Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial

Karan, Nazife Begüm

doi:10.1016/j.physbeh.2019.112676

Cited by 67 publications

(84 citation statements)

References 37 publications

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“…Lavender is often mentioned as the "mother" of essential oils [3]. One of the components in lavender oil, linalool, was found to have an inhibitory effect on the limbic system and autonomic neurotransmission, which ultimately lead to a drop in blood pressure [7,8], this systemic effect is associated with gamma-aminobutyric acid (GABA-A) receptors, which are known to play an important role in reducing anxiety levels [9]. Lavender oil is known to be one of the most effective essential oils for relieving anxiety disorders, and it is regarded as an accessible and safe option compared with anti-psychotic medications (e.g., alprazolam, lorazepam, and diazepam) [10].…”

Section: Introductionmentioning

confidence: 99%

How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials

Kang

Nam

Lee

et al. 2019

Asian Nursing Research

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Purpose: Although lavender is purported to possess anxiolytic and sedative properties and is often recommended for relieving anxiety, the efficacy of lavender has not been well established. Thus, this review aimed to evaluate the anxiolytic effects of lavender aromatherapy. Methods: Ten data bases were searched for studies published between 2000 and 2018. Randomized controlled trials investigating the anxiolytic effects of lavender aromatherapy with any type of application for persons with or without clinical anxiety were included. The outcome variables included selfrated anxiety, vital signs, and salivary cortisol and chromogranin A (CgA) levels. In the meta-analysis, standardized mean difference and 95% confidence interval were calculated as effect measures by applying the random effect model and inverse variance method. Results: Twenty-two trials met our inclusion criteria. Lavender aromatherapy was found to have favorable effects in relieving anxiety (Hedges'ĝ ¼ À0.65; 95% CI, À0.84 to À0.46) and decreasing systolic blood pressure (ĝ ¼ À0.22; 95% CI, À0.43 to À0.02), heart rate (ĝ ¼ À0.53; 95% CI, À0.74 to À0.32), and salivary cortisol (ĝ ¼ À1.29; 95% CI, À2.23 to À0.35) and CgA (ĝ ¼ À2.29; 95% CI, À3.24 to À1.34) levels. However, the meta-analysis did not reveal any significant effects of lavender on diastolic blood pressure (effect size: À0.17; 95% CI, À0.37e0.04). Conclusion: Aromatherapy using lavender oil might have favorable effects on anxiety and its physiological manifestations. Future studies are recommended with an emphasis on methodological quality. In nursing practice, it is suggested that lavender aromatherapy be included in programs intended to manage anxiety in patients across diverse healthcare settings.

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Section: Introductionmentioning

confidence: 99%

How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials

Kang

Nam

Lee

et al. 2019

Asian Nursing Research

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“…Of the 710 studies identified from the initial search, eleven RCTs (Cao et al., 2016; Deng & Chen, 2017; Hasheminia et al., 2014; Jafarzadeh et al., 2013; Karan, 2019; Kritsidima et al., 2010; Lehrner, Eckersberger, Walla, Potsch, & Deecke, 2000; Premkumar, Syed Aafaque, Sumalatha, & Narendran, 2019; Soni, Bhatia, & Oberoi, 2018; Venkataramana et al., 2016; Zabirunnisa et al., 2014) and six CCTs (Lehrner, Marwinski, Lehr, Johren, & Deecke, 2005; Nardarajah, Dhanraj, & Jain, 2018; Prayitno, Sulistiyani, & Yuwono, 2018; Toet, Smeets, Dijk, Dijkstra, & Reijen, 2010; Wang & Yang, 2014; Yan et al., 2011) met inclusion criteria and were therefore included in this review.…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 summarises the characteristics of the 17 included studies which comprised a total of 2,499 participants. Of the selected studies, 11 studies (Hasheminia et al., 2014; Jafarzadeh et al., 2013; Karan, 2019; Kritsidima et al., 2010; Nardarajah et al., 2018; Prayitno et al, 2018; Premkumar et al., 2019; Soni et al., 2018; Venkataramana et al., 2016; Wang & Yang, 2014; Yan et al., 2011; Zabirunnisa et al., 2014) had specified the allergies as one of the exclusive criteria at study recruitment, and ten studies (Cao et al., 2016; Deng & Chen, 2017; Hasheminia et al., 2014; Jafarzadeh et al., 2013; Kritsidima et al., 2010; Nardarajah et al., 2018; Premkumar et al., 2019; Soni et al., 2018; Wang & Yang, 2014; Yan et al., 2011) had excluded patients with olfactory dysfunctions at study recruitment. It should be noted that two studies (Jafarzadeh et al., 2013; Soni et al., 2018) included child participants only to evaluate the effect of aromatherapy on children's dental anxiety.…”

