Influence of phase I periodontal therapy on levels of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase 1

Ghodpage, Pallavi S.; Kolte, Rajashri A; Kolte, Abhay; Gupta, Madhur

doi:10.1016/j.sdentj.2014.05.003

Cited by 19 publications

(19 citation statements)

References 22 publications

(28 reference statements)

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“…These results were in accordance with Ghodpage (18) ; Lamster and Ahlo (19) . They revealed statistically significant differences between chronic periodontitis patients at baseline and healthy subjects regarding the same clinical parameters.…”

Section: Discussion:-supporting

confidence: 91%

Clinical and Laboratory Evaluation of Adrenomedullin as a Biomarker in Moderate Chronic Periodontitis.

Salim¹,

Youssef²,

Salah³

et al. 2017

IJAR

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Section: Discussion:-supporting

confidence: 91%

Clinical and Laboratory Evaluation of Adrenomedullin as a Biomarker in Moderate Chronic Periodontitis.

Salim¹,

Youssef²,

Salah³

et al. 2017

IJAR

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“…MMP‐1 is considered the prototype for all the interstitial collagenases and plays a key role in both physiological and pathological tissue remodeling (Vincenti and Brinckerhoff, ; Pardo and Selman, ). MMP‐1 has been implicated in periodontitis as recent studies showed that patients with periodontitis had a substantial elevation of MMP‐1 in GCF as compared to periodontally healthy subjects (Popat et al , ) and treatment of periodontitis with scaling and root planning was associated with a reduced MMP‐1 in GCF (Ghodpage et al , ). Furthermore, the importance of MMP‐1 in periodontitis was underscored by a recent meta‐analysis on the association between MMP‐1 polymorphism and periodontitis susceptibility (Li et al , ).…”

Section: Discussionmentioning

confidence: 99%

Statin intake is associated with MMP‐1 level in gingival crevicular fluid of patients with periodontitis

Poston

Pierce

et al. 2016

Oral Diseases

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BACKGROUND This study was conducted to assess if statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of nondiabetic and diabetic patients. METHODS We first determined the effect of simvastatin on MMP expression in mononuclear cells. We then recruited 117 nondiabetic and diabetic patients, who all had periodontitis and took or did not take statin, and measured periodontal probing depth (PPD) and clinical attachment level (CAL), and collected gingival crevicular fluid (GCF) to quantify MMPs. RESULTS The in vitro studies showed that simvastatin potently inhibited the expression of MMP-1, -8, and -9 upregulated by lipopolysaccharide (LPS) and high glucose in mononuclear cells. The patient study showed that, after adjusting for age and smoking status, PPD in diabetic patients on statin was significantly less than that in diabetic patients not on statin. MMP-1 level in GCF of nondiabetic and diabetic patients on statin was lower than that of nondiabetic and diabetic patients not on statin, respectively. No difference was found for MMP-8 and -9 levels in GCF. CONCLUSION Statin intake is associated with reduced PPD in diabetic patients and MMP-1 level in GCF in either nondiabetic or diabetic patients.

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“…Therefore, the development of noninvasive diagnostic biomarkers for bladder malignancies is mandatory. [6] In the present study, blood and urine levels of MMP-2 and MMP-9, as well as TIMP-2 were assessed by western blot analysis and by realtime polymerase chain reaction (PCR) to measure expression levels of the proteins and genes, respectively. The extracellular matrix (ECM) is a major barrier to tissue invasion.…”

Section: Introductionmentioning

confidence: 99%

MMP‐2 and MMP‐9 as prognostic markers for the early detection of urinary bladder cancer

Fouad

Salem

Ellakwa

et al. 2018

J Biochem & Molecular Tox

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The present study assessed protein and gene expression levels of tissue inhibitor of metalloproteinase‐2 (TIMP‐2), matrix metalloproteinase‐2 (MMP‐2), and MMP‐9 in urine and blood samples of 50 patients with bladder carcinoma. The expression of TIMP‐2, MMP‐2, and MMP‐9 levels with tumor stage and grade was also assessed. Results showed that the expression levels of MMP‐2 and MMP‐9 in both blood and urine were significantly elevated in group 1 when compared with groups 2 and 3 healthy subjects. The discriminatory ability in the diagnosis of bladder carcinoma of MMP‐2 and MMP‐9 expression was confirmed by receiver operating characteristic curve analysis that revealed a sensitivity and specificity of 100%. MMP‐2 and MMP‐9 levels were not correlated with grade or stage of the tumor. With respect to TIMP‐2 blood and urine levels, results showed a significant decrease in gene expression levels in bladder carcinoma group, whereas, TIMP‐2 protein showed a significant increase in bladder carcinoma.

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Influence of phase I periodontal therapy on levels of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase 1

Cited by 19 publications

References 22 publications

Clinical and Laboratory Evaluation of Adrenomedullin as a Biomarker in Moderate Chronic Periodontitis.

Clinical and Laboratory Evaluation of Adrenomedullin as a Biomarker in Moderate Chronic Periodontitis.

Statin intake is associated with MMP‐1 level in gingival crevicular fluid of patients with periodontitis

MMP‐2 and MMP‐9 as prognostic markers for the early detection of urinary bladder cancer

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