The results of this study showed that T. chebula extract was capable of accelerating wound healing in rats by wound contraction, and had beneficial effects more than SSD 1% cream in the management of burn injury.
Purpose: To develop a oral controlled matrix drug delivery system for a highly water soluble drug, diltiazem HCl, and investigate its drug release mechanism. Method: Diltiazem HCl was chosen because of its high water solubility. Tablets containing the drug were prepared by direct compression method using different matrix ratios of ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC). The formulations were evaluated in vitro for their dissolution characteristics over a period of 8 h. Drug release was analysed according to various release kinetic models. Results: The results showed that these polymers slowed down the release of diltiazem HCl from the matrices. In the presence of EC, increasing the concentration of HPMC decreased the release rate of diltiazem. Furthermore, incorporation of EC in tablets with HPMC as the matrix was found to control drug release. Kinetic analysis showed that drug release from three of the formulations was adequately described by zero order model. Conclusion: The formulations developed could potentially be used for controlled delivery of highly soluble drugs such as diltiazem HCl.
Compared with placebo, cholestyramine ointment (15%) reduced postoperative pain at rest and on defecation, and consequently lowered the analgesic requirement after open hemorrhoidectomy.
(F4, F5 and F6) showed higher water uptake than those containing the lower molecular weight polymer (F1, F2 and F3) (p < 0. 001). The formulations incorporating the lower molecular weight HPMC K4M (F1, F2 and F3) showed higher erosion than those that contained HPMC K15M (F4, F5 and F6) (p < 0.001
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