Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut

Abstract

Age, fasting period and blood glucose levels did not influence physiological uptake. However, there seemed to be a patient-specific pattern for stomach and bowel uptake.

Administration of unfractionated heparin with prolonged fasting could reduce physiological 18F-fluorodeoxyglucose uptake in the heart

“…The prevalence of this nonpathological glucose uptake is observed in up to 68% of patients who have no CDs (2).…”

Assessment of the myocardial FDG-PET image quality with the use of maximal Standardized Uptake Value myocardial to background index. Application of the results in regard to semiquantitative assessment of myocardial viability with cardiac dedicated softwar

“…Several authors have reported varying degrees of non-specific myocardial FDG uptake despite low blood sugar levels. De Groot et al [14] found that myocardial FDG uptake had no correlation with the fasting blood sugar level, fasting period, or age of the patient. In a similar study Kaneta et al found a negative correlation between the blood glucose level and FDG uptake, but the fasting period and age of the patient showed no relationship [15].…”

Radionuclide Techniques for Identifying Vulnerable Plaque

“…Elimination of the uptake typically seen in the myocardium requires either a pharmacologic or a dietary intervention (41,42). Although prolonged fasting has been suggested, there is no definite evidence that this intervention reliably suppresses myocardial uptake (43)(44)(45). Further clinical testing is required to develop a method that will eliminate myocardial uptake in all patients.…”