Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Hong, Heather A.; Paximadis, Maria; Gray, Glenda; Kuhn, Louise; Tiemessen, Caroline T.

doi:10.1016/j.meegid.2014.12.021

Cited by 14 publications

(13 citation statements)

References 52 publications

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“…When analysing the role of HLA-G in the vertical (mother to child) transmission (Hong et al, 2015), it was found that the HLA-G allele, G( * )01:01:02 (in strong linkage disequilibrium with the 14-bp insertion) and +3187G SNP were significantly overrepresented in transmitters mothers compared to nontransmitter mothers, suggesting that polymorphisms of this gene may be relevant in this maternal transmission. Table 2 shows some viral infections associated with HLA-G.…”

Section: Chronic Viral Infectionsmentioning

confidence: 99%

HLA‐G: Function, polymorphisms and pathology

Arnaiz‐Villena

Juárez

Suárez-Trujillo

et al. 2020

Int J Immunogenetics

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HLA‐G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA‐G function, polymorphism and pathology that have been confirmed by several different researchers, together with exposing aspects that may have been overlooked or not sufficiently remarked in this productive field of study. On the other hand, we question whether performing mainly studies on HLA‐G and disease associations is going to give a clear answer in the future, since 40 years of study of classical HLA molecules association with disease has still given no definite answer on this issue.

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Section: Chronic Viral Infectionsmentioning

confidence: 99%

HLA‐G: Function, polymorphisms and pathology

Arnaiz‐Villena

Juárez

Suárez-Trujillo

et al. 2020

Int J Immunogenetics

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“…In vitro , transfection of the 14-bp ins/ins HLA-G into K562 cells resulted in increased levels of membrane-bound HLA-G1 expression with higher mRNA stability and lower sHLA-G1 ratio ( 257 ). However, studies on the impact of the 14-bp insertion on HIV-1 vertical transmission risk report conflicting results ( 258 – 260 ). In horizontal transmission, the frequency of the 14-bp ins/ins genotype was enriched in HIV-1–infected patients in African (but not European) subjects ( 261 ).…”

Section: Introductionmentioning

confidence: 99%

Natural Killer Cell Interactions with Classical and Non-Classical Human Leukocyte Antigen Class I in HIV-1 Infection

2017

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Natural killer (NK) cells are effector lymphocytes of the innate immune system that are able to mount a multifaceted antiviral response within hours following infection. This is achieved through an array of cell surface receptors surveilling host cells for alterations in human leukocyte antigen class I (HLA-I) expression and other ligands as signs of viral infection, malignant transformation, and cellular stress. This interaction between HLA-I ligands and NK-cell receptor is not only important for recognition of diseased cells but also mediates tuning of NK-cell-effector functions. HIV-1 alters the expression of HLA-I ligands on infected cells, rendering them susceptible to NK cell-mediated killing. However, over the past years, various HIV-1 evasion strategies have been discovered to target NK-cell-receptor ligands and allow the virus to escape from NK cell-mediated immunity. While studies have been mainly focusing on the role of polymorphic HLA-A, -B, and -C molecules, less is known about how HIV-1 affects the more conserved, non-classical HLA-I molecules HLA-E, -G, and -F. In this review, we will focus on the recent progress in understanding the role of non-classical HLA-I ligands in NK cell-mediated recognition of HIV-1-infected cells.

