2015
DOI: 10.1016/j.fct.2015.05.022
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The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

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Cited by 435 publications
(294 citation statements)
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References 171 publications
(129 reference statements)
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“…7,8 More importantly, no sign of toxicity was observed in animals or humans treated with CUR, indicating its in vivo safety. 9 However, its clinical application is still restricted by poor solubility in aqueous solution, poor oral bioavailability and extensive first-pass metabolism. 10 Nanotechnology has been widely used in the field of drug delivery and cancer therapy due to its advantages in developing aqueous-based formulations for hydrophobic drugs.…”
mentioning
confidence: 99%
“…7,8 More importantly, no sign of toxicity was observed in animals or humans treated with CUR, indicating its in vivo safety. 9 However, its clinical application is still restricted by poor solubility in aqueous solution, poor oral bioavailability and extensive first-pass metabolism. 10 Nanotechnology has been widely used in the field of drug delivery and cancer therapy due to its advantages in developing aqueous-based formulations for hydrophobic drugs.…”
mentioning
confidence: 99%
“…Research for more than two decades has revealed the pleiotropic nature of the biological effects of this molecule. More than 7000 published articles have shed light on the various aspects of curcumin, including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities (Ghosh et al, 2015). Apart from these wellknown actions, this natural compound also exerts its beneficial effects by modulating different signalling molecules including transcription factors, tumour suppressor genes, chemokines, cytokines, etc.…”
Section: Curcuminmentioning
confidence: 99%
“…To this end, in the present study, we assessed 12 pure natural compounds with the potential to modulate iron metabolism. All these compounds are extracts from traditional Chinese herbal medicinal plants, and many of them have been reported to be effective therapeutically for multiple disorders, including inflammation, oxidative injuries and cardiovascular diseases (12)(13)(14)(15)(16)(17)(18)(19)(20). According to the Chinese Pharmacopoeia (21), all of these compounds are capable of improving microcirculation and have the potential to modulate blood cell formation.…”
Section: Introductionmentioning
confidence: 99%