How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials

Kang, Huiman; Nam, Eun Sook; Lee, Yongmi; Kim, Myoungsuk

doi:10.1016/j.anr.2019.11.003

Cited by 46 publications

(65 citation statements)

References 36 publications

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“…Of particular interest are the effects of terpenes and terpenoids on the suppression of inflammatory and infection responses and the immunomodulatory properties of these compounds (117). Aromatherapy has been explicitly and/or implicitly part of CIM worldwide, particularly in the field of botanical medicine, where such properties are used to achieve specific therapeutic goals (118)(119)(120), for example to reduce anxiety (121). Due to their anti-microbial portfolio, several of these substances are of interest for the prevention of (respiratory) infections, the supportive treatment of conventional treatments, or a stand-alone CIM therapy in the case of a mild course of respiratory tract infections (122).…”

Section: Aromatherapymentioning

confidence: 99%

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

et al. 2020

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Background: During the COVID-19 pandemic people are facing risks of adverse health effects due to the restrictions implemented such as quarantine measures, reduced social contact, and self-isolation. In this qualitative review, we collected data on potential preventive and therapeutic health benefits of Complementary and Integrative Medicine (CIM) that might be useful during the COVID-19 pandemic. We have reviewed the scientific literature to summarize CIM practices that could be beneficial for improving physical and mental health and well-being of the population under the current pandemic circumstances. It must be noted that this review is not SARS-CoV-2 specific and we explicitly do not intend to make any SARS-CoV-2 specific health claims in this article.Methods and Findings: A qualitative, non-systematic literature review was conducted in Medline to identify literature describing preventive and therapeutic CIM approaches for strengthening mental and physical health. For a variety of CIM approaches clinical evidence was identified, indicating beneficial effects. CIM approaches include specific dietary measures and selected micronutrients, physical activity, techniques from Mind-Body Medicine, single botanicals or botanical compounds, and spending time in nature among others. The effects of CIM measures on conditions like obesity and hypertension are of special relevance here, as these conditions are considered as risk factors for a severe course of COVID-19. Moreover, a possibly direct effect of CIM approaches on immune functions and clinical parameters in respiratory tract infections, such as influenza, were identified. The findings of this review could be helpful for clinicians, patients, and the general population during the current pandemic when discussing and/or considering CIM options.Conclusions: CIM offers a variety of preventive and therapeutic options for strengthening physical and mental resilience, which could also be useful in the current COVID-19 pandemic. The evidence of CIM approaches with a potential benefit in the COVID-19 pandemic in different areas is worth to be analyzed. While this qualitative review has several obvious limitations, it might serve as useful starting point for further research on this topic.

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Section: Aromatherapymentioning

confidence: 99%

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

et al. 2020

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“…The microprogation of L. viridis was performed and in vitro shoot cultures and microprogated plants have also been a target of study [46,64]. In shoot cultures, authors [64] reported that 1,8-cineole (7) and α-pinene (8) were the most important compounds. Camphor (6) was the third most important volatile compound in the in vitro shoots EOs.…”

Section: Lavandula Pedunculata (Miller)mentioning

confidence: 99%

“…When antioxidant and anti-protozoal activities of L. viridis EOs were compared to those of L. luisieri, it was verified that they were less active (Table 1). When different extraction methods were used for obtaining the volatile fractions and EOs, Costa et al [47] verified that hydrodistillation was the best method for obtaining samples with higher antioxidant and anti-acetylcholinesterase activities than the volatile samples obtained by supercritical fluid extraction (7). In vitro anti-fungal activities of L. stoechas subsp.…”

Section: Lavandula Pedunculata (Miller)mentioning

confidence: 99%

“…Since ancient times lavender has been used to perfume bathing water to help purify the body and spirit; and to alleviate insomnia; anxiety; fatigue; meteorism; flatulence; vomiting; loss of appetite; headaches; toothaches; joint pain and sores [5]. These properties have been attributed to its essential oils (EOs), nevertheless some authors in their systematic review and meta-analysis that have focused on the effect of lavender EOs in humans concluded that more attention should be paid in the interpretation of results due to the following factors: heterogeneity between studies, small number of studies and small sample sizes [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Essential oils of spontaneous species of the genus Lavandula from Portugal: a brief review

