Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Abstract

This study was aimed to develop nanostructured lipid carriers (NLC) for the possible delivery of mefenamic acid. This study describes the effect of liquid lipid concentration on the characteristics of NLC such as particle size, polydispersity index, zeta potential, drug entrapment efficiency, and occlusivity index. Transmission electron microscopy revealed nearly spherical shape NLC with negligible effect of liquid lipid content on the particle morphology. The differential scanning calorimetry demonstrated a depression in the melting point and crystallinity index of the NLC with an increase in the amount of liquid lipid. The in vitro drug release studies demonstrated that solid lipid nanoparticle (0% oil), and NLC possessed a biphasic release pattern characterised by a rapid initial release followed by a sustained release, in comparison to nanoemulsions (100% oil) of which a nearly constant release was observed. Compared to NE and SLN, the excellent physical stability of NLC against drug leakage was seen.

Physical, Chemical Characteristics and Release Rate of Meloxicam From Nanostructured Lipid Carriers (Nlc) System Using Some Concentration Ratios of Monostearin and Alpha Tocopherol Acetate Lipid Matrix

“…F1 had the highest percentage of entrapment efficiency, and F6 had the lowest percentage of entrapment efficiency. This result is consistent with the concentration theory of liquid lipid which can produce the big entrapment efficiency, because of the active substance solubility in liquid lipid increases [8].…”

“…A trend toward the decrease in particle size with the increase in content was observed [8]. This is possible because the lipid matrix of different components with different characteristics may give different results.…”

“…The concentration of drug was determined by double-beam ultraviolet (UV)-vis spectrophotometer (Shimadzu UV-1800) with multiple wavelength methods [8].…”

“…Entrapment efficiency increases by increasing the concentration of liquid lipid. In NLC system, high solubility of active ingredient in liquid lipid plays an important role in increasing the entrapment efficiency of active ingredient [8].…”

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

“…NLC kept its stability at 25°C and exhibited only a few degrees of size instability at 40°C, while SLN showed size instability at both 25°C and 40°C. 48 Lidocaine is an efficient rapid onset, intermediate action, and low systemic toxicity local anaesthetic agent. For effective topical delivery, lidocaeine was incorporated into SLN and NLC particles.…”