Influence of Direct Laser Written 3D Topographies on Proliferation and Differentiation of Osteoblast‐Like Cells: Towards Improved Implant Surfaces

Hohmann, Judith K.; Freymann, Georg von

doi:10.1002/adfm.201401390

Cited by 34 publications

(27 citation statements)

References 39 publications

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“…[ 134 ] They fabricated structures built of 12 µm high posts, arranged on different grids and different post distances, with connecting thin rods in various ways ( Figure 9 a). Hohmann et al have shown that topographic parameters have a distinct infl uence on proliferation and morphology of osteoblast-like SaOs-2 cells.…”

Section: Interaction Of Cells With Scaffoldsmentioning

confidence: 99%

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Three‐Dimensional μ‐Printing: An Enabling Technology

Hohmann

Renner

Waller

et al. 2015

Advanced Optical Materials

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150

102

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functional elements, chiral photonic crystals, photonic metamaterials and quasicrystals. With this technology becoming commercially available, [ 1 ] many novel ideas have been realized by scientists around the world. Some of these developments can already be seen as new research areas enabled by 3D µ-printing.Many excellent reviews of the underlying technology have recently been published, and we give here just a short selection. [2][3][4][5] With the present progress report we want to summarize the tremendous technological development during the last fi ve years as well as to give an overview over some vastly growing research fi elds enabled by this development. As the number of research papers based on 3D µ-printing as enabling technology is exploding, we intend to categorize the most recent developments to identify future research directions and possible novel fi elds for the years to come. Recent Technological Advances in 3D µ-PrintingFrom the fi rst proof-of-principle in 1997, [ 6 ] the µ-printing community has continuously been expanding the structuring capabilities of µ-printing systems overcoming limitations such as structuring speed, sample volume, complicated pre and post processing, as well as minimum feature size and resolution. Progress is made along two directions: First, extending the aforementioned benchmarks of µ-printing systems. Second, techniques that move µ-printed structures towards functional devices. These two directions obviously are intertwined and require interdisciplinary research efforts on new photocurable materials, complex light-matter interaction, reaction kinetics as well as processes on a molecular level infl uencing structure formation. The most infl uential technological advances are summarized in this section.Section 2.1. covers recent work leading to a tremendous increase of the capabilities of µ-printing systems. Section 2.2. describes superresolution concepts exploiting light-matter interactions to achieve smaller feature sizes and higher structural resolution. Section 2.3. reviews spatial light modulator (SLM) based laser lithography providing additional degrees of freedom by shaping the wavefront of the laser beam. Laser Sources, Scanning Devices, and Writing GeometryThe high complexity of ultrafast fs-lasers drives the community to look for alternative laser sources, leading to cost and In this progress report the development of three-dimensional µ-printing and its impact as an enabling technology onto different scientifi c fi elds is reviewed. Driven by direct laser writing via two-photon absorption, the technology has reached a level of maturity and ease of application such that 3D printing on the micrometer scale can now be considered. While the underlying technology is still developing towards higher resolution and increasing speed of fabrication, the last fi ve years have seen new fi elds rising that were obviously enabled by 3D µ-printing. Among the recent technological developments discussed in this progress report are the fi elds of super-resolution lithography ...

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Section: Interaction Of Cells With Scaffoldsmentioning

confidence: 99%

Section: Interaction Of Cells With Scaffoldsmentioning

confidence: 99%

Three‐Dimensional μ‐Printing: An Enabling Technology

Hohmann

Renner

Waller

et al. 2015

Advanced Optical Materials

Self Cite

150

102

View full text Add to dashboard Cite

show abstract

“…Two‐photon polymerization based 3D printing technology is a newly developed direct laser writing (DLW) technology that can construct structures with sub‐micrometer resolution at a scan speed over 10 000 µm s −1 in three dimensions . During the past several years, similar technology has gained great interests from researchers due to the potential applications in biological engineering, physical study, and so on. In this work, we have successfully applied this 3D printing technology in fabricating pillar structures, singly, doubly, and triply re‐entrant structures (Figure S1, Supporting Information).…”

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confidence: 99%

3D Printing of Bioinspired Liquid Superrepellent Structures

et al. 2018

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Bioinspired re-entrant structures have been proved to be effective in achieving liquid superrepellence (including anti-penetration, anti-adhesion, and anti-spreading). However, except for a few reports relying on isotropic etching of silicon wafers, most fluorination-dependent surfaces are still unable to repel liquids with extreme low surface energy (i.e., γ < 15 mN m ), especially those fluorinated solvents. Herein, triply re-entrant structures, possessing superrepellence to water (with surface tension γ of 72.8 mN m ) and various organic liquids (γ = 12.0-27.1 mN m ), are fabricated via two-photon polymerization based 3D printing technology. Such structures can be constructed both on rigid and flexible substrates, and the liquid superrepellent properties can be kept even after oxygen plasma treatment. Based on the prepared triply re-entrant structures, micro open capillaries are constructed on them to realize directional liquid spreading, which may be applied in microfluidic platforms and lab-on-a-chip applications. The fabricated arrays can also find potential applications in electronic devices, gas sensors, microchemical/physical reactors, high-throughput biological sensors, and optical displays.

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“…The first studies on cells were performed on rather concise 3D scaffolds that consisted of a single material ( Figure A). Hohmann and von Freymann investigated the proliferation of osteoblast‐like cells on different 3D topographies and found that 3D culturing in square grids enhanced the proliferation up to 170% with respect to hexagonal structures or unstructured growth substrates . This indicates that the 3D adhesion geometry can influence cell cycle progression.…”

Section: Direct Laser Writing For Cell Culturementioning

confidence: 99%

3D Scaffolds to Study Basic Cell Biology

et al. 2019

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Mimicking the properties of the extracellular matrix is crucial for developing in vitro models of the physiological microenvironment of living cells. Among other techniques, 3D direct laser writing (DLW) has emerged as a promising technology for realizing tailored 3D scaffolds for cell biology studies. Here, results based on DLW addressing basic biological issues, e.g., cell‐force measurements and selective 3D cell spreading on functionalized structures are reviewed. Continuous future progress in DLW materials engineering and innovative approaches for scaffold fabrication will enable further applications of DLW in applied biomedical research and tissue engineering.

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Influence of Direct Laser Written 3D Topographies on Proliferation and Differentiation of Osteoblast‐Like Cells: Towards Improved Implant Surfaces

Abstract: topographies might on the long run guide the design of novel implants with decreased implant failure rates, if osteoblastic functionality is simultaneously secured by the structures.

Cited by 34 publications

References 39 publications

Three‐Dimensional μ‐Printing: An Enabling Technology

Three‐Dimensional μ‐Printing: An Enabling Technology

3D Printing of Bioinspired Liquid Superrepellent Structures

3D Scaffolds to Study Basic Cell Biology

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