Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

Crux, Nicole B.; Elahi, Shokrollah

doi:10.3389/fimmu.2017.00832

Cited by 158 publications

(147 citation statements)

References 356 publications

(444 reference statements)

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“…Severe diarrhoea is a cause of systemic inflammation and may also lead to ischemic injury to grafts because of dehydration or volume depletion . Recently, growing evidence has indicated that production of DSA is attributable to increased alloreactivity by multiple types of infections, including Cytomegalovirus . In the present study, the infectious and non‐infectious diarrhoea groups showed an elevated risk of DSA, despite different classes of DSA and the dependence on the change in immunosuppressive regimen.…”

Section: Discussionmentioning

confidence: 48%

Effect of severe diarrhoea on kidney transplant outcomes

Kim

et al. 2019

Nephrology

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Aim In addition to immunological complications, non‐immunological events should be considered following kidney transplantation. Among them, diarrhoea is the most common gastrointestinal complication, but its effect on transplant outcomes remains unclear. Methods This retrospective study enrolled patients who underwent kidney transplantation between May 1993 and December 2017. Patients with diarrhoea as the chief complaint at admission were defined as the diarrhoea group. Transplant outcomes were compared between the diarrhoea and non‐diarrhoea groups. Results Among a total of 1704 kidney recipients, severe diarrhoea that required hospitalization was identified in 84 (4.9%) patients. Patients with diarrhoea showed higher risks of graft failure (adjusted hazard ratio, 4.77 (2.98–7.64)) and all‐cause mortality (adjusted hazard ratio, 7.17 (4.09–12.58)) than did patients without diarrhoea. The risk of de novo donor‐specific antibody was also elevated in the diarrhoea group, although there was no change in the risk of biopsy‐proven rejection. In subgroup analysis, the aetiology of diarrhoea, as well as a change in immunosuppressant following diarrhoea, showed no significant differences in graft survival. However, incomplete recovery from concurrent acute kidney injury was significantly associated with graft loss. Conclusion Diarrhoea is related to poor graft and patients’ outcomes in kidney recipients. An effort to recover from concurrent acute kidney injury is important for improved graft survival.

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Section: Discussionmentioning

confidence: 48%

Effect of severe diarrhoea on kidney transplant outcomes

Kim

et al. 2019

Nephrology

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“…HLA‐II genes have a substantial role in the formation of HIV CD4+ T cell syncytia. However, the HIV‐infected subjects fail to present an immune response to this region …”

Section: Discussionmentioning

confidence: 99%

“…HLA-II genes have a substantial role in the formation of HIV CD4+ T cell syncytia. However, the HIV-infected subjects fail to present an immune response to this region 30. Tumor necrosis factor (TNF), as a proinflammatory cytokine, has several functions in different diseases including cell differentiation, necrosis, proliferation, and apoptosis.…”

mentioning

confidence: 99%

Reconnaissance of the candidate genes involved in the pathogenesis of human immunodeficiency virus and targeted by antiretroviral therapy

Mozhgani

Ghobadi

Rad

et al. 2019

Journal of Medical Virology

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The expression levels of many genes change after treatment of human immunodeficiency virus (HIV)‐infected subjects by antiretroviral drugs. High‐throughput analysis of tremendous datasets led to the discovery of genes that are implicated in the treatment pathways. In this study, we performed a gene‐enrichment analysis after determining the differentially expressed genes (DEGs) between untreated HIV‐positive and HIV‐negative subjects and also between treated HIV‐positive subjects with antiretroviral therapy (ART; who receiving nucleoside reverse transcriptase inhibitor–based ART) and untreated HIV‐positive cases in the peripheral blood mononuclear cells (PBMCs), adipose, and muscle tissues. In sum, the genes that activate inflammatory, immune response, proliferation, metabolism, and viral involvement pathways have different expression patterns in the untreated HIV‐positive subjects and treated HIV‐positive cases. Moreover, the expression levels of the genes including ACLY, ALDH18A1, HADHA, and YARS in the PBMCs tissue and HBEGF, PKN3, DEGS2, and EDN3 in the fat tissue were found to be different in the HIV‐infected patients, which can be considered as new biomarkers for HIV infection.

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“…138 Now, antibody-binding sites in a given HLA (MHC) molecule are mostly prediction-servers predetermined on the basis of particular binding motifs and the anchor residues. 139,140 These residues refer to known amino acids located at defined locations in the peptide chain and which are peculiar to each MHC molecule. 141,142 Prediction-server database of peptide motifs and/or of MHC ligands may be obtained from web-based and/or from prediction-servers dedicated to NetMHC family.…”

Section: The Subpopulation Levelmentioning

confidence: 99%

<p>Immunoinformatics and Vaccine Development: An Overview</p>

Oli

Obialor

Ifeanyichukwu

et al. 2020

ITT

161

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The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system. Even at the face of potential vaccine design advance, immune-related concerns (as seen with specific vulnerable populations, cases of emerging/reemerging infectious disease, pathogens with complex lifecycle and antigenic variability, need for personalized vaccinations, and concerns for vaccines' immunological safety -specifically vaccine likelihood to trigger non-antigen-specific responses that may cause autoimmunity and vaccine allergy) are being raised. And these concerns have driven immunologists toward research for a better approach to vaccine design that will consider these challenges. Currently, immunoinformatics has paved the way for a better understanding of some infectious disease pathogenesis, diagnosis, immune system response and computational vaccinology. The importance of this immunoinformatics in the study of infectious diseases is diverse in terms of computational approaches used, but is united by common qualities related to host-pathogen relationship. Bioinformatics methods are also used to assign functions to uncharacterized genes which can be targeted as a candidate in vaccine design and can be a better approach toward the inclusion of women that are pregnant into vaccine trials and programs. The essence of this review is to give insight into the need to focus on novel computational, experimental and computation-driven experimental approaches for studying of host-pathogen interactions and thus making a case for its use in vaccine development.

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Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

Cited by 158 publications

References 356 publications

Effect of severe diarrhoea on kidney transplant outcomes

Effect of severe diarrhoea on kidney transplant outcomes

Reconnaissance of the candidate genes involved in the pathogenesis of human immunodeficiency virus and targeted by antiretroviral therapy

<p>Immunoinformatics and Vaccine Development: An Overview</p>

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