Influence of Radiation Exposure and Ultrasound Screening on the Clinical Behavior of Papillary Thyroid Carcinoma in Young Patients

Rumiantsev, Pavel O.; Saenko, Vladimir; Дедов, И И

doi:10.1016/b978-0-12-812768-1.00010-1

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…It was the thyroid system that turned out to be the most sensitive to the results of the Chornobyl accident with early observed effects (Popovych et al, 2003). The risk of development of thyroid gland pathologies is considered to be high enough both by scientists and doctors, despite the long time that has passed since the radiation catastrophe, it concerns both acute and chronic exposure (Cardis & Hatch, 2011;Takamura et al, 2016;Boice, 2017;Rumiantsev et al, 2017). A special risk group is the people who were 0-5 at the time of the accident, which indicates the high vulnerability of this age group to radiation exposure.…”

Section: Introductionmentioning

confidence: 99%

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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We have studied the interdependence of the intensity of oxidative processes/antioxidant level and the thyroid status parameters in a group of students aged 18–24 who lived for a long time in the territory of enhanced radioecological control (density of soil contamination by isotopes (137Cs 3.7 ∙ 104 – 18.5 ∙ 104 Bq/m2). We examined 50 people from relatively environmentally friendly areas (control group) and 50 people from IV radiation zone (experimental group). In the experimental group, there were no individuals with clinical manifestations of thyroid pathology. However, subgroups with signs of hyperthyroidism and hypothyroidism were identified. We evaluated the level of cortisol, thyrotrophic hormone (TSH), triiodothyronine (T3), thyroxine (T4), malonic dialdehyde (MDA), ceruloplasmin (CP), transferrin (Tf), sulfhydryl groups (SH); we calculated the oxidative stress index (OSI). The research was conducted one month before the examination time and also during the exams as a factor in increased emotional stress. A lowered CP level was found in the subgroup with signs of hypothyroidism; SH groups – in all subgroups, separated by thyroid status. The oxidative stress index was higher in all students examined of the experimental group, compared with the control. The growth of MDA level is marked in the experimental group – it is the most strongly pronounced in conditions of additional emotional load in people with signs of hyperthyroidism and hypothyroidism. CP level significantly decreased in the subgroup of hyperthyroidism on the background of T3 decrease. OSI increased in all students examined from the experimental group. In the subgroup of hypothyroidism it became significantly higher than in the subgroup of euthyroidism. A positive correlation between the levels of CP and T3 was found. The highest values of the correlation coefficients were noted for subgroups with signs of hyperthyroidism and hypothyroidism, with the coefficient significance increasing under conditions of emotional stress. The index of oxidative stress in the experimental group positively correlated with the level of TSH – in terms of emotional stress, the statistical significance of the coefficients disappeared. In the subgroups divided by thyroid status, variability of interactions between OSI and T3 was observed but it was not statistically significant. It was found that the participation of thyroid status in supporting redox homeostasis in people aged 18–24 who suffered from chronic small-doze radiation exposure was realized mainly by the influence on the antioxidant system. The ability of thyroid hormones to maintain a proper antioxidant state was suppressed in this group. The unbalanced relationship between thyroid hormones and oxidative stress indicators is strongly manifested under conditions of additional emotional stress.

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Section: Introductionmentioning

confidence: 99%

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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“…Досвід Фукусіми підтвердив: навіть за малих доз опромінення зростає рівень тривожності населення щодо раку щитоподібної залози. Це вимагає постійного скринінгу груп ризику (Cardis and Hatch, 2011;Takamura et al, 2016;John et al, 2017;Rumiantsev et al, 2017).…”

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The interaction between lipid exchange and thyroid status in the conditions of prolonged influence of small doses of radiation

Sokolenko

2017

Regul. Mech. Biosyst.

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We studied the interaction between the indicators of lipid exchange and thyroid status among the inhabitants of radiation contaminated territories under additional psycho-emotional load. We observed 170 students aged between 18–24 and divided them into a control group of students who were from areas unaffected by radiation (70 people) and the main experimental group of students from territories of increased radio-ecological load (IV radiation zone, 100 people). We determined the content of thyrotropic hormone (TTH), triiodothyronine (T3), thyroxin (T4), total cholesterin (TC), triglycerides (TG), cholesterin of lipoproteins of high density (Ch-LPHD) and cholesterin of lipoproteins of low density (Ch-LPLD). We found that people who had lived since birth in territories which were contaminated with radionuclides and were affected by prolonged influence of small doses of ionizing radiation had significant fluctuations of indicators of concentrations of TTH, T3 and T4, forming manifestations of hypothyroidism and hyperthyrosis among some of those tested. Independently from hyperthyrosis, the effect was accompanied by growth in the level of TH, TG, Ch-LPHD and Ch-LPLD. Persons with manifestations of hypothyroidism had the content of TH above the upper limit of the homeostatic norm and the level of Ch-LPLD was higher than the norm in sub-groups with features of hypo- and hyperthyrosis. All those tested from the main group showed a significant positive correlation connection between the level of TTH and levels of TH and Ch-LPLD. The subgroup with manifestations of hyperthyrosis had a positive correlation between the levels of TTH and TG, the subgroups with manifestations of euthyroidism and hyperthyrosis had a negative correlation between the levels of TTH and Ch-LPHD. The hyperthyrosis subgroup had a significant positive correlation connection between T3 and TH and Ch-LPLD. The euthyroidism and hypothyroidism subgroups had a significant negative correlation between T3 concentration and Ch-LPLD. The cortisol indicator positively correlated with levels of TH and Ch-LPLD in all subgroups divided according to thyroid status. In the conditions of additional psycho-emotional load (examinations), those tested had an increased level of TP (higher than the norm in the subgroups of hyperthyrosis and hypothyroidism) caused by the increase in cortisol level and a tendency of decrease in TTH. At the same time, the level of Ch-LPLD increased (higher than the upper norm) as a result of decrease in the content of Ch-LPHL. The coefficient of correlation between the level of TTH and levels of TH and Ch-LPLD lost statistical significance in all subgroups divided according to thyroid status. In the hyperthyrosis subgroup, the effect of loss of correlation with TH and Ch-LPLD was also observed for T3. Thus, the individuals tested from territories polluted by radionuclides, had proaterogenic changes dependant on thyroid status,which can become a precondition for the development of metabolic syndrome. The risk of dyslipidemia increases in the conditions of additional psycho-emotional load, when the regulatory effect of the thyroid gland`s hormones is reduced.

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Influence of Radiation Exposure and Ultrasound Screening on the Clinical Behavior of Papillary Thyroid Carcinoma in Young Patients

Cited by 2 publications

References 3 publications

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

The interaction between lipid exchange and thyroid status in the conditions of prolonged influence of small doses of radiation

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