Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

Stevanović, Nikola; Mijatović, Aleksandar; Lolić, Aleksandar; Zlatović, Mario; Baošić, Rada

doi:10.1007/s11696-021-01884-5

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thanks to the existence of similarities between intermolecular interactions that determine the behavior of compounds in biological and chromatographic environments, chromatographic parameters are applied as alternative measures of lipophilicity of compounds [6][7][8][9][10][11]. In addition, recent research has confirmed the possibility of applying chromatographic parameters in the assessment of pharmacokinetic and toxic properties of new compounds [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

QSRR Descriptors as a Tool in the Study of the Barbituric Acid Derivatives’ Biological Profile

Apostolov

Stojiljković

Vaštag

2022

View full text Add to dashboard Cite

Thanks to the in silico approach in drug design, the identification of new molecules is enabled and facilitated, as well as the optimization of the pharmacokinetics and toxicity of compounds obtained from different sources. Chromatographic methods, on the other hand, provide accurate and reliable information on the influence of the nature of substituents and applied organic modifiers on the pharmacological behavior of compounds, relying on the existence of similarities between intermolecular interactions that determine compound behavior in biological and chromatographic media. Barbituric acid derivatives were subjected to QSRR analysis and the parameters obtained by reversed phase thin layer chromatography (RP TLC18 F254s) were correlated with selected software-derived predictors of permeability, pharmacokinetics and toxicity using the method of linear regression. Тhus satisfactory mathematical models were obtained.

show abstract

Section: Introductionmentioning

confidence: 99%

QSRR Descriptors as a Tool in the Study of the Barbituric Acid Derivatives’ Biological Profile

Apostolov

Stojiljković

Vaštag

2022

View full text Add to dashboard Cite

show abstract

Insights into the lipophilicity of four commonly prescribed antidiabetic drugs and their simultaneous analysis using a simple TLC-spectrodensitometric method: Application to fixed-dose combination tablets and human plasma

Hosny

2022

Journal of Chromatography B

View full text Add to dashboard Cite

Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

Cited by 2 publications

References 35 publications

QSRR Descriptors as a Tool in the Study of the Barbituric Acid Derivatives’ Biological Profile

QSRR Descriptors as a Tool in the Study of the Barbituric Acid Derivatives’ Biological Profile

Insights into the lipophilicity of four commonly prescribed antidiabetic drugs and their simultaneous analysis using a simple TLC-spectrodensitometric method: Application to fixed-dose combination tablets and human plasma

Contact Info

Product

Resources

About