Safety, tolerability and biological responses of Oreochromis niloticus juveniles upon oral oxolinic acid administration
Thangapalam Jawahar Abraham,
Jaykumar Bhagubhai Patel,
Avishek Bardhan
et al.
Abstract:In aquaculture, oxolinic acid (OA) is used as a second‐line treatment at 12 mg/kg biomass/day for seven consecutive days. The present study evaluated the biosafety of 21 days of dietary administration of OA at 0, 12, 36, 60 and 120 mg by assessing the growth, biochemical, erythrocytic morphological and histopathological alterations and residue levels in Oreochromis niloticus. A significant dose‐dependent reduction in feed intake and biomass and an increase in mortalities and erythrocytic cellular and nuclear c… Show more
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