Vairinhos

Miguel

2020

Zeitschrift Für Naturforschung C

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Spontaneous lavender growing in uncultivated fields in Portugal have been used in traditional medicine for internal and external uses. The essential oils (EOs) of Lavandula stoechas subsp. luisieri are characterized by the presence of trans-α-necrodyl acetate and trans-necrodol. These EOs are able to prevent the generation and deposition of neurotoxic β-amyloid peptide in Alzheimer’s disease. The EOs also present antibacterial, anti-fungal, anti-Leishmania, antioxidant, anti-inflammatory and antifeedant effects. In the case of hydrodistillation, the predominant compound of Lavandula viridis EO was 1,8-cineole, nevertheless in the case of supercritical fluid extraction, the main constituent was camphor. In in vitro shoots EOs, 1,8-cineole and α-pinene were the most important compounds. The EOs presented anti-fungal activity particularly against Cryptococcus neoformans and dermatophytes. The antioxidant and anti-protozoal activities of L. viridis EOs were lower than L. stoechas subsp. luisieri EOs, with hydrodistillation being the best method for obtaining samples with higher antioxidant and anti-acetylcholinesterase activities. The presence of fenchone, 1,8-cineole and camphor was a common trace of the Lavandula pedunculata subsp. pedunculata EOs and in in vitro axillary shoots EOs. Lavandula pedunculata subsp. lusitanica EOs were predominantly constituted of fenchone and camphor. The antioxidant activity of L. pedunculata subsp. lusitanica EOs was poorer than other Lavandula EOs from Portugal.

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“…Lavender has become an increasingly popular alternative due to increased knowledge of its pharmacological effects and significant clinical potential on its own or as adjuvant therapy in different disorders (Koulivand, Khaleghi Ghadiri, & Gorji, 2013). However, due to issues, such as methodological inadequacies, small sample sizes, short duration of lavender application, lack of information regarding dose rationale, variation between efficacy and effectiveness trials, the variability of administration methods, the absence of a placebo comparator, and lack of control groups, more standard experiments and research are needed to confirm the beneficial effect of lavender with neurological disorders (Kang, Nam, Lee, & Kim, 2019;Koulivand et al, 2013). Some research did not define the contents of lavender and several factors, such as temperature, skin type and quality, and the size of area being treated, which may affect the level and rate of lavender absorption after massage or aromatherapy, were not considered (Kang et al, 2019;Koulivand et al, 2013).…”

Section: Lavender Oil Diffusormentioning

confidence: 99%

Patient Safety of Older Adults with Cognitive Impairment: Evaluation of a Service Improvement Initiative

Patel¹

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Background The safety of older adults with cognitive impairment is linked to falls and to aggressive incidents, therefore patient safety is an important aspect of care for this group of older adults. Environmental changes to create a more ‘dementia-friendly’ setting can create a safer space for patient care. The Kings Fund Healing the Healthy Environmental tool was used to make small changes to a ward environment. The changes included; large face clocks, identification of bed spaces, lavender oil diffusor, and viewing gardens, to improve patient safety. Research Objectives -To assess the impact of environmental changes on patient reportable events (falls and aggression) in older persons’ wards, through a comparative analysis of incidents in the wards – one (Ward A) with environmental changes and the other (Ward B) with usual environment. -To obtain staff perspectives of the changes implemented in the service initiative. Method A practice-based impact evaluation using mixed methods was undertaken to evaluate the service initiative. The methods included an analysis of data from an established database that captured reported falls and aggressive behaviour (quantitative data), and a survey of healthcare staff about the effectiveness of environmental changes (qualitative data). Results The results show that the environmental changes implemented through the service initiative reduced the number of reported falls and aggressive incidents in Ward A in the high visible room. Following the environmental change, the rate of falls per 100 nights in Ward A high visible room was 2.43 compared with a rate of 3.23 times in Ward B. The number of aggressive incidents was 10 in Ward A and 9 in Ward B. The survey findings indicated staff valued the environmental changes particularly the large face clocks. Conclusion While the quantitative data results are not statistically significant the results indicate that the environmental changes implemented (large face clocks, identification of bed spaces, lavender oil diffusor, and viewing gardens) led to a lower number of reportable events for falls in Ward A. Any reduction in the numbers of falls and aggressive behaviour is clinically significant given the impact of such events on patient health and length of stay. The dementia-friendly environmental changes implemented were shown to be an effective service initiative. Clinical and research implications Wards that cater for older people with cognitive impairment should consider implementing low-cost environmental changes such as introducing large face clocks, clear identification of bed spaces, lavender oil diffusors, and viewing gardens. Further research using a larger patient population (a longer time frame or several wards) is required to obtain an adequately powered study.

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How Strong is the Evidence for the Anxiolytic Efficacy of Lavender?: Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 46 publications

References 36 publications

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

Essential oils of spontaneous species of the genus Lavandula from Portugal: a brief review

Patient Safety of Older Adults with Cognitive Impairment: Evaluation of a Service Improvement Initiative

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