Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer

Chen, Menghua; May, Brian H.; Zhou, Iris W.; Xue, Charlie Changli; Zhang, Anthony Lin

doi:10.1177/1534735415596424

Cited by 26 publications

(15 citation statements)

References 61 publications

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“…On the other hand, compelling evidence suggests the usefulness of Astragali radix in cancer treatment. Astragalus is included among the specific plants that contribute to tumor response when combined with oxaliplatin-based chemotherapy for colorectal cancer 17 . The combination of Chinese herbal medicine, including Astragali radix, improved the effectiveness of FOLFOX against advanced colon cancer in terms of tumor response rate and one-year survival.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

Mannelli¹,

Pacini

Micheli³

et al. 2017

Sci Rep

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Neurotoxicity is a major side effect of platinum derivatives both during and after treatment. In the absence of effective pharmacological compounds, the opportunity to identify safe adjuvant treatments among medicinal plants seems appropriate. Astragali radix is an adaptogenic herbal product recently analyzed in platinum-treated cancer patients. With the aim of evaluating the anti-neuropathic profile of Astragali radix, a previously characterized aqueous (Aqu) and two hydroalcoholic (20%HA and 50%HA) extracts were tested in a rat model of oxaliplatin-induced neuropathy. Repeated administrations significantly reduced oxaliplatin-dependent hypersensitivity with 50%HA, the most effective, fully preventing mechanical and thermal hypersensitivity. Ex vivo, 50%HA reduced morphometric and molecular alterations induced by oxaliplatin in peripheral nerve and dorsal-root-ganglia. In the spinal cord and in brain areas, 50%HA significantly decreased activation of microglia and astrocytes. Furthermore, 50%HA prevented the nephro- and hepato-toxicity induced by the anticancer drug. The protective effect of 50%HA did not alter oxaliplatin-induced apoptosis in colon tumors of Pirc rats, an Apc-driven model of colon carcinogenesis. The hydroalcoholic extract (50%HA) of Astragali radix relieves pain and promotes the rescue mechanisms that protect nervous tissue from the damages triggering chronic pain. A safe profile strongly suggests the usefulness of this natural product in oxaliplatin-induced neuropathy.

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Section: Discussionmentioning

confidence: 99%

“…It has been prescribed for centuries for general debility, chronic illnesses, and to increase the overall vitality of the system 14 . Current evidence about the combination of Astragalus extracts and chemotherapy (in particular with the FOLFOX regimen) highlight a significant improvement in the patient’s quality of life 15 16 17 18 .…”

mentioning

confidence: 99%

RETRACTED ARTICLE: Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

Mannelli¹,

Pacini

Micheli³

et al. 2017

Sci Rep

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“…Herbal remedies, medicinal plants, and their ingredients are among the agents employed to fight cancer. Today, numerous researchers around the world are investigating the effects of these plant ingredients on cancer cells (32,33). One of these plant ingredients is quercetin which is a flavonoid with proven anticancer properties (34,35).…”

Section: Resultsmentioning

confidence: 99%

The Effects of Quercetin on the Gene Expression of Arginine Metabolism Key Enzymes in Human Embryonic Kidney 293 Cells

Jamehdor

Farivar

Sangtarash

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Arginine metabolism is an important factor involved in tumorigenesis, progression, and survival of tumor cells. Besides, other metabolites produced in the arginine metabolism process, such as polyamines, nitric oxide, argininosuccinate, and agmatine, play key roles in different stages of tumor development. On the other hand, herbal metabolites are widely used to treat cancer. One of these herbal flavonoids is quercetin. Methods: In this study, according to MTT assay data, two concentrations of quercetin flavonoid were selected (57.5 and 115 µM) to treat human embryonic kidney 293 (HEK293) cells. Then RNA was extracted from the cells and used as a template for cDNA synthesis. Using real-time PCR, the expression of key enzymes involved in arginine metabolism was evaluated, including arginase 2 (Arg2), ornithine carbamoyl transferase (OTC), agmatinase (AGMAT), arginase 1 (Arg1), nitric oxide synthase 1 (nNOS), arginine decarboxylase (ADC), ornithine decarboxylase 1 (ODC), ornithine carbamoyl transferase (OCT), spermidine synthase (SRM), spermine synthase (SMS), argininosuccinate synthase 1 (ASS1), and argininosuccinate lyase (ASL). The Student t-test was used to analyze the data considering a P value of < 0.05 as the significance level. Results: Our results indicated significant changes in the expression of arginine metabolism enzymes after quercetin exposure, confirming a role for quercetin plant flavonoid in regulating arginine metabolism in HEK293 cells. Conclusions: Quercetin could alter the gene expression of the key enzymes involved in arginine metabolism. This was the first study investigating the effects of quercetin on arginine metabolism in HEK293 cells.

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“…On the one hand, pre-clinical studies have demonstrated that a number of herbal medicines could increase the sensitivity of cancer cells to chemotherapy drugs, improve survival rates, enhance the tumor response to chemotherapy, and reduce the toxicity of chemotherapy, for example the case of Curcuma longa in colon cancer patients [ 48 ].…”

Section: Evidence Of Effectiveness and Use In Cancer Care: Acupuncmentioning

confidence: 99%

Add-On Complementary Medicine in Cancer Care: Evidence in Literature and Experiences of Integration

et al. 2017

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Background: According to the literature an increasing number of cancer patients demand for complementary therapies during their disease. Research has demonstrated that some of these therapies are effective and safe as adjunctive treatments in specific symptoms of these patients. Methods: The aims of the paper are to review the main and recent papers of international literature on the effectiveness of complementary medicine (CM) therapies on side effects of anti-cancer protocols and improvement in the quality of life of oncological patients, and to describe the integration of evidence-based acupuncture, herbal medicine and homeopathy treatments in Public Cancer Network of the region of Tuscany. Results: After the review of literature and the approval of a Regional Resolution, some CM will be introduced in Cancer Departments in Tuscany to additionally treat cancer-related symptoms and side effects of conventional cancer therapy: acupuncture for nausea and post-chemotherapy and post-surgery vomiting, pain, hot flashes of iatrogenic menopause, xerostomia; homeopathy for hot flashes of iatrogenic menopause and the side effects of radiotherapy; herbal medicine for cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety, and depression. Conclusions: The integration of evidence-based complementary treatments allows for an effective response to the demand coming from cancer patients and combines safety and equity of access in public health systems.

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Meta-Analysis of Oxaliplatin-Based Chemotherapy Combined With Traditional Medicines for Colorectal Cancer

Cited by 26 publications

References 61 publications

RETRACTED ARTICLE: Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

RETRACTED ARTICLE: Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

The Effects of Quercetin on the Gene Expression of Arginine Metabolism Key Enzymes in Human Embryonic Kidney 293 Cells

Add-On Complementary Medicine in Cancer Care: Evidence in Literature and Experiences of Integration

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