Influence of Pleurotus djamor Bioactive Substances on the Survival Time of Mice Inoculated with Sarcoma 180

Fungi of Pleurotus genus have attracted a great interest due to their medicinal properties such as antiinflammatory, antimicrobial and antitumor. These properties are attributed mainly to polysaccharides synthesized by Pleurotus. This work aimed to study the mycelial growth of P. ostreatus in submerged culture, evaluating the influence of the initial concentration of substrate (20 and 40 g/L of glucose) and the pH (4 and 6) on kinetic parameters of production of biomass. The effectiveness of different doses (10, 30 and 50 mg/kg) of a mycelium polysaccharide fraction extracted from P. ostreatus in reducing Sarcoma 180 development in mice was also verified. In the range of this study, maximum concentration of mycelial biomass (about 12.8 g/L) was obtained using 40.0 g/L of glucose, at pH 4.0. The total biomass productivity (Px) was not significantly affected by substrate concentration and pH, reaching values of 0.034 g/L.h. Sarcoma 180 tumor weight was reduced in 74.1, 75.5 and 53.7% when 10, 30 and 50 mg/kg were administered, respectively. These results show the high antitumor potential of intracellular polysaccharide fraction of mycelial biomass of P. ostreatus, particularly at lower doses of 10 and 30 mg/kg.

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Influence of Pleurotus djamor Bioactive Substances on the Survival Time of Mice Inoculated with Sarcoma 180

Cited by 4 publications

References 19 publications

Polysaccharides of mushroom Pleurotus spp.: New extraction techniques, biological activities and development of new technologies

Polysaccharides of mushroom Pleurotus spp.: New extraction techniques, biological activities and development of new technologies

Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor

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