Influence of Hydroxypropyl Methylcellulose Molecular Weight Grade on Water Uptake, Erosion and Drug Release Properties of Diclofenac Sodium Matrix Tablets

Âkbari, Jafar; Enayatifard, Reza; Saeedi, Majid; Saghafi, Massoud

doi:10.4314/tjpr.v10i5.1

Cited by 14 publications

(13 citation statements)

References 12 publications

(25 reference statements)

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“…Similar observations have been made by other authors: in media with low ionic strengths, the use of a higher viscosity grade resulted in lower rates of dissolution from the HPMC matrices . The rationale behind is in the greater degree of chain entanglement, that is, more tortuous gel layer, that reduces drug permeation across the matrix what results in slower drug release …”

Section: Resultssupporting

confidence: 84%

Influence of ionic strength and HPMC viscosity grade on drug release and swelling behavior of HPMC matrix tablets

Krese

Kovačić

Kapele

et al. 2016

J of Applied Polymer Sci

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This work is dedicated to the late Prof. Sa sa Baumgartner who did a great piece of research on HPMC-based formulations and their biopharmaceutical characterization.ABSTRACT: Matrix tablets containing paracetamol and hydroxypropyl methylcellulose (HPMC 2906) of different viscosity grades (50, 400, 1500, and 4000 mPaÁs) were evaluated for drug release and change in matrix tablet mass [DM (%)] after exposure to 0.09, 0.15, 0.31, and 0.52M ionic strengths of dissolution media. At 0.09 and 0.15M ionic strength, drug-release profiles reflected the extended release characteristic; in addition the increase in DM was slow and continuous within first few hours. At 0.31M the higher viscosity grade matrices showed extensive initial swelling and the loss of extended release whereas at 0.52M a similar tablet performance is observed for the matrices of all viscosity grades. Notably, when extensive increase in DM occurs in the very beginning of exposure to medium the loss of extended release from the matrix is expected.

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Section: Resultssupporting

confidence: 84%

Influence of ionic strength and HPMC viscosity grade on drug release and swelling behavior of HPMC matrix tablets

Krese

Kovačić

Kapele

et al. 2016

J of Applied Polymer Sci

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“…On the other hand, HPMC 50cp (F2) showed a significant diminution (p<0.05) in D2 min (40.1%) in comparison to F1 (HPMC 15cp) (55.8 %) and F3 (PVA) (60.4%), since HPMC 50cp produces a dense and thick gel formed by a fast and rapid water uptake that retards further hydration by dissolution media which accordingly decreases the drug release [29][30][31].…”

Section: Effect Of Strip Forming Polymer Types On the In Vitro/in Vivmentioning

confidence: 99%

Optimization and Evaluation of Chlorpheniramine Maleate Oral Strip for Pediatric Use

Mahmood

Sabry

Yousif

et al. 2018

Asian J Pharm Clin Res

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Objective:The goal of performing this study is to prepare an oral strip, especially designed for pediatric use that provides fast onset of action with ease of swallowing particularly for young individuals who suffer from difficulty of swallowing, in addition provides maximum therapeutic effectiveness by reducing the first pass effect. Materials and Methods:The oral strip was prepared by solvent casting technique through using different sole polymers (hydroxypropyl methylcellulose [HPMC] 15cp, HPMC 50cp, polyvinyl alcohol, and sodium carboxymethyl cellulose). Maltodextrin (MD) was added as the secondary polymer in different ratios to optimize the release parameters, and disintegration time (DT), three different plasticizers were employed (propylene glycol, dibutyl phthalate, and glycerin) to boost the film forming polymer characteristics.Results: From this study, it is obvious that F10 which composed of HPMC as a main polymer and MD as a secondary polymer in ratio 2:1, respectively, provides adequate physicochemical characteristics, in vitro/in vivo DT DT (40/36 s), respectively, nevertheless a satisfactory release parameters as (59.9%) released at 2 min and 80% of drug released at 14.8 min. Conclusion:The optimized formula is pretty encouraging to originate an oral strip that provides ease of administration, fast onset of action with wide acceptance for the pediatric population.

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“…A higher molecular weight polymer has a greater degree of entanglement and thus will reduce the molecular diffusion area and permeation of the drug across the matrix gel. When the polymer concentration increases, there will be increase in the viscosity of the polymer gel and which thus results in longer diffusional path [77]. This causes a decrease in the diffusion coefficient of the drug and reduction in the release rate of the drug.…”

Section: Effect Of Polymer Concentration On Drug Entrapmentmentioning

confidence: 99%

Study of Effect of Different Factors in Formulation of Micro and Nanospheres with Solvent Evaporation Technique

Subedi¹,

Shrestha²,

Shakya³

2016

PHARMSCI

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Background: There are various methods of formulation of micro and nanospheres such as solvent evaporation, solvent removal, polymerization, hot-melt encapsulation, coacervation, phase/wet inversion, spray drying, spray congealing etc. Amongst these all, solvent evaporation is one of the most widely used, researched, easy, accessible methods and for which many patents have been applied. It is thus imperative to understand the basics of effect of formulation variables and design of solvent evaporation method which will be covered in this review article. Objective: To discuss the various formulation factors while designing the robust micro and nanospherical systems with better morphology, entrapment and release of the drugs. Method: Systematic analysis of the relevant literature, bibliographies, and interactions with investigators. Results: From the investigation of different literatures, it was found that various factors of solvent evaporation technique may be controlled in order to design the micro and nanospheres of suitable morphology, entrapment and release characters. Conclusion: Various factors like type of polymer used, weight, viscosity, hydrophilicity, concentration, polymer ratio, stirring speed, emulsifier concentration, concentration of cross-linking agents, type of solvent used, rate of addition of solvent etc. Affect the yield, morphology, release and entrapment of the drug inside the system. Hence, these factors play crucial role in the design of a robust micro and nanospherical system.

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Influence of Hydroxypropyl Methylcellulose Molecular Weight Grade on Water Uptake, Erosion and Drug Release Properties of Diclofenac Sodium Matrix Tablets

Cited by 14 publications

References 12 publications

Influence of ionic strength and HPMC viscosity grade on drug release and swelling behavior of HPMC matrix tablets

Influence of ionic strength and HPMC viscosity grade on drug release and swelling behavior of HPMC matrix tablets

Optimization and Evaluation of Chlorpheniramine Maleate Oral Strip for Pediatric Use

Study of Effect of Different Factors in Formulation of Micro and Nanospheres with Solvent Evaporation Technique

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