Section: Resultsmentioning

confidence: 99%

“…The most commonly used aromatherapy method in the included studies was lavender fragrance. Eleven studies comprising 1,874 participants evaluated the effects of lavender aromatherapy on dental anxiety (Cao et al., 2016; Deng & Chen, 2017; Karan, 2019; Kritsidima et al., 2010; Lehrner et al., 2005; Nardarajah et al., 2018; Premkumar et al., 2019; Venkataramana et al., 2016; Wang & Yang, 2014; Yan et al., 2011; Zabirunnisa et al., 2014), six studies (439 participants) evaluated the ambient odour of orange (Hasheminia et al., 2014; Jafarzadeh et al., 2013; Lehrner et al., 2000, 2005; Soni et al., 2018; Toet et al., 2010), one study (138 participants) examined apple scent (Toet et al., 2010), one study (48 participants) examined the use of rose fragrance (Premkumar et al., 2019), and one study (15 participants) examined Cabe Jawa ( Piper retrofraktrum Vahl.) aromatherapy (Prayitno et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of aromatherapy on dental anxiety: A systematic review of randomised and quasi‐randomised controlled trials

Cai

Zhong

et al. 2020

Oral Diseases

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Objectives To evaluate the efficacy of aromatherapy on dental anxiety. Methods A detailed protocol was registered a priori (PROSPERO: CRD42019141093). PubMed, EMBASE, CDSR, CENTRAL, CNKI and grey literature databases were searched from inception to 10 January 2020. Randomised controlled trials (RCTs) and quasi‐randomised controlled trials (CCTs) that examined the effects of aromatherapy on dental anxiety, compare to either negative control (i.e. no aromatherapy) or other positive control approaches (e.g. music), were included. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration's tool and ROBINS‐I, while the certainty of evidence was assessed using GRADE. A narrative synthesis was performed, rather than meta‐analysis, due to the high level of heterogeneity across studies. Results Eleven RCTs and six CCTs were included. The risk of bias was identified as either high or unclear in RCTs, and moderate to serious in CCTs. Performance bias and detection bias were the most prevalent in RCTs, followed by selection bias and reporting bias. As to CCTs, greater risk of bias was found in the selection of participants into the study and in the measurement of outcomes. Based on the selected studies, the most commonly used aromatherapy for dental anxiety management was lavender fragrance, followed by orange. Compared to the negative control condition, aromatherapy might reduce the anxiety‐related physiological parameters and psychometric rating, pain, and mood, alertness, and calmness compared to the negative control condition; and there might be no intergroup difference in such outcomes between aromatherapy and music. However, GRADEs of the relevant evidence were judged as low to very low. Conclusions Compared to the negative control condition, aromatherapy is more effective to reduce dental anxiety and has comparable effects on dental anxiety compared to music intervention; however, the certainty of evidence is relatively limited. Further high‐quality randomised trials with robust study design and large sample size are warranted to confirm our findings and to confirm the role of aromatherapy in relieving dental anxiety.

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“…I am extremely interested in the recent study from Turkey in which children receiving dental care inhale lavender oil three minutes before dental treatment. 2 I have used lavender oil myself as an anxiolytic and relaxant. I would love to be able to use this technique if it is to be proven effective for use in general practice.…”

mentioning

confidence: 99%

'The first challenge in managing anxiety is recognising it'

2020

Br Dent J

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The first challenge in managing anxiety is recognising it' I ntroduction A recent BDJ study showed that playing music during minor oral surgery helped patients feel more at ease: https://www.nature.com/articles/ s41415-019-1162-1. 1 Authors from Turkey have investigated the use of lavender oil in reducing anxiety in dental patients: https://www.ncbi.nlm.nih. gov/pubmed/31505191. 2 This news story published in The Irish News also mentions a study focusing on lavender oil for child dental patients:

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Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial

Cited by 67 publications

References 37 publications

How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials

How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials

Efficacy of aromatherapy on dental anxiety: A systematic review of randomised and quasi‐randomised controlled trials

'The first challenge in managing anxiety is recognising it'

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