Influence of Fluctuating Water Temperature and Dietary Oxytetracycline on the Safety of Monosex Nile Tilapia Oreochromis niloticus Fries

Roy, Anwesha; Abraham, Thangapalam Jawahar; Julinta, Roy Beryl; Singha, Jasmine; Boda, Satyanarayana; Dash, Gadadhar; Nagesh, T. S.; Sar, Tapas Kumar; Patil, Prasanna Kumar

doi:10.1007/s00128-021-03227-2

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…The kidney is used as a good indicator of the toxic effects of drugs (Bardhan, Abraham, Singha, Sar, et al, 2022; Zhang et al, 2021) because it receives high post‐brachial blood. A dose‐dependent degeneration of renal epithelium and vacuolation suggested the toxic effects of OA due to long‐term feeding similar to several earlier studies with florfenicol (Bardhan, Abraham, Singha, Saha, et al, 2022; Bardhan, Abraham, Singha, Sar, et al, 2022), oxytetracycline (Julinta et al, 2019; Roy et al, 2021) and other antibiotics (Limbu et al, 2021). However, the increased intensity of degenerated renal epithelium and vacuolation suggested that vacuolation precedes degeneration (Seely et al, 2019).…”

Section: Discussionsupporting

confidence: 82%

Safety, tolerability and biological responses of Oreochromis niloticus juveniles upon oral oxolinic acid administration

Abraham,

Patel,

Bardhan

et al. 2023

Vet Pharm & Therapeutics

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In aquaculture, oxolinic acid (OA) is used as a second‐line treatment at 12 mg/kg biomass/day for seven consecutive days. The present study evaluated the biosafety of 21 days of dietary administration of OA at 0, 12, 36, 60 and 120 mg by assessing the growth, biochemical, erythrocytic morphological and histopathological alterations and residue levels in Oreochromis niloticus. A significant dose‐dependent reduction in feed intake and biomass and an increase in mortalities and erythrocytic cellular and nuclear changes were recorded. Significant elevations in plasma glucose, creatinine, alkaline phosphatase, alanine transaminase and aspartate transaminase and a decline in calcium and chloride levels were documented. The kidney, liver and intestine histoarchitecture showed mild to marked alterations. The edible tissue OA residues peaked on day 21 and decreased upon cessation of administration in all the dosing groups. The residue levels in the muscle of the recommended dose group were well within the maximum residue limit set by the European Medicines Evaluation Agency. Although the current study hinted at the safety and tolerability of OA even during long‐term usage in O. niloticus in Indian conditions, care must be exercised for its aquacultural application because of its listing as a critically important medicine for humans.

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