Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System

Abstract

Abstract. The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of CurDPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of CurDPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

“…Recently, several researchers modified curcumin’s formulations for human applications (Hu et al 2015 [74], Ma et al 2013 [75] and several patent applications).…”

“…Hu and colleagues (2015) [74] suggested a dripping pill formulation with polyethoxylated 40 hydrogenated castor oil, poloxamer 188 and polyethalyne glycol 4000 may improve solubility and bioavailability of curcumin.…”

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

“…In a recent study, its uptake was improved significantly by piperine addition only in the case of oil-in-water emulsions stabilized by Poloxamer 407 (Gulseren et al, 2014).In addition, enhanced solubility and bioavailability of curcumin was reported by a new curcumin dripping pills (Cur-DPs) formulation (Hu et al, 2015).…”

Heat and pH stable curcumin-based hydrophilic colorants obtained by the solid dispersion technology assisted by spray-drying

“…Solid dispersions, produced with the main focus of improving curcumin bioavailability, were already obtained with encapsulants like Poloxamer 188 and polyethylene glycol (Hu et al, 2015), methacrylate copolymers and polyvinylpyrrolidone (PVP) (Meng et al, 2015), and cellulose-based polymers (Gangurde et al, 2015;Li et al, 2013). Particularly, in the case of curcumin solid dispersions based on PVP (Meng et al, 2015;Paradkar et al, 2004), an increased curcumin water affinity was observed (Seo et al, 2012).…”