Influence of Perinatal Factors and Sampling Methods on TSH and Thyroid Hormone Levels in Cord Blood.

Fuse, Y; Wakae, Eriko; Nemoto, Yasuo; Uga, Naoki; Tanaka, Masanobu; Maeda, Mitsushi; Tada, Hiroshi; Miyachi, Yukitaka; Irie, Minoru

doi:10.1507/endocrj1954.38.297

Cited by 33 publications

(44 citation statements)

References 9 publications

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“…These observations were similar to those observed by Shi LX , 8 Beilawski J et al, 9 Fuse Y et al, 10 Eltom A et al 11 In our study cases were classified in three group as per the Sarnat and Sarnat staging of hypoxic ischemic encephalopathy (HIE), 13.33%were in stage I, i.e. mild, 50% were in stage II i.e.…”

Section: Discussionsupporting

confidence: 90%

A Study of Effect of Perinatal Asphyxia on Thyroid Hormone in Neonates

Tikkas¹,

Pal²,

Garg³

2015

jemds

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AIMS AND OBJECTIVE:To study the effect of perinatal asphyxia on thyroid hormones of term neonates. MATERIAL AND METHODS: It was a prospective case control study and it was conducted in department of pediatrics, Kamala Nehru Hospital Gandhi Medical College, Bhopal. Total 60 full term neonates who have completed 37 wks of gestation at birth included in study, 30 asphyxiated newborn taken as cases and 30 healthy neonates as control. For inclusion of cases criteria was, 1 and 5 minute APGAR score <7 and Control were selected with criteria of 1-minute APGAR score >7 and no sepsis setting. Classification of HIE done on the bases of Sarnat and Sarnat staging. Blood samples were collected for determination of thyroid profile (T4, T3 and TSH), first within 6 hours of birth and seconds 18 to 24hour of age. RESULT: Out of 30 cases, 13.13% were HIE-I, 50% were HIE-II and 36.67% were HIE-III. Mean value of TSH was low at 6 hours as well as at 18-24 hours between case and control group while mean value of T3 andT4 were low at only 18-24hrs of age. CONCLUSION: The mean T3, T4 and TSH levels at birth of asphyxiated newborn was significantly lower than the control group at 18-24 hours. Due to low TSH surge, asphyxiated babies could not increase their T3 and T4 level significantly.

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Section: Discussionsupporting

confidence: 90%

A Study of Effect of Perinatal Asphyxia on Thyroid Hormone in Neonates

Tikkas¹,

Pal²,

Garg³

2015

jemds

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“…15,16 However, data on the possible influence of these factors on cord blood TSH are scarce. Franklin, et al analyzed the effects of maternal diabetes mellitus, toxemia, fetal distress and other factors and concluded that they did not affect cord serum TSH concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Another early report from Fuse, et al also suggested that TSH values in cord blood could be less influenced by perinatal factors than T 4 values. 16 We investigated newborns from mothers affected by severe non-thyroidal diseases, including HIV. Our data confirm that even severe maternal diseases do not affect a screening program using primary TSH from cord blood.…”

Section: Discussionmentioning

confidence: 99%

Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases

2000

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a b s t r a c tCONTEXT: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE:To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. DESIGN:Prospective non-randomized clinical trial with at least 3 months of follow-up. SETTING:A public university referral center [CAISM/Hospital das Clínicas, Faculty of Medicine, University of Campinas, Campinas, SP].PARTICIPANTS: 415 neonates divided into 5 groups: eighty-three infants born from cardiac mothers; 98 from mothers that had toxemia; 54 of the mothers had diabetes mellitus; 40 were HIV positive and 140 had no diseases. INTERVENTION:All newborns had cord blood samples collected on filter paper at birth. MAIN MEASUREMENTS:TSH was measured from dried blood spots using a homemade immunofluorescence assay (sensitivity in dried blood spots = 0.1 mU/L). RESULTS:There was no significant difference in the mean TSH levels among the 5 groups. Moreover, TSH levels were around 5 mU/L in 48% of the newborns, indicating that our region is severely deficient in iodine. CONCLUSIONS:Our results indicate that primary TSH screening programs using cord blood are not affected by maternal diseases. We suggest that, besides its technical advantages over heel punctures with T 4 primary approaches, neonatal screening using primary cord blood TSH may also be used as a monitoring tool for evaluation and control of iodine deficiency disorders (IDD).

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“…However, various factors such as maternal age, gestational age, maternal illnesses during pregnancy, gender of the baby, perinatal insults etc. can influence the CBTSH levels [5,6].…”

Section: Introductionmentioning

confidence: 99%

Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India

Raj

Stephenson

George

et al. 2014

JCDR

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Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives:To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born in a rural tertiary care institution in South India. Methods:A cross-sectional study was done in 430 term neonates at birth to analyse the cord blood TSH levels and a repeat TSH estimation was done on 3 rd postnatal day for those having abnormal values. The values were statistically analysed with respect to maternal, paternal and perinatal parameters.

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Influence of Perinatal Factors and Sampling Methods on TSH and Thyroid Hormone Levels in Cord Blood.

Cited by 33 publications

References 9 publications

A Study of Effect of Perinatal Asphyxia on Thyroid Hormone in Neonates

A Study of Effect of Perinatal Asphyxia on Thyroid Hormone in Neonates

Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases

Cord Blood TSH Level Variations in Newborn – Experience from A Rural Centre in Southern India

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