Influence of Terminalia chebula on dermal wound healing in rats

Abstract

The effects of topical administration of an alcohol extract of the leaves of an evergreen plant, Terminalia chebula, on the healing of rat dermal wounds, in vivo, was assessed. T. chebula treated wounds healed much faster as indicated by improved rates of contraction and a decreased period of epithelialization. Biochemical studies revealed a significant increase in total protein, DNA and collagen contents in the granulation tissues of treated wounds. The levels of hexosamine and uronic acid in these tissues, also increased upto day 8 post-wounding. Reduced lipid peroxide levels in treated wounds, as well as ESR measurement of antioxidant activity by DPPH radical quenching, suggested that T. chebula possessed antioxidant activities. The tensile strength of tissues from extract-treated incision wounds increased by about 40%. In addition, T. chebula possessed antimicrobial activity and was active largely against Staphylococcus aureus and Klebsiella. These results strongly document the beneficial effects of T. chebula in the acceleration of the healing process.

Madecassoside Reduces Ischemia-Reperfusion Injury on Regional Ischemia Induced Heart Infarction in Rat

“…In addition, it has been shown to promote fibroblast proliferation and collagen synthesis and to have antiulcer activity. 4,9,10) In our laboratory, it is found that MA can exert anti-ischemic effect in vitro and protect isolated rat hearts and cardiomyocytes against reperfusion injury. MA also has the protective effect on vascular endothelial cell injury and can raise the coronary flow of isolated rat heart (unpublished).…”

Promotion of Dermal Wound Healing by Polysaccharides Isolated from Phellinus gilvus in rats

“…The healing process can be related to inflammation leading to epithelialization, formation of granulation tissue, and tissue remodeling [9]. Several natural products have been investigated in the promotion of wound healing [17,18]. Among them, Madecassol ® from quantitative extract of Centella asiatica is a well-known commercial ointment for promoting of dermal wound healing.…”

Wound healing activity ofWithania coagulansin streptozotocin-induced diabetic rats

“…Increase in rate of wound contraction might be a result of the enhanced activity of fibroblasts mediated by specialized myofibroblasts found in the granulated tissues (Moulin et al, 2000). Thus, rate of contraction determines the period of epithelialization which can be defined as the centripetal movement of the edges of a full-thickness wound to facilitate closure of the defect (Suguna et al, 2002). The rate of contraction is directly associated with the amount of collagen deposited.…”