Abstract:Ovarian hormones, especially estrogen, may facilitate drug use vulnerability in females. Oxytocin is of special relevance to females and an important neuroendocrine factor regulating drug use. Mandarin vole (Microtus mandarinus) is a monogamous rodent, with complex nonsexual social behavior. Here, we examined whether ovariectomy produces effects on cocaine-induced aggressive behaviors, estrogen receptor alpha (ERα) and oxytocin in virgin female mandarin voles. The data indicate that repeated cocaine exposure i… Show more
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