RNA and Protein Synthesis in Rat Brain during Exercise

Guarnieri, Carlo; Fussi, F; Fanelli, O; Davalli, Pierpaola; Clô, Carlo

doi:10.1159/000137282

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…The over-representation of the oxidative phosphorylation and cellular respiration processes among the genes over-expressed in Co relative to Hi mice (Tables 3 and 4 ) is consistent with reports that regular exercise decreases the level of reactive oxygen species and modulates protein oxidation in the brain of adult rats [ 72 , 73 ]. Likewise, the enrichment of the KEGG ribosome pathway among the genes over-expressed in Co relative to Hi mice is consistent with work demonstrating that protein synthesis is noticeably depressed in the brain of swimming rats [ 74 ]. The enrichment of Parkinson’s disease in Hi relative to Co is in agreement with a large body of studies in rodent models and humans suggesting that exercise can protects the brain against such neurodegenerative conditions [ 75 – 77 ].…”

Section: Resultssupporting

confidence: 86%

Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior

et al. 2018

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Mouse lines selectively bred for high voluntary wheel-running behavior are helpful models for uncovering gene networks associated with increased motivation for physical activity and other reward-dependent behaviors. The fact that multiple brain regions are hypothesized to contribute to distinct behavior components necessitates the simultaneous study of these regions. The goals of this study were to identify brain-region dependent and independent gene expression patterns, regulators, and networks associated with increased voluntary wheel-running behavior. The cerebellum and striatum from a high voluntary running line and a non-selected control line were compared. Neuropeptide genes annotated to reward-dependent processes including neuropeptide S receptor 1 (Npsr1), neuropeptide Y (Npy), and proprotein convertase subtilisin/kexin type 9 (Pcsk9), and genes implicated in motor coordination including vitamin D receptor (Vdr) and keratin, type I cytoskeletal 25 (Krt25) were among the genes exhibiting activity line-by-region interaction effects. Genes annotated to the Parkinson pathway presented consistent line patterns, albeit at different orders of magnitude between brain regions, suggesting some parallel events in response to selection for high voluntary activity. The comparison of gene networks between brain regions highlighted genes including transcription factor AP-2-delta (Tfap2d), distal-less homeobox 5 gene (Dlx5) and sine oculis homeobox homolog 3 (Six3) that exhibited line differential expression in one brain region and are associated with reward-dependent behaviors. Transcription factors including En2, Stat6 and Eomes predominated among regulators of genes that differed in expression between lines. Results from the simultaneous study of striatum and cerebellum confirm the necessity to study molecular mechanisms associated with voluntary activity and reward-dependent behaviors in consideration of brain region dependencies.

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