Phthalate exposure and childrens neurodevelopment: A systematic review

Ejaredar, Maede; Nyanza, Elias C.; Eycke, Kayla Ten; Dewey, Deborah

doi:10.1016/j.envres.2015.06.014

Cited by 235 publications

(141 citation statements)

References 41 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…27,44 Studies which assess the effects of phthalates exposure on children's neurodevelopment reported that boys are higher at risk for neurodevelopmental disorders. 45 In contrast to the literature, our study found no significant effects of gender on endocrine disruptors in either group.…”

Section: ____________________________________________________________contrasting

confidence: 56%

May BPA and phthalates have a role in etiopathogenesis of ADHD?

Öztop¹,

Demirci²,

Özmen³

et al. 2017

Anadolu Psikiyatri Derg

View full text Add to dashboard Cite

show abstract

Section: ____________________________________________________________contrasting

confidence: 56%

May BPA and phthalates have a role in etiopathogenesis of ADHD?

Öztop¹,

Demirci²,

Özmen³

et al. 2017

Anadolu Psikiyatri Derg

View full text Add to dashboard Cite

show abstract

“…For the phthalates, several studies have reported an increased risk of shortened anogenital distance and cardiac malformation after exposure during the first trimester of pregnancy [24, 25, 39]. By comparison, exposure to phthalates in the third trimester has been associated with a greater risk of preterm birth and adverse cognitive and behavioral outcomes in children [26, 27, 40]. Fetal Outcomes will also depend on the type of chemicals and the levels of exposure.…”

Section: Discussionmentioning

confidence: 99%

“…For example, release of plasticizers contained in MDs is enhanced by contact with lipophilic substances [9, 12, 40, 56]. Data on drugs in contact with the MDs are shown in the supplementary materials (Additional files 2 and 3).…”

Section: Discussionmentioning

confidence: 99%

Exposure of hospitalised pregnant women to plasticizers contained in medical devices

et al. 2017

View full text Add to dashboard Cite

BackgroundMedical devices (MDs) in polyvinyl chloride (PVC) are not a well-known source of exposure to plasticizers, in particular during pregnancy. Because of its toxicity, the di-(2-ethylhexyl) phthalate (DEHP) has been replaced by other plasticizers such as di (isononyl)-cyclohexane-1,2-dicarboxilic acid (DINCH), tri-octyltrimellitate (TOTM) and di-(isononyl) phthalate (DiNP). Our study aimed to quantify the plasticizers (DEHP and alternative plasticizers) contained in PVC medical devices used for hospitalised pregnant women and to describe which these MDs had been used (type, number, duration of exposure).MethodsThe plasticizers contained in the MDs used for daily care in the Obstetrics Department of a French University Hospital were extracted from PVC (after contact with a chloroform solution), identified and quantified by gas-chromatography-mass-spectrometry analysis. A total of 168 pregnant women hospitalised in the Obstetrics Department with at least one catheter were included in the observational study. The median number of MDs containing plasticizers used and the daily duration of exposure to the MDs were compared in three groups of pregnant women: “Pathology group” (women hospitalised for an obstetric disorder who did not give birth during this hospitalisation; n = 52), “Pathology and delivery group” (hospitalised for an obstetric disorder and who gave birth during this stay; n = 23) and “Delivery group” (admitted for planned or spontaneous delivery without obstetric disorder; n = 93).ResultsDiNP, TOTM and DINCH were the predominant plasticizers contained in the MDs at an amount of 29 to 36 g per 100 g of PVC. Women in the “Pathology group” (preterm labour or other pathology) were exposed to a median number of two MDs containing TOTM and one MD containing DiNP, fewer than those in the “Pathology and delivery group” (p < 0.05). Women in the “Pathology group” had a median exposure of 3.4 h/day to MDs containing DiNP and 8.2 h/day to MDs containing TOTM, longer than those in the “Delivery group” (p < 0.01).ConclusionsOur study shows that the medical management of pregnant women in a hospital setting entails exposure to MDs containing alternative plasticizers (DiNP, TOTM and DINCH).Electronic supplementary materialThe online version of this article (doi:10.1186/s12905-017-0398-7) contains supplementary material, which is available to authorized users.

show abstract

“…There is growing evidence about adverse obstetrical outcomes linked with in utero exposure to environmental contaminants such as spontaneous abortion, delayed fetal growth, premature birth, congenital malformations and impaired neural and cognitive development [2,3,4,5,6,7,8,9]. The International Federation of Gynecology and Obstetrics (FIGO) now recognizes these adverse health outcomes linked with prenatal exposure to environmental chemicals [1].…”

Section: Introductionmentioning

confidence: 99%

Perception of Environmental Risks and Health Promotion Attitudes of French Perinatal Health Professionals

Marie

Lémery

Vendittelli

et al. 2016

IJERPH

View full text Add to dashboard Cite

The exposure of pregnant women to environmental contaminants is a subject of international concern. However, the risk perception of these contaminants by health professionals (HP) has not been extensively investigated. The main objective of the PERI–HELPE study (Perception of Risk–HEaLth Professionals & Environment Study) was to assess the risk perception of environmental exposure of pregnant women by perinatal HPs. The secondary objectives were to describe the preventive attitudes of perinatal HPs concerning chemicals exposure of pregnant women and to identify the barriers to preventive attitude. A cross-sectional study was performed in 2015 in France. One hundred eighty-nine HPs (obstetricians, midwives, and general practitioners) replied to an online self-administered questionnaire (participation rate: 11%). Carbon monoxide, pesticides and lead were the contaminants most frequently perceived as a high risk for pregnant women. A minority of HPs asked women about their chemical exposure and advised them to reduce exposure. The lack of information, training and scientific evidence in environmental health were the main difficulties declared by the HPs to advise pregnant women. Despite the low response rate, our findings provide important information to encourage French health authorities to take into account the difficulties encountered by HPs and set up appropriate training programs in Environmental health.

show abstract

Phthalate exposure and childrens neurodevelopment: A systematic review

Cited by 235 publications

References 41 publications

May BPA and phthalates have a role in etiopathogenesis of ADHD?

May BPA and phthalates have a role in etiopathogenesis of ADHD?

Exposure of hospitalised pregnant women to plasticizers contained in medical devices

Perception of Environmental Risks and Health Promotion Attitudes of French Perinatal Health Professionals

Contact Info

Product

Resources

About