Influence of endocrine active compounds on the developing rodent brain

Patisaul, Heather B.; Polston, Eva K.

doi:10.1016/j.brainresrev.2007.06.008

Cited by 77 publications

(54 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fourth, the results from human studies are consistent with previous animal research, which has reported neurodevelopmental impairments (Betz et al, 2013;Hoshi and Ohtsuka, 2009;Li et al, 2013). Finally, as phthalates disrupt the endocrine system by binding to androgens, which mediate the development of sex-specific behaviors, including aggression and anxiety (Patisaul and Polston, 2008), our findings of sex differences in cognitive and behavioral outcomes in children exposed prenatal exposure are biologically plausible.…”

Section: Strengths and Limitationssupporting

confidence: 89%

Phthalate exposure and childrens neurodevelopment: A systematic review

Ejaredar

Nyanza

Eycke

et al. 2015

Environmental Research

235

132

View full text Add to dashboard Cite

Section: Strengths and Limitationssupporting

confidence: 89%

Phthalate exposure and childrens neurodevelopment: A systematic review

Ejaredar

Nyanza

Eycke

et al. 2015

Environmental Research

235

132

View full text Add to dashboard Cite

“…The perinatal low-dose BPA exposure had no obvious effect on the reproductive physiology of their offspring, as deduced by observations of anogenital distance, puberty onset, ovarian histology and vaginal smears, in agreement with the literature regarding low-dose exposures (Ashby 2001, Rubin et al 2001, Tinwell et al 2002, Yoshida et al 2004, Patisaul & Polston 2008, Poimenova et al 2010. However, the reduced male:female offspring ratio in BPA-treated dams, though not statistically significant in this study, may imply a male embryo selective vulnerability in utero that worth further investigation.…”

Section: Reproductive Physiologysupporting

confidence: 90%

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats

Panagiotidou¹,

Zerva²,

Mitsiou³

et al. 2013

Journal of Endocrinology

View full text Add to dashboard Cite

Bisphenol A (BPA) is an estrogen-mimicking endocrine disruptor. Early-life exposures to low doses of BPA exert long-lasting effects on animals' reproductive and brain physiology. However, little is known about the effects of BPA on the stress-response system. Given the interaction of sex and stress hormones, we examined the effect of a low perinatal BPA exposure on the function of the hypothalamic-pituitary-adrenal (HPA) axis at rest and upon application of acute stress. Throughout pregnancy and lactation rats received daily 40 mg BPA/kg body weight orally via cornflakes. We studied the effect of this low but chronic exposure to BPA in the male and female offspring at puberty. BPA exposure led to abnormal adrenal histology including reduced zona reticularis especially in male offspring, hyperplasia of zona fasciculata in both sexes, and increased adrenal weight in female offspring. BPA-treated females had increased basal corticosterone and reduced hypothalamic glucocorticoid receptors (GR) levels. Stressed BPA-exposed females exhibited anxiety-like behavioral coping, a less rigorous corticosterone response, and did not downregulate GR in the hypothalamus, compared with control females. BPA-exposed males exhibited a heightened corticosterone stress response compared with females; they also displayed increased pro-opiomelanocortin mRNA levels and retained the prestress levels of pituitary corticotropin-releasing hormone-receptor 1, compared with control males. We found that perinatal chronic exposure to a low dose of BPA perturbs the basal and stress-induced activity of the HPA axis in a sexually dimorphic manner at adolescence. Exposure to BPA might contribute to increased susceptibility to stress-related disorders in later life.

show abstract

“…This was indirectly supported by a previous report showing adrenal hormones are necessary during the initiation phase of sensitization when observed after early withdrawal (1 day; Prasad et al 1996). Estrogen and its mimic have been proven to increase the probability and intensity of aggressive behavior (Moore et al 2004;Wisniewski et al 2005;Patisaul & Polston 2008). Several lines of evidence suggest that estrogen may facilitate aggression via ERα and inhibit aggression via ERβ (Nomura et al 2002;Scordalakes & Rissman 2004).…”

Section: Effects Of Cocaine On Female Mandarin Volessupporting

confidence: 58%

Effects of cocaine on aggression and associated central ERα and oxytocin expression in ovariectomized and intact mandarin voles

Fang

Wang

Tai

2017

The European Zoological Journal

View full text Add to dashboard Cite

Ovarian hormones, especially estrogen, may facilitate drug use vulnerability in females. Oxytocin is of special relevance to females and an important neuroendocrine factor regulating drug use. Mandarin vole (Microtus mandarinus) is a monogamous rodent, with complex nonsexual social behavior. Here, we examined whether ovariectomy produces effects on cocaine-induced aggressive behaviors, estrogen receptor alpha (ERα) and oxytocin in virgin female mandarin voles. The data indicate that repeated cocaine exposure increased aggressive behavior and reduced levels of oxytocin expression in the paraventricular nucleus in ovariectomized and sham-operated females. In addition, cocaine reduced the levels of ERα expression in the medial nuclei of the amygdale in sham-operated females. In contrast, cocaine decreased ERα expression in the medial preoptic area and increased serum estradiol levels in ovariectomized females. These results suggest that ovariectomy influences the effects of cocaine on central levels of ERα and oxytocin expression and serum estrogen levels. The estrogen system acts in concert with oxytocin to regulate cocaine-induced aggressive behavior in virgin females.

show abstract

Influence of endocrine active compounds on the developing rodent brain

Cited by 77 publications

References 110 publications

Phthalate exposure and childrens neurodevelopment: A systematic review

Phthalate exposure and childrens neurodevelopment: A systematic review

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats

Effects of cocaine on aggression and associated central ERα and oxytocin expression in ovariectomized and intact mandarin voles

Contact Info

Product

Resources

About