Influence of paeonol on expression of COX-2 and p27 in HT-29 cells

Ye, Junmei; Deng, Tao; Zhang, Jianbao

doi:10.3748/wjg.15.4410

Cited by 16 publications

(12 citation statements)

References 7 publications

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“…37,38 In human colon cancer LoVo cells, paeonol blocked cell cycle at the G1 to S transition and induced apoptosis. 39 In HT-29 cells, paeonol inhibited proliferation 40 and showed a synergetic antiproliferative effect when combined with 5-FU. 41 In human esophageal adenocarcinoma cells, paeonol showed a dose-dependent growth-inhibitory effect, and this effect was synergistic when combined with cisplatin.…”

Section: Actions Of Paeonia (Chi Shao)mentioning

confidence: 99%

Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer

et al. 2015

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This meta-analysis evaluates the clinical evidence for the addition of traditional medicines (TMs) to oxaliplatin-based regimens for colorectal cancer (CRC) in terms of tumor response rate (TRR). Eight electronic databases were searched for randomized controlled trials of oxaliplatin-based chemotherapy combined with TMs compared to the same oxaliplatin-based regimen. Data on TRR from 42 randomized controlled trials were analyzed using Review Manager 5.1. Studies were conducted in China or Japan. Publication bias was not evident. The meta-analyses suggest that the combination of the TMs with oxaliplatin-based regimens increased TRR in the palliative treatment of CRC (risk ratio [RR] 1.31 [1.20-1.42], I(2) = 0%). Benefits were evident for both injection products (RR 1.36 [1.18-1.57], I(2) = 0%) and orally administered TMs (RR 1.27 [1.15-1.41], I(2) = 0%). Further sensitivity analysis of specific plant-based TMs found that Paeonia, Curcuma, and Sophora produced consistently higher contributions to the RR results. Compounds in each of these TMs have shown growth-inhibitory effects in CRC cell-line studies. Specific combinations of TMs appeared to produce higher contributions to TRR than the TMs individually. Notable among these was the combination of Hedyotis, Astragalus, and Scutellaria.

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Section: Actions Of Paeonia (Chi Shao)mentioning

confidence: 99%

Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer

et al. 2015

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“…3). Additionally, our previous study showed that paeonol regulated the expression of Fas, Bcl-2, Bax and p53, leading to the induction of apoptosis (14). These results indicated that paeonol may inhibit the proliferation of cultured LoVo cells by activating the apoptotic signaling pathway.…”

Section: Discussionmentioning

confidence: 80%

“…Previous studies have revealed that paeonol exhibits antiproliferative effects and apoptosis-inducing activities in various tumor cell lines in vitro and in vivo (9)(10)(11)(12)(13). Our previous study demonstrated that paeonol exhibited antineoplastic activity by promoting apoptosis in the human colorectal carcinoma cell line, HT-29 (14). However, the underlying mechanisms remain unknown.…”

Section: Introductionmentioning

confidence: 97%

Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells

Sheng

Zhang

et al. 2013

Molecular Medicine Reports

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Paeonol, a major phenolic component of the root bark of Paeonia moutan, is known to exhibit antitumor effects. However, the underlying mechanisms remain unknown. In the present study, the effects of paeonol on cell viability, intracellular calcium concentration and the expression of runt‑related transcription factor 3 (RUNX3) were analyzed in LoVo human colon cancer cells. Results revealed that paeonol markedly reduced LoVo cell viability in a time‑ and dose‑dependent manner. Flow cytometry assays demonstrated that paeonol blocked the cell cycle at the G1 to S transition and significantly induced apoptosis in LoVo cells. Intracellular calcium accumulation occurred following a 48 h treatment with paeonol. Furthermore, RUNX3 gene expression was increased in paeonol‑treated cells. These observations indicate that paeonol possesses antiproliferative properties and apoptosis‑inducing activity. One of the antitumor mechanisms of paeonol may be its apoptosis‑inducing activity through an increased intracellular calcium concentration and the upregulation of RUNX3 expression. Paeonol may be a promising antitumor agent for colon carcinoma treatment.

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“…Five randomly selected fields from each section were examined at a magnification of 200x and analyzed with Image-Pro Plus 6.0. The positive content (PC) was calculated as (PC) = mean optical density × positive area[ 24 ].…”

Section: Methodsmentioning

confidence: 99%

SHYCD induces APE1/Ref-1 subcellular localization to regulate the p53-apoptosis signaling pathway in the prevention and treatment of acute on chronic liver failure

Diao

Huang

et al. 2017

Oncotarget

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Background & Aims: San huang yin chi decoction(SHYCD) is derived from the yin chen hao decoction, a well-known and canonical Chinese medicine formula from the “Treatise on Febrile Diseases”. Over the past decade, SHYCD has been used to treat and prevent the liver cirrhosis and liver failure. In the present study, we investigated the effects of SHYCD for acute on chronic liver failure(ACLF) and explored its potential mechanism. an ACLF rat model, which induced by carbon tetrachloride (CCl4) combined with D-galactosamine (D-GalN) and lipopolysaccharide(LPS), was used and confirmed by B-ultrasound analysis. Rats were randomly divided into control group, model group, SHYCD-H group, SHYCD-M group, SHYCD-L group, AGNHW group. Compared with the ACLF model group, High, medium, and low doses of SHYCD reduced ALT, AST, TBIL, NH3, IL-1β, IL-6, and TNFα expression levels in the serum, Shorten PT and INR time,and increased Fbg content in the whole blood, increased survival rate of the rats, improved liver pathological changes. APE1 / Ref-1 was mainly expressed in the nucleus, but the nucleus and cytoplasm were co-expressed after hepatocyte injury. SHYCD significantly downregulated APE1/Ref-1 expression in the cytoplasm. Increased APE1/Ref-1, Bcl-2, reduced p53, caspase-3, Bax, and Cyt-c in the total protein. Base on the results, we conclused that High, medium, and low doses of SHYCD could be applied in prevention and treatment of ACLF, and dose-dependent. The possible mechanism is to promote the APE1 / Ref-1 from the cytoplasm to the nuclear transfer, regulation of p53 apoptosis signal pathway prevention and treatment of ACLF.

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Influence of paeonol on expression of COX-2 and p27 in HT-29 cells

Cited by 16 publications

References 7 publications

Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer

Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer

Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells

SHYCD induces APE1/Ref-1 subcellular localization to regulate the p53-apoptosis signaling pathway in the prevention and treatment of acute on chronic liver failure

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