Administration of unfractionated heparin with prolonged fasting could reduce physiological 18F-fluorodeoxyglucose uptake in the heart

Abstract

Background: The physiological uptake of F-18 fluorodeoxyglucose (FDG) in the heart often

Joint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring

“…Furthermore, one study showed that despite undergoing an 18-h fast, 38% of individuals still demonstrated physiologic 18 F-FDG uptake, necessitating additional measures. 54 …”

Joint SNMMI–ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring

“…Although the reduction in physiologic uptake is significantly greater after more than 18 h of fasting than after a shorter fast, patient compliance with the longer fast can be challenging. Furthermore, one study showed that despite undergoing an 18-h fast, 38% of individuals still demonstrated physiologic 18 F-FDG uptake, necessitating additional measures (54).…”

Current Status and Future Direction of PET/MR in Cardiology

“…Kobayashi et al reported that carbohydrate restriction (<10 g of carbohydrate) for 24 hours or more with a low-carbohydrate, high-fat diet more effectively suppressed physiological FDG uptake compared with a fasting only protocol (15). Intravenous injection of unfractionated heparin combined with extended fasting is also reported to be effective in suppressing physiological FDG uptake (16,17). Unfractionated heparin increases serum free fatty acid, which suppresses myocardial glucose metabolism (18).…”