Examination was made of the release of indomethacin from hydroxypropylmethylcellulose (HPMC) matrices and the results were found to usually follow first order release kinetics. The release mechanism changed with formulation. HPMC content was the predominant controlling factor. As the HPMC content increased, drug release rate decreased, and the release mechanism gradually changed from Higuchi diffusion release to case II transport. Additives increased the release rate and enhanced Fickian diffusion. As drug content increased, release rate calculated from percent release data decreased while that calculated from mg release data increased. When indomethacin content was lower, drug release was diffusion controlled and when higher, non-Fickian transport or case II transport was apparent. Additive effects were also examined. Starch was found to most effectively maintain case II release. Complex additives containing starch were superior to any additive by itself. A multiple regression model was used to determine the relationship between response (release rate) and factors (content of HPMC and diluents), and on the basis of this model a formulation was established and found valid by agreement with data from the regression model.

Particulate matter is one of the main pollutants, causing hazy days, and it has been serious concern for public health worldwide, particularly in China recently. Quality of outdoor atmosphere with a pollutant emission of PM2.5 is hard to be controlled; but the quality of indoor air could be achieved by using fibrous membrane-based airfiltering devices. Herein, we introduce nanofiber membranes for both indoor and outdoor air protection by electrospun synthesized polyacrylonitrile:TiO 2 and developed polyacrylonitrile-co-polyacrylate:TiO 2 composite nanofiber membranes. In this study, we design both polyacrylonitrile:TiO 2 and polyacrylonitrile-co-polyacrylate:TiO 2 nanofiber membranes with controlling the nanofiber diameter and membrane thickness and enable strong particulate matter adhesion to increase the absorptive performance and by synthesizing the specific microstructure of different layers of nanofiber membranes. Our study shows that the developed polyacrylonitrile-co-polyacrylate: TiO 2 nanofiber membrane achieves highly effective (99.95% removal of PM2.5) under extreme hazy air-quality conditions (PM2.5 mass concentration 1 mg/m 3 ). Moreover, the experimental simulation of the test in 1 cm 3 air storehouse shows that the polyacrylonitrile-co-polyacrylate:TiO 2 nanofiber membrane (1 g/m 2 ) has the excellent PM 2.5 removal efficiency of 99.99% in 30 min.

No abstract

Multi-needle electrospinning technology is a method for mass production of nanofibers, which can improve the production efficiency of nanofibers by increasing the number and density of needles for multi-needle electrospinning. However, when the arrangement density of the needle is high, the electric field of the needle tip is not uniform, causing instability such as jet dripping and broken jet. In this paper, the electric field uniformity optimization problem of multi-needle electrospinning technology is used to simulate the needle tip electric field by using COMSOL finite element analysis software. The influence of the needle size and the dielectric material on the electric field of the tip was studied. Finally, the method of using dielectric material on the tip of the middle part of the needle is beneficial to the electric field uniformity. The uniformity of the needle tip electric field in the case of high-density arrangement of the needle is realized, and the nozzle is provided for mass production of nanofibers by multi-needle electrospinning.

No abstract