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“…SNP 3206 (rs9380142) has been previously associated with HIV infection [65]. In our study, the AA genotype distribution was significantly different between HIV-uninfected and infected PE groups.…”

Section: Discussionmentioning

confidence: 42%

HLA-G Polymorphisms Associated with HIV Infection and Preeclampsia in South Africans of African Ancestry

Phoswa

Ramsuran

Naicker

et al. 2020

BioMed Research International

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Objectives. HLA-G, part of the major histocompatibility complex (MHC), is associated with the risk of developing preeclampsia (PE). In this study, we determined the contribution of specific HLA-G polymorphisms on the risk of developing preeclampsia in HIV-infected and uninfected South Africans of African ancestry. Methods. One hundred and ninety-three women of African ancestry were enrolled (74 HIV-uninfected normotensive, 60 HIV-infected normotensive, 34 HIV-uninfected, and 25 HIV-infected preeclamptics). Sanger sequencing of the untranslated region was performed to genotype six SNPs, i.e., 14 bp Ins/Del of rs66554220, rs1710, rs1063320, rs1610696, rs9380142, and rs1707). Results. For rs66554220, we have the following results: (a) based on pregnancy type—the Ins/Ins and Del/Ins genotype frequency was higher in preeclampsia (PE) compared to normotensive pregnancies (Ins/Ins vs. Del/Ins, P=0.02∗: OR 95%CI=13.44 0.7222–249.9; Del/Del vs. Del/Ins, P=0.03∗: OR 95%CI=2.95 1.10–7.920); (b) based on HIV status—the Ins/Ins showed both genotypic and allelic association with HIV infection. HIV-infected PE has higher Ins/Ins genotypic and allelic frequencies compared to HIV-uninfected PE (Ins/Ins vs. Del/Ins, P=0.005∗∗: OR 95%CI=21.32 1.71–4.17; Ins, P=0.005∗∗; OR 95%IC=21.32 1.71–4.17). For rs1707, we have the following results: (a) based on pregnancy type—there were CT genotypic frequencies in PE, more especially LOPE compared to normotensive pregnancies (TT vs. CT, P=0.0092∗∗: OR 95%CI=5.1.39−25.64), and no allelic association was noted; (b) based on HIV status—CT was higher in HIV-infected LOPE compared to uninfected LOPE (TT vs. TC, P=0.0006∗∗∗: OR 95%CI=40.00 2.89−555.1). For rs1710 and rs1063320, no significant differences in the genotype and allele frequencies were noted based on pregnancy type and HIV status. For rs9380142, we have the following results: (a) based on pregnancy type—no significant differences were noted between normotensive compared to PE pregnancies; (b) based on HIV status—AA genotypes occurred more in the HIV-infected PE group (AA vs. GG, P=0.02∗: OR 95%CI=13.97 0.73−269.4), while A allelic frequency occurred more in HIV-infected PE, especially LOPE compared to uninfected groups (A vs. G, P=0.0003∗∗∗: OR 95%CI=10.72 2.380−48.32; P=0.02∗: OR 95%CI=9.00 1.07−75.74). For rs1610696, we have the following results: (a) based on pregnancy type—genotypic and allelic frequencies of CC were higher in PE compared to normotensive pregnancies (CC vs. GG, P=0.0003∗∗∗: OR 95%CI=31.87 1.861−545.9; C, P=0.0001∗∗∗: OR 95%IC=21.91 2.84−169.0); (b) based on HIV status—GG frequencies were higher in the HIV-infected PE more especially LOPE groups (GG vs. GC, P=0.02∗: OR 95%CI=16.87 0.81−352.1; GG vs. CC, P=0.0001∗∗∗: OR 95%CI=159.5 13.10−1942). Conclusion. Selected HLA-G 14 bp polymorphisms (Ins/Ins) and genotypic and allelic differences in rs9380142, rs1610696, and rs1707 are associated with the pathogenesis of preeclampsia in HIV-infected South African women of African ancestry. More genetic studies evaluating the association between preeclampsia and HIV infection are needed to improve diagnosis and antenatal care.

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Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

Cited by 14 publications

References 52 publications

HLA‐G: Function, polymorphisms and pathology

HLA‐G: Function, polymorphisms and pathology

Natural Killer Cell Interactions with Classical and Non-Classical Human Leukocyte Antigen Class I in HIV-1 Infection

HLA-G Polymorphisms Associated with HIV Infection and Preeclampsia in South Africans of African Ancestry

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