May BPA and phthalates have a role in etiopathogenesis of ADHD?

Öztop, Didem Behice; Demirci, Esra; Özmen, Sevgi; Kondolot, Meda; Kardaş, Fatih; Per, Hüseyin

doi:10.5455/apd.280093

Cited by 2 publications

(3 citation statements)

References 39 publications

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“… Excluded Exposure measured concurrent with outcome - Arbuckle et al (2016a), Arbuckle et al (2016b) , Cho et al (2010) , Chopra et al (2014) , Hu et al (2017) , Kardas et al (2015) , Kim et al (2009) , Kondolot et al (2016) , Oztop et al (2018) , Park et al (2014) , Park et al (2015) , Testa et al (2012) , Shoaff et al (2018) , Won et al (2016) ; Exposure measurement in blood - Kardas et al (2015) , Minatoya et al (2016) , Minatoya et al (2018) ; Exposure measurement based on type of flooring in home - Larsson et al (2009) ; Exposure measurement based on household dust, which likely does not represent total exposure - Philippat et al (2015) . C=cognition; M=motor; B=behavior; 1=infant behavior; S=social behavior; G=good; A=adequate; D=deficient; G/A=good for short chain phthalates, adequate for long chain phthalates; A/D=adequate for short chain phthalates, deficient for long chain phthalates; wk gest=weeks gestation.…”

Section: Figmentioning

confidence: 99%

“… Exposure measured concurrent with outcome - Arbuckle et al (2016a), Arbuckle et al (2016b) , Cho et al (2010) , Chopra et al (2014) , Hu et al (2017) , Kardas et al (2015) , Kim et al (2009) , Kondolot et al (2016) , Oztop et al (2018) , Park et al (2014) , Park et al (2015) , Testa et al (2012) , Shoaff et al (2018) , Won et al (2016) ; …”

Section: Figmentioning

confidence: 99%

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Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence

Radke

Braun

Nachman

et al. 2020

Environment International

163

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Objective: We performed a systematic review of the epidemiology literature to identify the neurodevelopmental effects associated with phthalate exposure. Data sources and study eligibility criteria: Six phthalates were included in the review: di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), butyl benzyl phthalate (BBP), and diethyl phthalate (DEP). The initial literature search (of PubMed, Web of Science, and Toxline) included all studies of neurodevelopmental effects in humans, and outcomes were selected for full systematic review based on data availability. Study evaluation and synthesis methods: Studies of neurodevelopmental effects were evaluated using criteria defined a priori for risk of bias and sensitivity by two reviewers using a domain-based approach. Evidence was synthesized by outcome and phthalate and strength of evidence was summarized using a structured framework. For studies of cognition and motor effects in children ≤4 years old, a random effects meta-analysis was performed. Results: The primary outcomes reviewed here are (number of studies in parentheses): cognition (14), motor effects (9), behavior, including attention deficit hyperactivity disorder (20), infant behavior (3), and social behavior, including autism spectrum disorder (7). For each phthalate/outcome combination, there was slight or indeterminate evidence of an association, with the exception of motor effects for BBP, which had moderate evidence. Conclusions and implications of key findings: Overall, there is not a clear pattern of association between prenatal phthalate exposures and neurodevelopment. There are several possible reasons for the observed null associations related to exposure misclassification, periods of heightened susceptibility, sex-specific effects, and the effects of phthalate mixtures. Until these limitations are adequately addressed in the epidemiology literature, these findings should not be interpreted as evidence that there are no neurodevelopmental effects of phthalate exposure. The views expressed are those of the authors and do not necessarily represent the views or policies of the U.S. EPA.

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Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence

Radke

Braun

Nachman

et al. 2020

Environment International

163

View full text Add to dashboard Cite

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“…Phthalates play an important role in the incidence of numerous neuropsychiatric disorders in humans such as Attention Deficit Hyperactivity Disorder (ADHD) [ 23 ], autism [ 24 ], and learning disabilities. Surprisingly, the prevalence of these impairments is higher in males [ 25 ].…”

Section: Dehp-induced Neurobehavioral Toxicitymentioning

confidence: 99%

Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review

Safarpour

Ghasemi-Kasman

Safarpour

et al. 2022

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Background: Di-2-Ethylhexyl phthalate (DEHP) is one of the essential phthalate metabolites that disrupt the function of endocrine glands and causes numerous effects on animals, humans, and the environment. Phthalates are widely used in the plastics industry. Low doses of DEHP increase neurotoxicity in the nervous system that has arisen deep concerns due to the widespread nature of DEHP exposure and its high absorption during brain development. Objective: This review article evaluated the impacts of DEHP exposure from birth to adulthood on neurobehavioral damages. Then, the possible mechanisms of DEHP-induced neurobehavioral impairment were discussed. Methodology: Peer-reviewed articles were extracted through Embase, PubMed, and Google Scholar till the year 2021. Results: The results showed that exposure to DEHP during pregnancy and infancy leads to memory loss and irreversible nervous system damage. Conclusion: Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.

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May BPA and phthalates have a role in etiopathogenesis of ADHD?

Cited by 2 publications

References 39 publications

Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence

Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence

Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review

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