Influence of Phosphoserine on the Performance of Rats on the Rotarod

Abstract

The anti-fatigue effect of phosphoserine, L-serine and a mixture of sodium phosphate and L-serine has been studied in rats. Phosphoserine orally administered induced a statistically significant anti-fatigue effect in rats of both sexes submitted to a training test by rotarod, with 14 sessions in 3 days. Furthermore, phosphoserine was utilized better than the mixture of sodium phosphate and L-serine, whereas L-serine alone induced no effect. Therefore, the effect of phosphoserine seems to be due to the phosphoryl bond.

RNA and Protein Synthesis in Rat Brain during Exercise

“…In conclusion, the stimulation of brain macromolecular synthesis elicited by arginine or phosphorylated amino acids in stressed ani mals could account for the anti-fatigue effect exerted by the same substances, as shown in other studies (Fanelli, 1976). This ability of the investigated compounds to partially reverse the stress-inducing inhibitory effect on the rate of brain macromolecular synthesis could account for the recovery functions of the central ner vous cells exposed to stress.…”

“…In view of these considerations, we decided to study the effect produced by oral administration of some phosphorylated amino acids and arginine on brain RNA and protein synthesis in swimming rats. In fact, phosphoserine and phosphothreonine, which are necessary for phospholipid synthesis in the central nervous cells (Porcellati, 1964), improve the performance of training rats (Fanelli, 1976), while arginine as the polyamine (Bachrach, 1973) as well as GABA precursor (, Seiler and Al-Therib, 1974) most probably stimulates brain macromolecular synthesis.…”