Influence of diamino acid derivatives of protoporphyrin IX on mouse immunological system: Preliminary results

Kwitniewski, Mateusz; Kunikowska, Danuta; Dera-Tomaszewska, B.; Tokarska-Pietrzak, Ewa; Dziadziuszko, Halina; Graczyk, Alfreda; Głośnicka, R

doi:10.1016/j.jphotobiol.2005.07.003

Cited by 15 publications

(10 citation statements)

References 14 publications

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“…This is recognized as the gain of new function (GOF) of mutant p53. 19,20 The up-to-date reports indicate that the efficacy of PDT is attributed to its cellular, anti-vascular and immunogenic effects 2,21 The 1 st and 2 nd generation photosensitizers are the most common drugs applied in clinics. glioblastoma multiforme, breast cancer or ovarian cancer.…”

Section: P53 Tumor Suppressormentioning

confidence: 99%

p53 family members — important messengers in cell death signaling in photodynamic therapy of cancer?

Acedo

Zawacka-Pankau

2015

Photochem Photobiol Sci

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TP53 is one of the genes most frequently inactivated in cancers. Mutations in TP53 gene are linked to worse prognosis and shorter overall survival of cancer patients. TP53 encodes a critical tumor suppressor, which dictates cell fate decisions upon stress stimuli. As a sensor of cellular stress, p53 is a relevant messenger of cell death signaling in ROS-driven photodynamic therapy (PDT) of cancer. The significant role of p53 in response to PDT has been reported for several clinically approved photosensitizers. Multiple reports described that wild-type p53 contributes to cell killing upon photodynamic therapy with clinically approved photosensitizers but the mechanism is still not fully understood. This work outlines the diverse functions of p53 family members in cancer cells' susceptibility and resistance to PDT. In summary p53 and p53 family members are emerging as important mediators of cell death signaling in photodynamic therapy of cancer, however the mechanism of cell death provoked during PDT might differ depending on the tissue type and the photosensitizer applied.

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Section: P53 Tumor Suppressormentioning

confidence: 99%

p53 family members — important messengers in cell death signaling in photodynamic therapy of cancer?

Acedo

Zawacka-Pankau

2015

Photochem Photobiol Sci

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“…Porphyrin photosensitizers contain a heterocyclic ring, where various substituents, which define their properties, can be attached to it. Protoporphyrin and hematoporphyrin are very abundant thanks to the easiness of structure modification like the photosensitizers used in the work (Gomer, 1990;Pass, 1993;Graczyk & Konarski, 1995;Noodt et al, 1996;Ochsner, 1997;Żołądek et al, 1997;Sternberg & Dolphin, 1998;Graczyk, 1999;Li et al, 1999;Kessel & Luo, 1999;Graczyk & Kwaśny, 2002;Castano et al, 2005a;2005b;Kwitniewski et al, 2005;You et al, 2006;Misiewicz-Krzemińska et al, 2009). Usually, due to photosensitizers toxicity, their cytotoxicity in darkness must be examined.…”

Section: Discussionmentioning

confidence: 99%

“…The cell viability assay was used first to evaluate the cytotoxicity of PP(Arg) 2 and Hp(Arg) 2 towards LNCaP and next to find maximal non-toxic concentrations which were applied in PDT (Ryter & Tyrrell, 1999;Kwitniewski et al, 2009). It was shown that photosensitizers interact with LNCaP cells in darkness even without irradiation (Kwitniewski et al, 2005;Kwitniewski et al 2009). For each of investigated time and photosensitizers it was possible to determine a border, beyond which cell viability was going to decrease (Nowak-Stępniowska et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of PP(Arg)(2)- and Hp(Arg)(2)-mediated photodynamic therapy and early stage of apoptosis induction in prostate carcinoma in vitro.

Nowak-Stępniowska

Wiktorska²,

Małecki³

et al. 2011

Acta Biochim Pol

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Porphyrin photosensitizers tend to localize in mitochondria. The depolarization of mitochondrial membrane is one of the early stages of apoptosis and Laser Scanning Fluorescence Microscopy allows to determine changes in transmembrane mitochondrial potential under influence of PDT depending on the kind of photosensitizer (PP(Arg)(2), Hp(Arg)(2)), the energy dose (5, 10, 30 and 50 J/cm(2)) and time periods (24 and 48 hours after irradiation) in the LNCaP (lymphonodal metastasis of prostate carcinoma, the androgen dependent cell line). Cyototoxicity induced by PP(Arg)(2)- and Hp(Arg)(2)-based PDT depending on energy dose and time after irradiation in prostate carcinoma is determined with MTT. Generally, it was shown that lower energy doses induce greater changes in transmembrane mitochondrial potential. Hp(Arg)(2)-based PDT was more effective causing greater mitochondrial membrane depolarization and cell viability decrease in comparison to PP(Arg)(2)-mediated PDT (in the case of maximal nontoxic photosensitizer doses used).

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“…21−30 The enhancement of accumulation of porphyrin photosynthesizers against biological substrates can be achieved by conjugate formation with biomolecules (e.g., amino acids, proteins). 8,31,32 In the present paper, we describe the facile synthesis of lysine conjugated porphyrin and its coating on CdFe 2 O 4 nanoparticles. These nanoparticles were successfully synthesized by a self-assembly method of reflux reaction.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of tetrakis(carboxyphenyl)porphyrin coated paramagnetic iron oxide nanoparticles via amino acid for photodegradation of methylene blue

Rahimi¹,

Tadjarodi²,

Imani³

et al. 2013

Turk J Chem

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In this paper, synthesis of tetrakis(carboxyphenyl)porphyrin (TCPP) coated cadmium ferrite (CdFe 2 O 4) nanoparticles by using L-lysine as an anchor is reported for the first time. The ferrimagnetic CdFe 2 O 4 nanoparticles were prepared via the facile self-assembly method of reflux followed by a heating treatment. The obtained magnetic nanoparticles were coated with TCPP in the presence of the amino acid L-lysine by sonication in ethanol and then refluxing for 12 h. The structural characteristics of the products were determined using FT-IR and XRD pattern. Scanning electron microscopy (SEM) images indicated uniform morphologies of the magnetic nanoparticles with an average size of 43 nm. The magnetic properties of the prepared samples were characterized on a vibrant sample magnetometer (VSM) with maximum saturation magnetization values of 65.09 and 46.80 emu/g for nanoparticles and nanoparticle/TCPP. The synthesized products were successfully employed to remove the methylene blue (MB) dye from aqueous solutions by using visible light irradiation. The magnetic CdFe 2 O 4 nanoparticles indicated an enhancement of 13% for photodegradation of MB dye after being sensitized by TCPP.

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Influence of diamino acid derivatives of protoporphyrin IX on mouse immunological system: Preliminary results

Cited by 15 publications

References 14 publications

p53 family members — important messengers in cell death signaling in photodynamic therapy of cancer?

p53 family members — important messengers in cell death signaling in photodynamic therapy of cancer?

Cytotoxicity of PP(Arg)(2)- and Hp(Arg)(2)-mediated photodynamic therapy and early stage of apoptosis induction in prostate carcinoma in vitro.

Synthesis of tetrakis(carboxyphenyl)porphyrin coated paramagnetic iron oxide nanoparticles via amino acid for photodegradation of methylene blue

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