Background: Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. Objectives:To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born in a rural tertiary care institution in South India. Methods:A cross-sectional study was done in 430 term neonates at birth to analyse the cord blood TSH levels and a repeat TSH estimation was done on 3 rd postnatal day for those having abnormal values. The values were statistically analysed with respect to maternal, paternal and perinatal parameters.

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