Influence of Aspirin on Healing of Chronic Gastric Ulcers in Dogs

Takeuchi, Ken; Okabe, S.; Takagi, Keijiro; Umeda, Noritsugu

doi:10.1159/000198055

Cited by 6 publications

(3 citation statements)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding parallels observations made in the case of aspirin (4). Aspirin does produce bleeding or mucosal erosions, but never ulcers which penetrate into the muscularis mucosa, at least in dogs (3,6,7).…”

Section: Discussionsupporting

confidence: 86%

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Okabe¹,

Tabata²

1981

Digestion

Self Cite

View full text Add to dashboard Cite

Effects of indomethacin on healed or partially healed gastric ulcers in the dog were studied. Gastric ulcers were produced by submucosal injection of 1 ml of 40% acetic acid solution into the bordering area of the fundus and antrum of the stomach. Indomethacin, 20 mg/kg, was given orally once daily for 5 days beginning on the 50th day after ulceration. While erosions or deep ulcers were produced by indomethacin, healed or partially healed acetic acid ulcers were not aggravated. Mechanisms involved in this strong resistance of healed ulcers to the ulcerogenic agent remain to be determined.

show abstract

Section: Discussionsupporting

confidence: 86%

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Okabe¹,

Tabata²

1981

Digestion

Self Cite

View full text Add to dashboard Cite

show abstract

“…With the experimental procedures for Type 1 and Type 2 ulcer models, ulcers were produced in mice, Mongolian gerbils (M. gerbils), 11) ferrets, guinea pigs, cats, [12][13][14] dogs (Figs. 7, 8), [15][16][17] and miniature pigs. 18) In dogs and pigs, gastric ulcers were easily produced by an endoscope equipped with an injection needle to inject 40% acetic acid (1 ml) into the desired stomach wall region.…”

Section: Type 2 Ulcer Modelmentioning

confidence: 99%

An Overview of Acetic Acid Ulcer Models<br>—The History and State of the Art of Peptic Ulcer Research—

Okabe

Amagase

2005

Biological & Pharmaceutical Bulletin

207

166

View full text Add to dashboard Cite

Four types of experimental chronic ulcer models, named acetic acid ulcer models, have been developed to examine the healing process of peptic ulcers, screen anti-ulcer drugs, and better evaluate the adverse effects of various anti-inflammatory drugs on the gastrointestinal mucosa. The model easily and reliably produces round, deep ulcers in the stomach and duodenum, allowing acetic acid ulcer production in mice, rats, Mongolian gerbils, guinea pigs, cats, dogs, miniature pigs, and monkeys. These ulcer models highly resemble human ulcers in terms of both pathological features and healing process. The models have been established over the past 35 years and are now used throughout the world by basic and clinical scientists. One of the characteristic features of acetic acid ulcers in rats is the spontaneous relapse of healed ulcers Ͼ100 d after ulceration, an endoscopically confirmed phenomenon. Indomethacin significantly delays the healing of acetic acid ulcers, probably by reducing endogenous prostaglandins and inhibiting angiogenesis in ulcerated tissue. Helicobacter pylori significantly delays healing of acetic acid ulcers and causes relapse of healed ulcers at a high incidence in Mongolian gerbils. Anti-secretory drugs (e.g. omeprazole), prostaglandin analogs, mucosal defense agents (e.g. sucralfate), and various growth factors all significantly enhance healing of acetic acid ulcers. Gene therapy with epidermal growth factor and vascular endothelial growth factor applied to the base of acetic acid ulcers in rats is effective in enhancing ulcer healing. Since an inhibitor of nitric oxide syntase prevents ulcer healing, nitric oxide might be involved in the mechanism underlying ulcer healing. We conclude that acetic acid ulcer models are quite useful for various studies related to peptic ulcers.

show abstract

“…7 ). Normally, gastric ulcers heal completely by the 7th week after ulceration [ 54 ], and therefore the application of AM has accelerated the re-epithelization of the gastric ulcer.…”

Section: Discussionmentioning

confidence: 99%

Novel approach to gastric mucosal defect repair using fresh amniotic membrane allograft in dogs (experimental study)

et al. 2017

View full text Add to dashboard Cite

BackgroundGastric mucosal defect could result from several causative factors including the use of nonsteroidal anti-inflammatory drugs, Helicobacter pylori infection, gastrointestinal and spinal cord diseases, and neoplasia. This study was performed to achieve a novel simple, inexpensive, and effective surgical technique for the repair of gastric mucosal defect.MethodsSix adult male mongrel dogs were divided into two groups (three dogs each). In the control positive group (C + ve), dogs were subjected to surgical induction of gastric mucosal defect and then treated using traditional medicinal treatment for such a condition. In the amniotic membrane (AM) group, dogs were subjected to the same operation and then fresh AM allograft was applied. Clinical, endoscopic, biochemical (serum protein and lipid and pepsin activity in gastric juice), histopathological, and immunohistochemistry evaluations were performed.ResultsRegarding endoscopic examination, there was no sign of inflammatory reaction around the grafted area in the AM group compared to the C + ve group. The leukocytic infiltration in the gastric ulcer was well detected in the control group and was less observed in the AM group. In the AM group, the concentrations of both protein and lipid profiles were nearly the same as those in serum samples taken preoperatively at zero time, which indicated that the AM grafting acted the same as gastric mucosa. The re-epithelization of the gastric ulcer in the C + ve group was not yet detected at 21 days, while in the AM group it was well observed covering most of the gastric ulcer. AM accelerated the re-epithelization of the gastric ulcer. The fibrous connective tissue and the precursor of collagen (COL IA1) were poorly detected in the gastric ulcer with AM application.ConclusionUsing fresh AM allograft for repairing gastric mucosal defect in dogs showed great impact as a novel method to achieve optimum reconstruction of the gastric mucosal architecture and restoration of pre-epithelial, epithelial, and post-epithelial normal gastric mucosal barriers.

show abstract

Influence of Aspirin on Healing of Chronic Gastric Ulcers in Dogs

Cited by 6 publications

References 4 publications

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

An Overview of Acetic Acid Ulcer Models<br>—The History and State of the Art of Peptic Ulcer Research—

Novel approach to gastric mucosal defect repair using fresh amniotic membrane allograft in dogs (experimental study)

Contact Info

Product

Resources

About

Influence of Aspirin on Healing of Chronic Gastric Ulcers in Dogs

Cited by 6 publications

References 4 publications

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

Does Indomethacin Activate Healed Gastric Ulcers in the Dog?

An Overview of Acetic Acid Ulcer Models<br>&mdash;The History and State of the Art of Peptic Ulcer Research&mdash;

Novel approach to gastric mucosal defect repair using fresh amniotic membrane allograft in dogs (experimental study)

Contact Info

Product

Resources

About

An Overview of Acetic Acid Ulcer Models<br>—The History and State of the Art of Peptic Ulcer Research—