Influence of Nutritional Status on the Resumption of Adequate Food Intake in Patients Recovering from Colorectal Cancer Operations

Meguid, Michael M.; Mughal, Muntzer; Debonis, Daniel; Meguid, Victoria; Terz, José J.

doi:10.1016/s0039-6109(16)44080-6

Cited by 48 publications

(11 citation statements)

References 17 publications

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“…Therefore the development of noninvasive and sensitive index that can accurately evaluate the prognosis of GC would be beneficial, among them, immune and nutritional status of patients have been reported to predict postoperative complications, recurrence, and prognosis. [ 9 – 12 ] Related studies have shown that the presence of malnutrition and systematic inflammatory response can cause shorter survival and higher possible complications in patients with malignancy. [ 13 , 14 ] The indexes of systemic inflammatory and nutritional scores include neutrophil-lymphocyte ratio (NLR), [ 15 , 16 ] platelet-lymphocyte ratio (PLR), [ 17 , 18 ] prognostic nutritional index (PNI), [ 19 , 20 ] body mass index (BMI), [ 21 ] hemoglobin, [ 22 ] albumin, [ 23 – 25 ] and prealbumin, [ 26 , 27 ] and they can get easily and conveniently before surgery.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type II/III adenocarcinoma of esophagogastric junction

Zhang

Chen

et al. 2017

Medicine

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Background:Immune and nutritional status of patients have been reported to predict postoperative complications, recurrence, and prognosis of patients with cancer. Therefore, this retrospective study aimed to explore the prognostic value of preoperative inflammation-based prognostic scores [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] and nutritional status [prognostic nutritional index (PNI), body mass index (BMI), hemoglobin, albumin, and prealbumin] for overall survival (OS) in adenocarcinoma of esophagogastric junction (AEG) patients.Methods:A total of 355 patients diagnosed with Siewert type II/III AEG and underwent surgery between October 2010 and December 2011 were followed up until October 2016. Receiver operating characteristic (ROC) curve analysis was used to determine the cutoff values of NLR, PLR, and PNI. Kaplan–Meier curves and Cox regression analyses were used to calculate the OS characteristics.Results:The ideal cutoff values for predicting OS were 3.5 for NLR, 171 for PLR, and 51.3 for PNI according to the ROC curve. The patients with hemoglobin <120 g/L (P = .001), prealbumin <180 mg/L (P = .000), PNI <51.3 (P = .010), NLR >3.5 (P = .000), PLR >171 (P = .006), and low BMI group (P = .000) had shorter OS. And multivariate survival analysis using the Cox proportional hazards model showed that the tumor-node-metastasis stage, BMI, NLR, and prealbumin levels were independent risk factors for the OS.Conclusion:Our study demonstrated that preoperative prealbumin, BMI, and NLR were independent prognostic factors of AEG patients.

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Section: Introductionmentioning

confidence: 99%

The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type II/III adenocarcinoma of esophagogastric junction

Zhang

Chen

et al. 2017

Medicine

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“…Malnutrition is defined as a nutritional status in which a deficiency in energy, protein, or other nutrients causes measurable adverse effects on tissue or body form, function and clinical outcome [6,7]. It is associated with poorer overall survival in various malignancies [2,7,8,9], as well as reduced benefit from surgical [10,11,12] and medical treatments [13], a poorer tumor response to chemotherapy [2,8,13], and increased chemotherapy-related toxicity [14,15,16]. As suggested by Cessot et al [17], nutritional status could be as accurate as performance status to identify patients at risk for increased chemotherapy-related toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…QoL is also a major concern at present. Several studies have shown a negative impact of malnutrition on postoperative outcome of patients with resectable CRC [11,26,27,28], but the prognostic significance of the nutritional status in mCRC patients treated with modern chemotherapy regimens is largely unknown [22,29]. …”

Section: Introductionmentioning

confidence: 99%

Nutritional Status Affects Treatment Tolerability and Survival in Metastatic Colorectal Cancer Patients: Results of an AGEO Prospective Multicenter Study

et al. 2011

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Background: The possible impact of malnutrition on the tolerability and efficacy of modern chemotherapy regimens for metastatic colorectal cancer (mCRC) is unclear. Methods: In this prospective, cross-sectional, multicenter study, we collected demographic, oncological and nutritional data for all consecutive mCRC patients during a 14-day period in eight hospitals. Nutritional status was assessed with the nutritional risk index (NRI), and patients were classified as severely malnourished when NRI was <83.5; drug-induced toxicities were evaluated using the National Cancer Institute Common Toxicity Criteria (version 3.0). Survival times were calculated from the date of the nutritional assessment. Results: We enrolled 114 mCRC patients (median age: 65 years, range: 22–92; WHO performance status 0/1/2/3: 21/54/21/4%) of whom 88% had at least 2 metastatic sites and 49% were receiving chemotherapy as first-line treatment. Malnutrition was diagnosed in 65% of the patients and was severe in 19%. Severe malnutrition was associated with more adverse effects following chemotherapy (p = 0.01) and with shorter median overall survival (14.0 vs. 36.2 months in non-/moderately malnourished patients, p = 0.02). Conclusions: In mCRC patients, severe malnutrition is associated with greater chemotherapy toxicity and reduced overall survival.

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“…The association between preoperative nutritional status and the outcomes of surgical interventions has been considerably researched (37,38). Based on the results of such studies, a poor preoperative nutritional status was considered to correlate with the incidence of postoperative complications.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Nutritional Assessment Using the Controlling Nutritional Status Score to Predict Pancreatic Fistula After Pancreaticoduodenectomy

Utsumi

Aoki

Nagahisa

et al. 2020

In Vivo

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Backgound: This study aimed to determine the usefulness of the Controlling Nutritional Status (CONUT) scorescore for predicting postoperative pancreatic fistula (POPF). Patients and Methods: Data from 108 consecutive pancreaticoduodenectomy cases performed at the Surgery Department of Iwakuni Clinical Center, from April 2008 to May 2018, were included. Preoperative patient data and postoperative complication data were collected. Results: Of the 108 patients (male=65; female=43; mean age=70 years), 41 (37.9%) had indication for pancreaticoduodenectomy due to pancreatic carcinoma. Grade B or higher POPF was diagnosed in 32 patients (29.6%). In the multivariate analysis, body mass index ≥22 kg/m 2 [odds ratio (OR)=5.24; p=0.005], CONUT score ≥4 (OR=3.28; p=0.042), nonpancreatic carcinoma (OR=47.17; p=0.001), and a low computed tomographic contrast attenuation value (late/early ratio) (OR=4.39; p=0.029) were independent risk factors for POPF. Conclusion: Patients with high CONUT score are at high risk for POPF. Preoperative nutritional intervention such as immunonutrition might help reduce the POPF risk in these patients.

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Influence of Nutritional Status on the Resumption of Adequate Food Intake in Patients Recovering from Colorectal Cancer Operations

Cited by 48 publications

References 17 publications

The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type II/III adenocarcinoma of esophagogastric junction

The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type II/III adenocarcinoma of esophagogastric junction

Nutritional Status Affects Treatment Tolerability and Survival in Metastatic Colorectal Cancer Patients: Results of an AGEO Prospective Multicenter Study

Preoperative Nutritional Assessment Using the Controlling Nutritional Status Score to Predict Pancreatic Fistula After Pancreaticoduodenectomy

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