Radionuclide Techniques for Identifying Vulnerable Plaque

Dunphy, Mark; Schöder, Heiko; Strausś, H. William

doi:10.2967/jnumed.107.044651

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…The same group reported increased FDG uptake in the culprit vertebral artery of patients with symptomatic posterior territory stroke (6). Arterial inflammation imaging with FDG PET has now been extended from the carotid and vertebral arteries to the aorta (49,50) and iliac and femoral arteries (51,52). Anatomically, FDG uptake may be widespread, particularly affecting the carotid arteries (53) and proximal aorta (54).…”

Section: Fdg Pet Atherosclerosis Imaging: Clinical Studiesmentioning

confidence: 96%

Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography

Rudd

Narula

Strausś

et al. 2010

Journal of the American College of Cardiology

425

443

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Inflammation is a determinant of atherosclerotic plaque rupture, the event leading to most myocardial infarctions and strokes. Although conventional imaging techniques identify the site and severity of luminal stenosis, the inflammatory status of the plaque is not addressed. Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantification of arterial inflammation across multiple vessels. This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations.

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Section: Fdg Pet Atherosclerosis Imaging: Clinical Studiesmentioning

confidence: 96%

Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography

Rudd

Narula

Strausś

et al. 2010

Journal of the American College of Cardiology

425

443

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“…18 F-fluorodeoxyglucose (FDG) is a glucose analogue that can be non-invasively imaged using PET. Increased FDG uptake in the atherosclerotic artery wall has been shown in man [3][4][5][6][7][8][9][10][11] and animal imaging studies suggest that plaque macrophages account for most of the FDG uptake [12][13][14][15][16]. For drug efficacy tracking, reproducibility is excellent [17][18][19] and one study has suggested that FDG uptake could be used to monitor the effects of treatment on plaque macrophage content in vivo [14].…”

Section: Introductionmentioning

confidence: 99%

FDG–PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis

Davies

Izquierdo‐Garcia

Rudd

et al. 2009

Int J Cardiovasc Imaging

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The presence of activated macrophages is an important predictor of atherosclerotic plaque rupture. In this study, our aim was to determine the accuracy of (18)F- fluorodeoxyglucose (FDG) microPET imaging for quantifying aortic wall macrophage content in a rabbit model of atherosclerosis. Rabbits were divided into a control group and two groups post aortic balloon injury: 6 months high-cholesterol diet (HC); and 3 months HC followed by 3 months low-cholesterol diet plus statin (LCS). In vivo and ex vivo microPET, ex vivo well counting and histological quantification of the atherosclerotic aortas were performed for all groups. Macrophage density was greater in the HC group than the LCS group (5.1 +/- 1.4% vs. 0.6 +/- 0.7%, P < 0.001) with a trend towards greater macrophage density in LCS compared to controls (P = 0.08). There was a strong correlation across all groups between macrophage density and standardized uptake value (SUV) derived from ex vivo microPET (r = 0.95, P < 0.001) and well counting (r = 0.96, P < 0.001). Ex vivo FDG SUV was significantly different between the three groups (P < 0.001). However, the correlation between in vivo microPET FDG SUV and macrophage density was insignificant (r = 0.16, P = 0.57) with no statistical differences in FDG SUV seen between the three groups. This study confirms that in an animal model of inflamed and non-inflamed atherosclerosis, significant differences in FDG SUV allow differentiation of highly inflamed atherosclerotic aortas from those stabilized by statin therapy and low cholesterol diet and controls.

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“…Four broad categories of radiolabeled markers of atherosclerosis [3] exist; these markers include lipoproteins, antibodies, biomarkers of atherosclerotic inflammation, and markers of cell death. Table 1 presents these in more detail [4-18,19•,20].…”

Section: The Tracer Methodsmentioning

confidence: 99%

“…Intact human IgG [12] C. Cytokines [13] D. Glucose hypermetabolism (2-fluoro-2-deoxyglucose) [14][15][16] E. Matrix metalloproteinase [17] IV. Markers of cell death [18,19•,20] *Data from Dunphy et al [3]. LDL-low-density lipoprotein; oxLDL-oxidized low-density lipoprotein; SMC-smooth muscle cell.…”

Section: Lipoproteinsmentioning

confidence: 99%

Molecular imaging of atherosclerosis

Dunphy

Strausś²

2008

Curr Cardiol Rep

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Techniques are being developed for clinical molecular imaging of atherosclerosis to identify and characterize vulnerable plaques in each vascular territory. Molecular imaging encompasses multiple imaging modalities that depict cellular and subcellular processes. Molecular imaging can provide a "virtual histology" noninvasively about atherosclerotic disease, characterizing vascular lesions with markers of inflammation, angiogenesis, lipid metabolism, and more.

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Radionuclide Techniques for Identifying Vulnerable Plaque

Cited by 5 publications

References 33 publications

Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography

Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography

FDG–PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis

Molecular imaging of atherosclerosis

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