A Study of Effect of Perinatal Asphyxia on Thyroid Hormone in Neonates

Abstract

AIMS AND OBJECTIVE:To study the effect of perinatal asphyxia on thyroid hormones of term neonates. MATERIAL AND METHODS: It was a prospective case control study and it was conducted in department of pediatrics, Kamala Nehru Hospital Gandhi Medical College, Bhopal. Total 60 full term neonates who have completed 37 wks of gestation at birth included in study, 30 asphyxiated newborn taken as cases and 30 healthy neonates as control. For inclusion of cases criteria was, 1 and 5 minute APGAR score <7 and Control were selected with criteria of 1-minute APGAR score >7 and no sepsis setting. Classification of HIE done on the bases of Sarnat and Sarnat staging. Blood samples were collected for determination of thyroid profile (T4, T3 and TSH), first within 6 hours of birth and seconds 18 to 24hour of age. RESULT: Out of 30 cases, 13.13% were HIE-I, 50% were HIE-II and 36.67% were HIE-III. Mean value of TSH was low at 6 hours as well as at 18-24 hours between case and control group while mean value of T3 andT4 were low at only 18-24hrs of age. CONCLUSION: The mean T3, T4 and TSH levels at birth of asphyxiated newborn was significantly lower than the control group at 18-24 hours. Due to low TSH surge, asphyxiated babies could not increase their T3 and T4 level significantly.

Study of Impact of Birth Asphyxia on Thyroid Hormone in Newborn.

“…All three mean average values were found to be significantly lower among asphyxiated term newborns than among healthy term newborns. This finding is in line with the study conducted by Tikkas R. et al [8] However, studies conducted by Kim EY. et al and Borges M. et al found a contradictory picture of TSH levels in asphyxiated neonates.…”

“…Therefore, the current study has attempted to examine the impact of birth asphyxia on a newborn's thyroid hormone levels and to determine the relationship between those levels and the severity as well as morbidity related to asphyxia. [8] In the current research, asphyxiated newborns had a mean average weight of 2.80 kg compared to 2.84 kg in the control group. According to research conducted by Borges M. et al; Tahivoric HF.…”

“…[9,10,11] This difference between our research findings and the findings of other studies about the mean average birth weight may be related to ethnic and geographic heterogeneity. [6,8] Our study has also found a positive correlation between the elevation of asphyxia and the mode of delivery of newborn (P = 0.014) and Meconium stained liquor (MSL) (P <0.001).…”