Influence of Formulation Change on Drug Release Kinetics from Hydroxypropylmethylcellulose Matrix Tablets.

Xu, Guojie; Sunada, Hisakazu

doi:10.1248/cpb.43.483

Cited by 103 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The low adhesion force values of FI may be due to its high content of MCC causing a discontinuity in the gel structure. 31 In the case of FII, the adhesion force slightly increased with an increase in applied weight from 2 to 10 g. FII has the highest content of negative charge among all the formulations, which decreases the net positive charge of chitosan available for adhesion. The force required for detachment increased slightly with the applied weight, probably due to better contact with the mucus layer.…”

Section: Aaps Pharmscimentioning

confidence: 88%

Chitosan and sodium alginate—Based bioadhesive vaginal tablets

El-Kamel

Sokar

Naggar

et al. 2002

AAPS J

108

View full text Add to dashboard Cite

Metronidazole was formulated in mucoadhesive vaginal tablets by directly compressing the natural cationic polymer chitosan, loosely cross-linked with glutaraldehyde, together with sodium alginate with or without microcrystalline cellulose (MCC). Sodium carboxymethylcellulose (CMC) was added to some of the formulations. The drug content in tablets was 20%. Drug dissolution rate studies from tablets were carried out in buffer pH 4.8 and distilled water. Swelling indices and adhesion forces were also measured for all formulations. The formula (FIII) containing 6% chitosan, 24% sodium alginate, 30% sodium CMC, and 20% MCC showed adequate release properties in both media and gave lower values of swelling index compared with the other examined formulations. FIII also proved to have good adhesion properties with minimum applied weights. Moreover, its release properties (% dissolution efficiency, DE) in buffer pH 4.8, as well as release mechanism (n values), were negligibly affected by aging. Thus, this formula may be considered a good candidate for vaginal mucoadhesive dosage forms.

show abstract

Section: Aaps Pharmscimentioning

confidence: 88%

Chitosan and sodium alginate—Based bioadhesive vaginal tablets

El-Kamel

Sokar

Naggar

et al. 2002

AAPS J

108

View full text Add to dashboard Cite

show abstract

“…For the comparison of the formulations, the f 2 factor analysis was used (18). The release data of all formulations were fit to a first-order release model (19,20) and then compared with one other. Flux (J) was calculated as µg/h/cm 2 (21,22).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Release of Indian Penny Wort, Walnut, and Turmeric from Topical Preparations Using Two Different Types of Membranes

Khiljee¹,

Rehman²,

Sarfaz³

et al. 2010

Dissolution Technol.

View full text Add to dashboard Cite

Herbal remedies like the Indian penny wort, walnut, and turmeric are useful in traditional medicine for the treatment of many skin diseases, especially eczema. The aim of the present study was to formulate a microemulsion, a gel, and an ointment containing these plant extracts and to evaluate their in vitro release using markers. The in vitro release was assessed using Franz cells and two different types of membranes, nylon and cellulose. The three formulations showed different releases, except for the microemulsion and gel of Indian penny wort and walnut, which had similar release profiles. The study showed that the nylon membrane had a faster release than the cellulose membrane. However, first-order release kinetics for all three formulations were only observed for the cellulose membrane. In this study, the cellulose membrane showed more discriminative power to differentiate among the three tested herbs and their formulations. This demonstrates that it is important to investigate the impact of the membrane on the release pattern of different formulations. In vitro diffusion cell experiments can be used to develop improved formulations of traditional medicines.

show abstract

“…Diltiazem HCl is an antihypertensive agent which is widely used in the treatment of hypertension and angina [8]. It also inhibits ergonovine-induced and spontaneous coronary artery spasms [9]. The main objective of the present study was the development of once a day controlled release matrix tablets of Diltiazem HCl with Ethocel 45 Premium, K100 LV Methocel and K15M EP Premium Methocel as rate controlling agents.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Controlled Release Matrix Tablets of Diltiazem Hydrochloride Using Different Rate Controlling Polymers

Razaque¹,

Khan²,

Danish³

et al. 2016

Open Conf. Proceed. J.

View full text Add to dashboard Cite

In present study, directly compressed controlled released matrix tablets of Diltiazem Hydrochloride were formulated at drug-to-polymer ratios (D: P) of 10:1, 10:2, 10:3 using polymers Ethocel 45 Premium, K100 LV Methocel, K15M EP Premium Methocel as rate controlling agents. In some formulations of Diltiazem hydrochloride and Ethocel 45 Premium matrices, 30% of filler was replaced by Co-excipient like HPMC, CMC-Na and Starch. The in vitro dissolution studies were performed according to USP Method-I (rotating basket method). Phosphate buffer (pH 7.4) was used as dissolution medium and the rotation speed of baskets were kept constant at 100rpm and temperature of the medium was maintained at 37 ± 0.1°C. In order to determine the drug release kinetics various models such as Ist-order, Zero-order, Hixon Crowell, Highuchi and Power Law were applied. Herbesser ® tablets were used as reference standard for comparison of dissolution profiles of standard and tests formulation by applying difference factor (f 1 ) and similarity factor (f 2 ). The rate controlling agents extended the drug release rates but Ethocel 45 Premium extended more efficiently than the K100 LV Methocel and K15M EP Premium Methocel containing matrices. These newly prepared formulations released the drug mostly by anomalous non Fickian drug diffusion. The drug release profiles of the test formulations were different from the drug release profile of reference standard formulation (Herbesser ® tablets). The Co-excipients increased the drug released from the matrices containing Ethocel 45 premiums. Ethocel 45 Premium, K100 LV Methocel and K15M EP Premium Methocel can be effectively used as rate controlling agents in formulation of directly controlled release matrix tablets.

show abstract

Influence of Formulation Change on Drug Release Kinetics from Hydroxypropylmethylcellulose Matrix Tablets.

Cited by 103 publications

References 0 publications

Chitosan and sodium alginate—Based bioadhesive vaginal tablets

Chitosan and sodium alginate—Based bioadhesive vaginal tablets

In Vitro Release of Indian Penny Wort, Walnut, and Turmeric from Topical Preparations Using Two Different Types of Membranes

Formulation and Evaluation of Controlled Release Matrix Tablets of Diltiazem Hydrochloride Using Different Rate Controlling Polymers

Contact Info

Product

Resources

About