Influence of antimicrobial photodynamic therapy in carious lesion. Randomized split-mouth clinical trial in primary molars

Alves, Luísa Valente Gotardo Lara; Curylofo-Zotti, Fabiana Almeida; Borsatto, Maria Cristina; Salvador, Sérgio Luiz de Souza; Valério, Rodrigo Alexandre; Souza‐Gabriel, Aline Evangelista; Corona, Silmara Aparecida Milori

doi:10.1016/j.pdpdt.2019.02.018

Cited by 38 publications

(28 citation statements)

References 46 publications

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“…In total, 21/38 of the articles (55.3%) showed a low risk of bias, with two articles [ 6 , 31 ] scoring 10/10, eleven [ 24 , 26 , 28 , 29 , 38 , 43 , 44 , 49 , 51 , 52 , 55 ] scoring 9/10, and eight [ 23 , 25 , 34 , 35 , 37 , 46 , 48 , 50 ] scoring 8/10.…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, for each dental research field, studies were allocated as: 8/17 in periodontitis [ 22 , 24 , 26 , 28 , 29 , 31 , 36 , 38 ]; 2/4 in peri-implantitis [ 39 , 41 ]; 4/5 in endodontics [ 43 , 44 , 46 , 47 ]; 5/5 in caries disinfection [ 48 , 49 , 50 , 51 , 52 ]; 0/2 in candida disinfection; 1/1 in halitosis [ 55 ]; 2/3 in OLP [ 56 , 58 ]; 0/1 in healing pericoronitis. …”

Section: Resultsmentioning

confidence: 99%

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Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

et al. 2020

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Background: Antimicrobial photodynamic therapy (aPDT) has been proposed as an effective alternative method for the adjunctive treatment of all classes of oral infections. The multifactorial nature of its mechanism of action correlates with various influencing factors, involving parameters concerning both the photosensitizer and the light delivery system. This study aims to critically evaluate the recorded parameters of aPDT applications that use lasers as the light source in randomized clinical trials in dentistry. Methods: PubMed and Cochrane search engines were used to identify human clinical trials of aPDT therapy in dentistry. After applying specific keywords, additional filters, inclusion and exclusion criteria, the initial number of 7744 articles was reduced to 38. Results: Almost one-half of the articles presented incomplete parameters, whilst the others had different protocols, even with the same photosensitizer and for the same field of application. Conclusions: No safe recommendation for aPDT protocols can be extrapolated for clinical use. Further research investigations should be performed with clear protocols, so that standardization for their potential dental applications can be achieved.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

et al. 2020

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“…The systematic review showed that among the cariogenic microorganisms listed in the selected studies, the most studied microorganism was Streptococcus mutans (82%) [12,14,15,16,17,18,19,20,21,23,24,25,26,27,28,29,31,32,33,34,35,37,39,40,41,42,43,45].…”

Section: Resultsmentioning

confidence: 99%

“…The success of PDT depends on factors such as the administrated dose of light in the target cells and the time of exposure to light [46]. Considering these factors, we found that the most widely used light source was the red LED (32%) with wavelengths ranging from 625 to 670 nm [12,15,16,17,18,21,24,29,30,32,36,40], the most commonly used PS was methylene blue [13,16,18,21,23,24,27,28,29,30,32,33,36,38,39,42], and the most widely used pre-irradiation time was 5 min [12,14,15,16,17,19,20,21,22,27,28,30,31,32,33,39,42,43,45].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Oliveira

Ferrisse

Marques

et al. 2019

IJMS

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The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.

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The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

Aghili,

Jahangirnia,

Alam

et al. 2023

J Basic Microbiol

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Several resistance mechanisms are involved in dental caries, including oral biofilms. An accumulation of bacteria on the surface of teeth is called plaque. Periodontitis and gingivitis are caused by dental plaque. In this review article, we aimed to review the studies associated with the application of photodynamic therapy (PDT) to prevent and treat various microbial biofilm‐caused oral diseases in recent decades. There are several studies published in PubMed that have described antimicrobial photodynamic therapy (APDT) effects on microorganisms. Several in vitro and in vivo studies have demonstrated the potential of APDT for treating endodontic, periodontal, and mucosal infections caused by bacteria as biofilms. Reactive oxygen species (ROS) are activated in the presence of oxygen by integrating a nontoxic photosensitizer (PS) with appropriate wavelength visible light. By causing irreversible damage to microorganisms, ROS induces some biological and photochemical events. Testing several wavelengths has been conducted to identify potential PS for APDT. A standard protocol is not yet available, and the current review summarizes findings from dental studies on APDT.

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Influence of antimicrobial photodynamic therapy in carious lesion. Randomized split-mouth clinical trial in primary molars

Cited by 38 publications

References 46 publications

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

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