Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC

Teeranachaideekul, Veerawat; Boonme, Prapaporn; Souto, Eliana B.; Müller, Rainer H.; Junyaprasert, Varaporn Buraphacheep

doi:10.1016/j.jconrel.2008.02.011

Cited by 187 publications

(113 citation statements)

References 32 publications

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“…The size of the nanoparticles decreased abruptly when the content of liquid lipid exceeded 20 wt% probably due to the expulsion of the excess of liquid lipid during the lipid crystallisation process. In another report, particle size of NLC containing medium chain triglyceride as liquid lipid and produced by hot high pressure homogenisation did not depend on the content of liquid lipid loading (Teeranachaideekul et al, 2007(Teeranachaideekul et al, , 2008. Differences in the results of various studies may be attributed to the difference in the composition of NLC, and the method of production used (Saupe et al, 2006;Lin et al, 2007).…”

Section: Physicochemical Characterisation Of Sln Nlc and Nementioning

confidence: 93%

“…and 48 hr. The occlusion factor depends upon the sample volume, particle size, crystallinity, lipid concentration and type of colloidal systems (Wissing and Muller, 2003;Teeranachaideekul et al, 2008). As the occlusion factor is directly related to the crystallinity of the lipid matrix, the higher crystallinity of SLN explains its higher occlusivity compared to NLC and NE.…”

Section: Occlusion Testmentioning

confidence: 99%

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Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

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This study was aimed to develop nanostructured lipid carriers (NLC) for the possible delivery of mefenamic acid. This study describes the effect of liquid lipid concentration on the characteristics of NLC such as particle size, polydispersity index, zeta potential, drug entrapment efficiency, and occlusivity index. Transmission electron microscopy revealed nearly spherical shape NLC with negligible effect of liquid lipid content on the particle morphology. The differential scanning calorimetry demonstrated a depression in the melting point and crystallinity index of the NLC with an increase in the amount of liquid lipid. The in vitro drug release studies demonstrated that solid lipid nanoparticle (0% oil), and NLC possessed a biphasic release pattern characterised by a rapid initial release followed by a sustained release, in comparison to nanoemulsions (100% oil) of which a nearly constant release was observed. Compared to NE and SLN, the excellent physical stability of NLC against drug leakage was seen.

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Section: Physicochemical Characterisation Of Sln Nlc and Nementioning

confidence: 93%

Section: Occlusion Testmentioning

confidence: 99%

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

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“…Occlusifity led to skin hydration. The hydration of the stratum corneum can affect the rate of penetration of the skin [15][16][17]. The overview of in vivo penetration coenzyme Q10 nanostructured lipid carrier in the abdominal skin of Wistar rat with fluorescent microscopy can be seen in Fig.…”

Section: Coenzyme Q10 Entrapment Efficiencymentioning

confidence: 99%

EFFECTIVITY AND PHYSICOCHEMICAL STABILITY OF NANOSTRUCTURED LIPID CARRIER COENZYME Q10 IN DIFFERENT RATIO of LIPID ALFA CETYL PALMITATE AND ALPHA TOCOPHERYL ACETATE AS CARRIER

Putranti

Hendradi²,

Primaharinastiti³

2017

Asian J Pharm Clin Res

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Objective: The aim of this study was to investigate physical characteristics of nanostructured lipid carriers (NLCs) mixture of alpha tocopheryl acetate, cetyl palmitate, Tween 80 and propylene glycol using high shear homogenization technique on NLC preparation to predict the optimum ratio of alpha tocopheryl acetate-cetyl palmitate to produce good characteristics of NLC loaded coenzyme, higher % EE, good penetration, controlled release, and stable.Methods: Lipid characterizations were conducted by diffraction scanning calorimetry, X-ray diffraction, and Fourier transforms infrared spectrophotometry. Coenzyme Q10 concentration was measured by spectrophotometer at 275 nm. NLC characteristics based on their morphology was determined using transmission electron microscope, particle size, and its polydispersity index which were measured with Delsa Nano™ particle size analyzer. Percentage of coenzyme Q10 entrapped in NLC was determined by dialysis bag method. Coenzyme Q10 release profile was measured using with Franz cell for 12 hrs. The penetration depth of NLC coenzyme Q10 in abdominal skin of Wistar rat was determined with fluorescence microscopy using rhodamine B as marker. NLC physical stability based on minimum of particle size variation, pH and viscosity during 90 days storage. Results:The result showed that formula with ratio of cetyl palmitate-alpha tocopheryl acetate 70:30 (% w/w) produce good characteristics of NLC loaded coenzyme, higher % EE, good penetration, controlled release, and stable in 90 days storage. Conclusion:The coenzyme Q10 NLC system with cetyl palmitate and alpha tocopherol acetate as lipid matrixare characterized by small particle size, low crystallinity, spherical morphology of particle and high coenzyme Q10 entrapment efficiency. Crystal modification led to the formation of a more amorphous thereby increasing the drug entrapment

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“…The loss of water content from the SLN induces crystal modification of SLN matrix and this can induce drug expulsion and penetration [Lombardi Borgia et al 2005]. The occlusion effect of these nanoparticles is dependent on the applied sample volume, particle size, crystallinity and lipid concentration [Teeranachaideekul et al 2008]. The space filled with air in a layer of optimal packing density is independent on the particle size, which is considered to be 24% if assuming a three-dimensional hexagonal packing of ideal spherical-like particles [Desai et al 2010].…”

Section: Skin As a Site For Particle Deliverymentioning

confidence: 99%

Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

Bleve¹,

Pavanetto²,

Perugini³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

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Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC

Cited by 187 publications

References 32 publications

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

EFFECTIVITY AND PHYSICOCHEMICAL STABILITY OF NANOSTRUCTURED LIPID CARRIER COENZYME Q10 IN DIFFERENT RATIO of LIPID ALFA CETYL PALMITATE AND ALPHA TOCOPHERYL ACETATE AS CARRIER

Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

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