Influence of an Increased Intraluminal Pressure on Intestinal Absorption

Anderson, Raymond E.; Schmidtke, Wendell; Diffenbaugh, Willis G.

doi:10.1097/00000658-196208000-00014

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…The movements must be regarded as homogenizing the contents and increasing both the pressure oftheir contact with the mucosal surface and the area over which this takes place; in this respect, they appear to be chiefly concerned with the absorption of water and salts (Anderson, Schmidtke, and Diffenbaugh, 1962). As Schwarz FIG.…”

Section: Discussionmentioning

confidence: 99%

Colonic motor activity and bowel function. I. Normal movement of contents.

Ritchie¹

1968

Gut

106

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Section: Discussionmentioning

confidence: 99%

Colonic motor activity and bowel function. I. Normal movement of contents.

Ritchie¹

1968

Gut

106

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“…Segmentation has been recorded from the colonic lumen by indwelling sensors as pressure waves representing non‐propulsive, non‐peristaltic contractions of colonic smooth muscle . This segmental activity mixes and homogenizes the content while increasing its exposure to the mucosal surface in order to facilitate the absorption of water and salts …”

Section: Electrical and Mechanical Features Of Each Predicted Motor Pmentioning

confidence: 99%

“…3 This segmental activity mixes and homogenizes the content while increasing its exposure to the mucosal surface in order to facilitate the absorption of water and salts. [4][5][6] In a recent paper published in Nature Communications, Huizinga et al 7 provide evidence for a coordinated role of two networks of interstitial cells of Cajal (ICC) in the segmentation motor activity of the small intestine. Rhythmic contractions were recorded together with constant amplitude slow waves of the same frequency.…”

mentioning

confidence: 99%

Interplay between myogenic pacemakers and enteric neurons determine distinct motor patterns in the rat colon

Mañé

Jiménez

2014

Neurogastroenterology Motil

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Waxing and waning of slow waves amplitude has been recently associated with a segmentation motor pattern in the murine small intestine. The 'wax and wane' phenomenon in this area of the gastrointestinal tract seems to be the result of modulation of slow waves by a second pacemaker of a lower frequency displayed by the interstitial cells of Cajal near the deep muscular plexus (ICC-DMP). In the rat colon, smooth muscle cyclic depolarizations causing low-frequency (LF) contractions (0.9 ± 0.1 cpm) occur together with slow wave activity associated to high-frequency (HF) contractions (14 ± 0.3 cpm; ripples). In the present manuscript, we demonstrate the presence of 'wax and wane' in rat colonic slow waves. Depolarization from the 'wax' to the 'wane' was 7.6 ± 1.2 mV, i.e., smooth muscle cells went from a resting membrane potential (RMP) of -50.0 mV to a RMP of -42.4 mV. The amplitude of the slow wave decreased from 14.0 ± 2.2 mV to 3.4 ± 0.7 mV. The wax and wane phenomenon occurred at 0.9 ± 0.1 cpm, coinciding with the frequency of cyclic depolarizations. Therefore, we hypothesized that the 'wax and wane' of slow waves in the rat colon could be the result of their interaction with the LF pacemaker. We describe three different myogenic motor patterns that depend on the level of smooth muscle and ICC excitation: (i) LF propulsive contractions, (ii) regular slow waves causing ripples, and (iii) a wax and wane pattern that may lead to segmentation. Different intra- and extra-luminal inputs probably determine the dominating motor pattern in each area through the enteric nervous system.

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