were MEDLINE, Biblioteca Virtual em Saúde (BVS), The Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, Cochrane Central and Web of Science. Inclusion criteria were: observational and experimental studies; age ≥18 years; both sexes; treatment with any coumarin derivative for ≥3 months; any indication of long-term use; quality of oral anticoagulation measured by time in therapeutic range (TTR). The meta-analysis was developed with odds ratios (OR) for binary variables and mean differences (MD) for continuous variables, using random-effects models (DerSimonian and Laird) with 95% confidence intervals (CI).Results: Overall, 22 articles were selected, comprising 16 cohort studies, four crosssectional studies and two clinical trials. The number of participants ranged from 110 to 104 505 (183 612; women: 45%). The main indication of oral anticoagulation was atrial fibrillation. Most studies reported the use of warfarin. In the meta-analysis, 15 studies were analysed using TTR as a binary variable (OR = 0.87; 95% CI = 0.78, 0.96; z = À2.75; P = .006.; I 2 = 67%) and seven studies as a continuous variable (MD = À2.97; 95% CI = À4.80, À1.14; z = À3.19; P = .0014; I 2 = 75%). The pooled estimates indicated that women were associated with lower TTR than men.Conclusions: Our findings revealed an association between female sex and worse oral anticoagulation control. Further studies are needed with primary design to investigate sex-related factors influencing oral anticoagulation control with coumarin derivatives. Innovative strategies focused on women's health may be useful to improve patient-centred care.

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Section: This Systematic Review Followed the Recommendations Of Preferredmentioning

confidence: 99%

Sex‐influence on the time in therapeutic range (TTR) during oral anticoagulation with coumarin derivatives: Systematic review and meta‐analysis

Viana

Praxedes

Sousa

et al. 2021

Brit J Clinical Pharma

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“…Coumarins are a class of bioactive molecules that are also known as cis-O-hydroxycinnamic lactones and possess a benzoα-pyranone moiety in their basic structure (Küpeli Akkol et al, 2020;Salehian et al, 2021). They are secondary metabolites found in plants, bacteria, and fungi, with approximately 1,300 types of coumarins recognized so far (Stefanachi et al, 2018;Viana et al, 2021). Coumarin-based compounds have gained increasing attention due to their broad range of biological activities (Ahmed et al, 2020;Küpeli Akkol et al, 2020;Wu et al, 2020;Rawat and Vijaya Bhaskar Reddy, 2022).…”

Section: Introductionmentioning

confidence: 99%

Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for targeted treatment of hepatocellular carcinoma

Radwan,

Abo-Elabass,

Abd El-Baky

et al. 2023

Front. Chem.

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Being the sixth most diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide, liver cancer is considered as a serious disease with a high prevalence and poor prognosis. Current anticancer drugs for liver cancer have drawbacks, such as limited efficacy in later stages of the disease, toxicity to healthy cells, and the potential for drug resistance. There is ample evidence that coumarin-based compounds are potent anticancer agents, with numerous analogues currently being investigated in preclinical and clinical studies. The current study aimed to explore the antitumor potency of a new class of 8-methoxycoumarin-3-carboxamides against liver cancer. Toward this aim, we have designed, synthesized, and characterized a new set of N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamide analogues. The assessment of antitumor activity revealed that the synthesized class of compounds possesses substantial cytotoxicity toward Hep-G2 cells when compared to staurosporine, without significant impact on normal cells. Out of the synthesized compounds, compound 7 demonstrated the most potent cytotoxic effect against Hep-G2 cells with an IC50 of 0.75 µM, which was more potent than the drug staurosporine (IC50 = 8.37 µM). The investigation into the mechanism behind the antiproliferative activity of compound 7 revealed that it interferes with DNA replication and induces DNA damage, leading to cell cycle arrest as demonstrated by a significant decrease in the percentage of cells in the G1 and G2/M phases, along with an increase in the percentage of cells in the S phase. Flow cytometric analysis further revealed that compound 7 has the ability to trigger programmed cell death by inducing necrosis and apoptosis in HepG-2 cells. Further explorations into the mechanism of action demonstrated that compound 7 displays a potent dual-inhibitory activity toward cytochrome P450 and vascular endothelial growth factor receptor-2 (VEGFR-2) proteins, as compared to sorafenib drug. Further, detailed computational studies revealed that compound 7 displays a considerable binding affinity toward the binding cavity of VEGFR2 and CYP450 proteins. Taken together, our findings indicate that the newly synthesized class of compounds, particularly compound 7, could serve as a promising scaffold for the development of highly effective anticancer agents against liver cancer.

