Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy

Saengkrit, Nattika; Saesoo, Somsak; Srinuanchai, Wanwisa; Phunpee, Sarunya; Ruktanonchai, Uracha

doi:10.1016/j.colsurfb.2013.10.005

Cited by 134 publications

(79 citation statements)

References 33 publications

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“…Human papilloma virus [107][108][109][110] It was reported that cationic liposomes could selectively accumulate in tumorous vascular endothelial cells so that cationic liposomes were made from antitumor carriers that would target tumorous vascular to reduce the toxicity of antitumor drugs. 111,112 CUR-loaded cationic liposomes were prepared by Saengkrit et al 113 using conventional thin-film hydration method and investigated the inhibitory activity against HPV18-and HPV16-positive cells. The results revealed that half maximal inhibitory concentration of Hela and SiHa cells was 21 μM and 16 μM, respectively.…”

Section: Cervical Cancermentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

301

208

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Section: Cervical Cancermentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

301

208

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“…The flow rate was set at 1 mL/min. For CUR, the amount of free and entrapped CUR was determined by dissolving the supernatant with a known amount of ethanol (1:10, v/v) (Saengkrit et al, 2014). The isocratic condition using mobile phase composed of 43% (w/w) acetonitrile and 57% of 1% (w/w) acetic acid in water.…”

Section: Preparation and Characterization Of Dtx-cur-lpnsmentioning

confidence: 99%

Targeted nanomedicine for prostate cancer therapy: docetaxel and curcumin co-encapsulated lipid–polymer hybrid nanoparticles for the enhanced anti-tumor activityin vitroandin vivo

Yan

Wang²,

Zhang

et al. 2015

Drug Delivery

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Chinese medicine is one nano-sized drug delivery system promising to generate synergistic anticancer effects, to maximize the treatment effect, and to overcome multi-drug resistance. The purpose of this study is to construct lipid-polymer hybrid nanoparticles (LPNs) as nanomedicine for co-encapsulation of DTX and curcumin (CUR). Methods: DTX and CUR co-encapsulated LPNs (DTX-CUR-LPNs) were constructed. DTX-CUR-LPNs were evaluated in terms of particles size, zeta potential, drug encapsulation, and drug delivery. The cytotoxicity of the LPNs was evaluated on PC-3 human prostate carcinoma cells (PC3 cells) by MTT assays. In vivo anti-tumor effects were observed on the PC3 tumor xenografts in mice.Results: The particle size of DTX-CUR-LPNs was 169.6 nm with a positive zeta potential of 35.7 mV. DTX-CUR-LPNs showed highest cytotoxicity and synergistic effect of two drugs in tumor cells in vitro. In mice-bearing PC-3 tumor xenografts, the DTX-CUR-LPNs inhibited tumor growth to a greater extent than other contrast groups, without inducing any obvious side effects. Conclusion: According to these results, the novel nanomedicine offers great promise for the dual drugs delivery to the prostate cancer cells, showing the potential of synergistic combination therapy for prostate cancer.

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“…Therefore, it is urgent to develop a suitable formulation to increase its solubility and systemic bioavailability. To our knowledge, a number of methods have been developed to improve the oral absorption of curcumin such as microemulsions (10), liposomes (11), nanoparticles (12), and so on.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System

Shi

et al. 2015

AAPS PharmSciTech

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Abstract. The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of CurDPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of CurDPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.

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Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy

Cited by 134 publications

References 33 publications

Liposomal curcumin and its application in cancer

Liposomal curcumin and its application in cancer

Targeted nanomedicine for prostate cancer therapy: docetaxel and curcumin co-encapsulated lipid–polymer hybrid nanoparticles for the enhanced anti-tumor activityin vitroandin vivo

Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System

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