Influence of particle properties on the wall region in packed capillaries

Computational investigation of longitudinal diffusion, eddy dispersion, and trans-particle mass transfer in bulk, random packings of core–shell particles with varied shell thickness and shell diffusion coefficient

“…However, the difference between the contributions of h eddy at different -values to the overall reduced plate height h in the vicinity of the h-minima is marginal. This supports a conclusion from the morphological analysis of the near-wall region in core-shell packings [26], i.e., the reduced eddy dispersion contribution should be basically attributed to a higher transcolumn homogeneity rather than improved bed morphology on smaller length scales.…”

“…(2)) compared to those in columns packed with conventional fully porous particles [4,24]. Later, numerical simulations of hydrodynamic dispersion in bulk random packings of polydisperse particles [25] and the morphological analysis of physically reconstructed packed beds [26] revealed that the smaller eddy dispersion contribution to band broadening in columns packed with core-shell particles should be attributed to a higher transcolumn homogeneity rather than an improved bed morphology on smaller length scales. The origin for the decrease of B and H long terms can be explained by a reduction of the total packed-bed volume accessible for diffusion due to the presence of the particles' solid cores.…”

Core–Shell, Ultrasmall Particles, Monoliths, and Other Support Materials in High-Performance Liquid Chromatography

“…Different results concerning slurry concentration were obtained with smaller i.d capillaries. Performance was impressive for these larger diameter capillaries, which showed h min as low as 1.6, although even better performance was obtained with the narrower i.d column (h min as low as 1.2) 48 . The authors stated that more work was necessary to rationalise these results and extend the finding to interpreting the performance of conventional diameter columns.…”

“…Other work indicated that the smaller A term in shell columns was mainly due to a higher transcolumn homogeneity rather than an improved bed morphology on smaller length scales 48,49 .…”

1.1 μm Superficially porous particles for liquid chromatography

“…region [7]. While this effect is predicted to be less significant for superficially porous particles due to the observation of a denser wall region and a more uniform bed structure than totally porous particles, variations are still expected [8].…”