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“…[6] Coumarin compounds have drawn a lot of attention in the last several years. Coumarin and its derivatives have a variety of pharmacological effects, such as anticoagulant, [7][8][9][10] antibacterial, [11][12][13] anti-inflammatory, [14][15][16][17] antioxidant, [18][19][20] anticancer, [21][22][23][24] antiviral, [25][26][27][28] anti-diabetic, and enzyme inhibitory effect [29][30][31][32][33][34][35] A recent study, however, advises researchers to look for coumarins or other compounds that could be able to lower blood glucose levels. For example, coumarins have been shown in multiple studies examining the connection between structure and activity to bind to the active sites of the enzymes glucosidase and aldose reductase.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 7‐{[2‐(4‐ substituted phenyl)‐2‐oxoethyl] amino}‐4‐methyl‐2H‐1‐benzopyran‐2‐one derivatives and evaluation of their pharmacological activities

Megha,

Bodke

2024

ChemistrySelect

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In this study, a novel series of 7‐[2‐(4‐substituted)‐2‐oxoethyl]amino‐4‐methyl‐2H‐1‐benzopyran‐2‐one derivatives (3 a‐f) were synthesized using 7‐amino‐4‐methyl coumarin and p‐substituted phenacyl bromides, and their pharmacological effects were examined. This reaction was carried out with potassium carbonate as a catalyst in dimethylformamide for 24 h at ambient temperature. The structures of synthesized compounds have been characterized by analysis using FTIR, NMR (1H and 13C) and Mass spectroscopic techniques, and their antibacterial, antidiabetic, and anti‐inflammatory properties have been explored. All synthesized compounds have exhibited good antibacterial activity against S. aureus, B. substilis, E. coli, and S. typhi.Compound 3 f shows maximum activity (zone of inhibition) at a 12 g/mL concentration compared to others. Compounds 3 c and 3 f showed excellent α‐amylase activity and had the lowest IC50 values for α‐glucosidase enzyme activities. The least IC50 value (12.42±0.27 g/mL) was demonstrated by the 3 e compound, which exhibited potent anti‐inflammatory activities. in silico Molecular docking studies suggested that compounds 3 f and 3 a interacted effectively with 4DO3: FAAH and 5DI1: MAP4 K4 proteins with good binding energies of −10.3 and −9.5 Kcal/mol, respectively.

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Influence of sex-based differences on oral anticoagulation control in patients taking coumarin derivatives: a systematic review protocol

Cited by 4 publications

References 24 publications

Sex‐influence on the time in therapeutic range (TTR) during oral anticoagulation with coumarin derivatives: Systematic review and meta‐analysis

Sex‐influence on the time in therapeutic range (TTR) during oral anticoagulation with coumarin derivatives: Systematic review and meta‐analysis

Unveiling the antitumor potential of novel N-(substituted-phenyl)-8-methoxycoumarin-3-carboxamides as dual inhibitors of VEGFR2 kinase and cytochrome P450 for targeted treatment of hepatocellular carcinoma

Synthesis of 7‐{[2‐(4‐ substituted phenyl)‐2‐oxoethyl] amino}‐4‐methyl‐2H‐1‐benzopyran‐2‐one derivatives and evaluation of their pharmacological activities

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