Influence of HLA-G polymorphisms in human immunodeficiency virus infection and hepatitis C virus co-infection in Brazilian and Italian individuals

Silva, G.K. da; Vianna, Priscila; Veit, Tiago Degani; Crovella, Sérgio; Catamo, Eulalia; Cordero, Elvira Alicia Aparicio; Mattevi, Vanessa Suñé; Lazzaretti, Rosmeri Kuhmmer; Sprinz, Eduardo; Kuhmmer, Regina; Chies, José Artur Bogo

doi:10.1016/j.meegid.2013.12.013

Cited by 41 publications

(36 citation statements)

References 36 publications

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“…Actually, more studies indicate that single‐nucleotide polymorphism such as 14‐bp insertion/deletion and +3142 C>G polymorphisms at 3′ untranslated region (3′UTR) may affect the stability of HLA‐G mRNA, thereby influencing HLA‐G expression . Therefore, further studies suggested that HLA‐G polymorphisms were related to susceptibility to viral infection . (ii) The interference of viral proteins with HLA‐G intracellular trafficking: it has been reported that HLA‐G expression is induced by viral proteins of many virus such HIV‐1 which can induce the expression of HLA‐G isoforms on monocytes and lymphocytes by an indirect effect of viral products .…”

Section: Discussionmentioning

confidence: 99%

Increased levels of soluble HLA‐G molecules in Tunisian patients with chronic hepatitis B infection

Laaribi

Bortolotti

Hannachi

et al. 2017

Journal of Viral Hepatitis

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Hepatitis B virus (HBV) infection is a global health problem. The mechanisms of immune tolerance in HBV infection are still unclear. The host immune response plays a critical role in determining the outcome of HBV infection. Human leucocyte antigen-G (HLA-G) is involved in immunotolerogenic process and infectious diseases. This study aimed to explore the implication of soluble HLA-G (sHLA-G) and its isoforms in HBV infection. Total sHLA-G (including shedding HLA-G1 and HLA-G5) was analysed by ELISA in 95 chronic HBV patients, 83 spontaneously resolvers and 100 healthy controls (HC). To explore the presence of sHLA-G dimers, we performed an immunoprecipitation and a Western blot analysis on positive samples for sHLA-G in ELISA. The serum levels of sHLA-G were significantly increased in patients with chronic HBV patients compared to spontaneously resolvers and HC (P<.0001). Interestingly, we found an increased level of sHLA-G1 in chronic HBV patients than in spontaneously resolvers and HC (P<.001). In addition, the expression of HLA-G5 seems to be higher in the sera of chronic HBV patients than spontaneously resolvers (P=.026). The analysis of HLA-G dimers showed the presence of homodimers in 93% of chronic HBV patients, 67% in spontaneously resolvers and 60% in HC. These results provide evidence that sHLA-G may have a crucial role in the outcome of HBV infection and could be proposed as a biomarker for infection outcome. Based on its tolerogenic function, HLA-G might be considered as a new promising immunotherapeutic approach to treat the chronic infection with HBV.

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Section: Discussionmentioning

confidence: 99%

Increased levels of soluble HLA‐G molecules in Tunisian patients with chronic hepatitis B infection

Laaribi

Bortolotti

Hannachi

et al. 2017

Journal of Viral Hepatitis

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“…It has been postulated that HLA-G alleles that have higher HLA-G expression would exert greater NK and CD8+ T cell inhibition, which could result in the decreased ability of these cells to target viral-infected cells and thus increasing the risk for HIV-1 transmission (da Silva et al, 2014, Luo et al, 2013, Matte et al, 2004, Moodley and Bobat, 2011). In agreement with this hypothesis, placental expression of HLA-G was 3.9 times more up-regulated in transmitting mothers compared to non-transmitting mothers (Moodley and Bobat, 2011).…”

Section: Discussionmentioning

confidence: 99%

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Hong

Paximadis

Gray

et al. 2015

Infection, Genetics and Evolution

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A 14-bp insertion/deletion (indel) within the 3' untranslated region (3’UTR) that affects HLA-G expression has been associated with HIV-1 mother-to-child transmission (MTCT). However, other 3’UTR single nucleotide polymorphisms (SNPs) that influence HLA-G mRNA stability have been described but not analyzed in the context of MTCT, and little is known about the role of HLA-G alleles. We examined HLA-G alleles and 3’UTR SNPs, including the 14-bp indel, in 216 mother-infant pairs from Johannesburg, South Africa. Mother-infant pairs were classified as HIV-1 non-transmitting (NT, n=144) or HIV-1 transmitting (TR, n=72) with either intrapartum (IP, n=29) or in utero (IU, n=19) infected infants. We found HLA-G allele, G*01:01:02 (in strong linkage disequilibrium with the 14-bp insertion) and +3187G SNP were significantly over-represented in IU-TR mothers compared to NT mothers (P=0.036, OR=2.26; P=0.011, OR=2.96, respectively). These findings suggest that maternal HLA-G alleles and/or SNPs that might alter expression of HLA-G potentially influence IU HIV-1 MTCT.

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“…Seven polymorphisms at the 3′ UTR are reported to play a role in HLA-G expression: a 14 bp insertion/deletion (INS/DEL) rs1704 polymorphism (251), and the SNPs +3003 T/C, +3010 G/C, +3035 C/T, +3142 C/G, +3187 A/G, +3196 C/G (252). The 14 bp INS/DEL polymorphism plays a role in alternative splicing, which removes 92 bp, including the region where the 14 bp region is resulting in a higher yield of stable HLA-G mRNA transcripts in vitro (253).…”

Section: The Complex Role Of Hla-g In Immunomodulationmentioning

confidence: 99%

Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

2017

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The genetic factors associated with susceptibility or resistance to viral infections are likely to involve a sophisticated array of immune response. These genetic elements may modulate other biological factors that account for significant influence on the gene expression and/or protein function in the host. Among them, the role of the major histocompatibility complex in viral pathogenesis in particular human immunodeficiency virus (HIV) and hepatitis C virus (HCV), is very well documented. We, recently, added a novel insight into the field by identifying the molecular mechanism associated with the protective role of human leukocyte antigen (HLA)-B27/B57 CD8+ T cells in the context of HIV-1 infection and why these alleles act as a double-edged sword protecting against viral infections but predisposing the host to autoimmune diseases. The focus of this review will be reexamining the role of classical and non-classical HLA alleles, including class Ia (HLA-A, -B, -C), class Ib (HLA-E, -F, -G, -H), and class II (HLA-DR, -DQ, -DM, and -DP) in immune regulation and viral pathogenesis (e.g., HIV and HCV). To our knowledge, this is the very first review of its kind to comprehensively analyze the role of these molecules in immune regulation associated with chronic viral infections.

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Influence of HLA-G polymorphisms in human immunodeficiency virus infection and hepatitis C virus co-infection in Brazilian and Italian individuals

Cited by 41 publications

References 36 publications

Increased levels of soluble HLA‐G molecules in Tunisian patients with chronic hepatitis B infection

Increased levels of soluble HLA‐G molecules in Tunisian patients with chronic hepatitis B infection

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

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