Influence of protein deficiency on cadmium toxicity in rats

Tewari, Prakash C.; Jain, V. K.; Ashquin, Mohd; Tandon, S. K.

doi:10.1007/bf01066408

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Antioxidant therapies have also been reported to exert protective effects on Cd toxicity (Kowalczyk et al 2003;El-Demerdash et al 2004;Morales et al 2006;Asagba et al 2007;Massadeh et al 2007). Furthermore, some studies have provided evidence linking the severity of cadmium-related pathologies to nutritional deficiencies (Tewari et al 1986;Alfven et al 2000;Asagba et al 2004). These suggest that dietary factors may play a key role in the severity of Cd toxicity.…”

Section: Introductionmentioning

confidence: 92%

Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats

Suru

2008

Biometals

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Cadmium (Cd) is a well-known nephrotoxicant inducing kidney damage via oxidative stress. Since kidney is the critical target organ of Cd toxicity, this study was designed to evaluate the protective effects of onion (Allium cepa L.) and garlic (Allium sativum L.) aqueous extracts on Cd-induced renal oxidative stress in male Wistar rats. The control group received double distilled water alone and Cd group was challenged with 3CdSO 4 Á 8H 2 O (as Cd) (1.5 mg/ 100 g bw/day per oral) alone. Extract-treated groups were pre-treated with varied doses (0.5 ml and 1.0 ml/ 100 g bw/day per oral) of onion and/or garlic extract for 1 week after which they were co-treated with Cd (1.5 mg/100 g bw/day per oral) for 3 weeks. The results showed that the levels of renal lipid peroxidation (LPO) and glutathione-S transferase (GST) were significantly (P \ 0.001) increased in rats that received Cd alone relative to the control group. More so, the levels of renal glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and Na + /K + -ATPase were significantly (P \ 0.001) decreased in rats that received Cd alone. Treatment of Cd-intoxicated rats with varied doses of onion and/or garlic extract significantly (P \ 0.05) restored the alterations in these parameters relative to the group that received Cd alone. While treatment with high dose of onion extract exerted a significant dose-dependent restoration of these parameters, treatment with high dose of garlic elicited a pro-oxidant effect, relative to their respective low dose. Our study suggests that onion and garlic extracts may exert their protective effects via reduction in LPO and enhanced antioxidant defense. These extracts may, therefore, be useful nutritional option in alleviating Cd-induced renal damage.

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Section: Introductionmentioning

confidence: 92%

Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats

Suru

2008

Biometals

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“…The exposure to Cd causes induction of hepatic and renal metallothionein (MT) (Nordberg, 1978), trace metal imbalance and alterations in carbohydrate metabolism (Stonard and Webb, 1976;Tewari et al,1986). The alterations in trace metal levels, induction of MT and uptake of Cd have been observed in experimental diabetic rats (Failla and Kiser, 1981, 983;Ithakissios et al, 1974).…”

Section: Introductionmentioning

confidence: 98%

“…The increase in hepatic and renal concentrations of Cd, Zn and Cu is apparently due to the induction of metallothionein biosynthesis by Cd. The depletion of liver and kidney Fe is also a prominent effect of Cd, as it inhibits the intestipal uptake of Fe (Tewari et al, 1986). The intracellular distribution of Cd renders the removal of Cd by chelating agents very difficult, even within an hour of Cd administration (Waalkes et al, 1983).…”

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confidence: 99%

Influence of Glibenclamide On the Efficacy of Calcium Trisodium Pentetat as an Antidote for Cadmium Toxicity

Tewari

Tandon

1988

Toxicol Ind Health

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Cadmium causes hyperglycemia, activation of hepatic and renal gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-diphosphatase, increases hepatic and renal zinc, renal copper and decreases hepatic and renal iron levels in rats. Glibenclamide, a hypoglycemic agent, significantly reversed most of the Cd effects, enhanced fecal excretion of Cd and potentiated urinary and fecal elimination of Cd by calcium trisodium diethylenetriaminepentaacetate (CaNa3DTPA), a commonly used metal chelator. However, the restoration of Cd-induced alterations in carbohydrate metabolism was not related to elimination of Cd from the tissues.

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